Lifeboat Foundation

Interesting results in mice but don’t jump on the bandwagon yet.

Fisetin is a naturally occurring plant polyphenol from the flavonoid group, similar to quercetin. It is present in many plants, where it acts as a colouring agent. It is also found in many fruits and vegetables, such as strawberries, apples, persimmons, onions, and cucumbers.

It has also been found to be a senolytic compound able to clear senescent cells, at least it does in vitro studies in a petri dish[1]. The clearance of dysfunctional senescent cells is one of the repair based approaches proposed by the SENS Research Foundation to prevent or reverse age-related diseases.

Continue reading “Fisetin a Compound in Strawberries Slows Aging in Mice” »

Reason at Fight Aging! discusses the need to fund and support advocacy as much as research. Ultimately profressional advocacy and marketing could help popularize the field. Currently advocacy is left to a handful of volunteers and zealous individuals and that is not an optimal strategy for growth.

Useful activities in our community can be powered either by zealotry or by money. Zealotry has the advantage of being cheap, but the profound disadvantages of being rare, unreliable, and never quite optimally opinionated for the task at hand. Set a zealot to a challenge and you get the output the zealot decides upon, and only for so long as he or she is suitably motivated by whatever internal alchemy is at work in that particular case. Sustainable, reliable, long-term zealots only exist in stories. Money, on the other hand, has the disadvantage of being expensive, but for for so long as income is greater than expenditure, it can be used to produce reliable, sustainable, long-term outcomes. Changing the world always starts with the zealots, but the whole point of the subsequent bootstrapping process is to transition to money rather than zealotry as a power source just about as rapidly as possible. The future is defined by the few visionaries who care greatly enough to set aside their lives to work upon it, but it is enacted by the vastly greater number of people who take a paycheck and go home at the end of the work day.

To the extent we agree that the advocacy, fundraising, and other matters accomplished via Fight Aging! are good things, we’d like to see more of this taking place. More of it, and not dependent on the fickle motivations of zealots. Ultimately that means finding ways to do what Fight Aging! does, but for profit, with money. In this I do not mean Fight Aging! itself, which will be powered by zealotry until such time as the alchemy fails, at which point it will vanish just like everything else does in time, but something like it, and preferably dozens of varied somethings. Experimentation and diversity drive progress, and we won’t find out exactly what it is that Fight Aging! is doing suboptimally without the existence of many other attempts at the same types of initiative.

In the years that I have been running Fight Aging!, I’ve seen many longevity science interest and news sites come and go. Zealotry has a short half-life. When it comes to the money side of the house, things haven’t been much better, however. The typical ad-supported sites roll over and die fairly quickly; there never was enough money in that to do it for a niche interest such as ours over the past fifteen years. Their business models fail, and they linger a little while on the fumes of zealotry until that also departs. The initiatives that try sponsorship from the “anti-aging” marketplace tend to last longer, but are so corrupted by that revenue that they quickly lose all possible usefulness and relevance. You can’t take money from people pushing interventions that do not work and still speak with correctness and authority.

Continue reading “Envisaging For-Profit Alternatives to Fight Aging! and Similar Initiatives” »

Previously he said 10 years and that was 2016 where he said 2 years until phase 1 human trials.

Is it an impossible dream to find Ponce de Leon’s Fountain of Youth? No! I’ve just attended my 67th reunion at The Harvard Medical School (HMS) and, while interviewing Dr. George Church, I discovered it is no longer science fiction.

Dr. Church, Professor of Genetics at HMS, one of the world’s great scientists, predicts we are about to end the aging process. In the next five years no less! That’s why I say — damn it! I was born too soon.

Continue reading “Does the Fountain of Youth really exist?” »

A new aging biomarker system has been published and it looks pretty robust.

Chronological age is now generally accepted by academics as being a poor means to identify how a person is aging. Far more useful is a person’s biological age in evaluating how fast someone is aging.

Biological age is assessed using indicators known as aging biomarkers, and as rejuvenation biotechnology draws ever nearer, there is an urgent need for more effective biomarkers. As well as finding effective biomarkers, another challenge in the field of aging research is seeking consensus among academics as to which biomarkers are the best ones to use.

Continue reading “Cell Functional Age Shows How Old You Really Are” »

The benefits of rejuvenation biotechnologies would extend to the whole human society. #aging

Rejuvenation isn’t good just for individuals and the people close to them. It is good for society as a whole, for a number of reasons. These reasons—which I will now proceed to discuss—should be enough make rejuvenation research a top priority for humanity in its entirety.

Ever heard anyone lamenting that the great minds of history are no longer with us? That we could certainly do with all the Einsteins, Montalcinis, Fermis, Curies, etc, living longer? And have you ever felt saddened when a great mind of our time died? You probably did, or at the very least know someone who did.

Just imagine how much faster would science and progress march if our greatest physicists, doctors, engineers, philantrophists, etc, could live an indefinitely long life. Remember that we’re not talking about a longer life spent in decrepitude and sickness: We’re talking about a 200-year-old Einstein with the experience of two centuries but the physical and mental agility of a 25-year-old. If he was still alive, maybe he could’ve figured out how to unify general relativity with quantum mechanics—something that has been eluding all efforts for decades. Every time a great person (or any person, for that matter) dies, their particular experience is lost forever. Never mind that there are other experts, or that similar knowledge is found in books; it’s not even remotely the same. Rejuvenation would allow us to benefit from the knowledge and wisdom of the best among us for centuries on end.

Continue reading “Rejuvenation is good for society” »

Increasing the level of autophagy might be the key to effective treatment of heart disease.

Today we will be looking at a new study that is attempting to treat atherosclerosis, one of the biggest age-related killers globally. As we age, our risk of developing atherosclerosis rises along with related conditions, such as hypertension.

We will be taking a look at new research that has reversed atherosclerosis in mice and is on the road to clinical trials in the future. Before we do that, let’s talk a little bit about how the disease develops and how macrophages work.

Continue reading “Using Macrophages to Reverse Atherosclerosis” »

Scientists have been examining Greenland sharks — some of which were born in the 1750s.

By John von Radowitz

(Al Bello/Getty Images)

Jeanne Calment, the French woman who holds the record for the longest verified lifespan, died in 1997 at 122 years old.

Few people, of course, ever become supercentenarians — 110 years old or older — and even fewer hit 115.

Continue reading “Scientists are questioning the idea that the human lifespan has a limit” »

An article discussing the benefits of rejuvenation for your friends and family.

Rejuvenation biotechnologies would bring significant benefits to individuals, but these benefits would indirectly extend to their families and friends too. The ways they can benefit from the rejuvenation of others might be not so obvious, so let’s have a look at them together.

Nearly everyone knows how terrible it is to lose people dear to you. Maybe your grandparents died when you were a child, and that might have been your first encounter with death, at an age when you still couldn’t properly comprehend it. Maybe it happened suddenly, or maybe your grandparents have suffered for long before passing away. Eventually, the moment comes when you start thinking that the same fate awaits your parents, your siblings, your friends. Rejuvenation would spare you seeing your elderly relatives and friends wilt away, suffer and die, because none of that would happen to them. Of course, rejuvenation would spare this pain to your friends and relatives too. Your children and grandchildren would never have to see you become sicker and sicker as you age, and would never—in principle—have to bury you. Today, being 80 means you often have to attend the funeral of a dear friend who passed away. People who have been important parts of your life just keep dying.