Lifeboat Foundation

Given there is to be a Reddit AMA on December 7th with Dr. Aubrey de Grey in the futurology subreddit, we thought it was a great time to have a look at the progress the SENS Research Foundation has made in tackling the aging processes. What follows is a brief summary of some of the highlights of their research efforts as well as the details of the AMA where you can ask Aubrey anything you like about his work.

Given that there is to be a Reddit AMA on December 7th with Dr. Aubrey de Grey in the Futurology subreddit, we think it’s a great time to have a look at the progress that the SENS Research Foundation has made in tackling the aging processes. What follows is a brief summary of some of the highlights of their research efforts as well as the details of the AMA, in which you can ask Aubrey anything you like about his work.

Today, there are many drugs and therapies that we take for granted. However, we should not forget that what is common and easily accessible today didn’t just magically appear out of thin air; rather, at some point, it used to be an unclear subject of study on which “more research was needed”, and even earlier, it was just a conjecture in some researcher’s head.

Continue reading “SENS: Progress in the Fight Against Age-related Diseases” »

Dr. Hébert will be in Berlin to provide an update on his fascinating work. The use of stem cells to repair the brain is relatively straightforward for Parkinson’s disease, in which cell depletion is localized to one small region, but in Alzheimer’s disease and other conditions, the cell loss is widely distributed, whereas cells can only be injected into one spot. The solution that Dr. Hébert explores is to make those cells migrate before dividing and differentiating.

https://www.undoing-aging.org/dr-jean-hebert-to-speak-at-undoing-aging-2018

Dr. Aubrey de Grey is the Chief Science Officer, founder of the SENS Research Foundation (SRF) and one of the original proponents of a damage repair-based approach to aging and age-related diseases. His work has inspired many others to think about aging differently and entertain the idea that, perhaps, we do not have to accept the suffering that age-related diseases cause.

Recently, Dr. de Grey published an article in MIT Technology Review; here, we explain why this is a real milestone of progress.

Aubrey de Grey has set himself a simple task. The 54-year-old cofounder of the SENS Research Foundation wants to end biological aging for good. So sure is he of his mission, he proclaims the first human being to live to the age of 1,000 has already been born. De Grey believes that, within the next 20 years or so, scientists will finally solve one of humanity’s greatest problems.

“The fact is, aging kills 110,000 people worldwide every fucking day,” de Grey said at a Virtual Futures event attended by Inverse in London on Wednesday, in a conversation with group director Luke Robert Mason. “It doesn’t just kill them. You have to take into account all the suffering that comes before.”

Through his foundation, de Grey is working to solve seven types of aging damage that he believes are the key to a breakthrough. These are tissue atrophy, cancerous cells, mitochondrial mutations, death -resistant cells, extracellular matrix stiffening, extracellular aggregates, and intracellular aggregates. It may sound like a complex salad of jargon, but de Grey claims that because science has an understanding of how to fix all these damages, aging can end for good.

Continue reading “Why This Aging Expert Thinks First 1,000-Year-Old Person is Already Alive” »

I think the talk was well received, and I appreciate them hearing me out.

Summary: Microbiome study of centenarians shows that ‘ridiculously healthy’ elderly have the same gut bacteria composition as healthy 30 year-olds. Can a more robust microbiome lead to the longer healthier life enjoyed by centenarians, or is it the other way around? [This article first appeared on LongevityFacts, follow us on Google+ | Facebook | Reddit. Author: Brady Hartman. This article was updated Dec. 2, 2017]

A recent study found that centenarians have the same microbiome as 30-year-olds.

In one of the most extensive studies of the human microbiome to date, an international group of researchers linked a healthy gut with “ridiculously healthy” elderly known as centenarians. This important study was conducted by the China-Canada Institute (CCI), a collaboration of geroscientists from the Lawson Health Research Institute, Western University, and Tianyi Health Science Institute in China. The researchers published their study titled “The Gut Microbiota of Healthy Aged Chinese Is Similar to That of the Healthy Young,” in the journal mSphere.

Continue reading “Researchers Link Human Microbiome With ‘Ridiculously Healthy’ Aging in Centenarians” »

Summary: The goals of geroscience are to help us live longer and healthier. A new film clip from Kurzgesagt explains the rationale behind lifespan-extension science, and why it’s not just about living longer but also living healthier.

(Video) Why Age? Should We End Aging Forever?

Continue reading “(Video) Why Age? Should We End Aging Forever?” »

Summary: Novel resveratrol analogs rejuvenate aging human cells, lengthening their Full Explanation of Telomeres.

Telomeres are a unique segment of DNA that sits at the end of the chromosome. Telomeres have repetitive sequences that are recognized as the end of the chromosome but are only there to keep the chromosome from becoming frazzled or damaged. Moreover, every time the cell divides, the telomeres also divide. But sometimes the telomeres can become shorter. As they grow shorter, they act like a clock that lets the cell know how old it is. The length of the telomere is the molecular clock, predicted by Hayflick. The telomere mechanism limits the number of times a cell can divide without losing DNA. When telomeres become too short, the cells cease multiplying and either become senescent or die.

Moreover, one of the interesting features about telomeres is that in cancer cells stay immortal by keeping their telomeres long. That means that cancer cells can continue dividing, long after they should have reached the end of their lifespan. This is one of the tactics that cancer cells use to trick the body into letting them keep replicating. [Source – NHGRI and Wikipedia.].

Continue reading “Old Human Cells Rejuvenated with ‘Breakthrough’ Anti-Aging Discovery” »

When taken daily, rapamycin causes side effects, the most serious of which include an increased risk of infection due to immune suppression, elevated blood sugar, and an increased risk of type 2 diabetes. Some of the side effects of daily rapamycin therapy are extremely serious, occasionally causing death due to infections. The complete list of side effects reported by daily rapamycin users includes high cholesterol, high triglycerides, glucose intolerance, insulin resistance, new-onset diabetes, anemia, thrombocytopenia, gastrointestinal disorders, sinusitis, respiratory and urinary infections, testicular dysfunction, and skin problems.

Daily vs. Intermittent Rapamycin Therapy

Rapamycin therapy is promising. However, researchers still need to determine the dosage that provides health benefits while eliminating harmful side effects. Scientists think they have already found the answer because rapamycin behaves differently when taken daily, as opposed to intermittently.

Continue reading “Can a Revolutionary Rapamycin Therapy Slow Down Aging in Our Bodies?” »