Lifeboat Foundation

Autophagy means “eating of self” (“auto”= self; “phag” = eating)[1]. Although its name might sound harmful, autophagy appears to have longevity-promoting effects[2]. Here, we will explain what autophagy is, how it works, its benefits, and how it plays a role in aging.

What is Autophagy?

Autophagy is the way cells break down misbehaving or nonfunctional organelles and proteins in the cell[1,2]. This means autophagy can consume organelles such as, mitochondria, peroxisomes, and the endoplasmic reticulum[1].

Antoxerene performs pipeline testing for small molecule drugs that target protein-drug and protein-protein interactions. The platform is based on a patent-pending production technology, which enables manufacturing of impossible to express protein targets in biologically active form, at scale.

The Italian version of Rejuvenaction is up and running! If you know Italian speakers who would like to know about rejuvenation biotechnologies and advocacy, please let them know!

I’m pleased to announce the launch of Rejuvenaction Italia, the Italian version of Rejuvenaction. As you might know, Italian is my native language, and while I have neglected/postponed online advocacy in Italian for over two years now, I realised that, as the topic of rejuvenation starts to reach broader audiences, there’s a necessity to make information available in several languages, for the benefit of those who don’t speak English. Regardless of one’s native language, the questions people have about rejuvenation are always the same: How do you do it? Why? Have you thought of overpopulation? And tyrants living forever? and so on. Thus, Rejuvenaction Italia (henceforth officially nicknamed RJi, and accordingly Rejuvenaction will be simply RJ) is essentially a clone of RJ, except in Italian. The blog won’t be nearly as lively as that here on RJ because, you know, there are only 24 hours in a day. I will translate some of the most substantial posts or important news from RJ to RJi, though, and there will be RJi -specific posts that won’t be worth translating into English.

If you speak Italian and/or know someone who does, it may be worth checking out RJ’s Italian clone and share the news on your social media. I would appreciate that very much. 🙂 There’s a link to RJi at the top of the sidebar.

Continue reading “Introducing Rejuvenaction Italia and other news” »

DUBLIN, August 21, 2017 /PRNewswire/.

The “Regenerative Medicine Market, 2014 — 2025” report has been added to Research and Markets’ offering.

The global regenerative medicine market size is expected to reach USD 5.59 billion by 2025, according to this new report. Increased prevalence of neurodegenerative, orthopedic, and other aging-related disorders in geriatric population coupled with rising global geriatric population is anticipated to drive market growth.

The original date of this broadcast was on August 20, 2017. Zoltan Istvan is the creator of the Transhumanist political party.
Subjects discussed: Cryonics, The merging of machines and humans, advance technology, transhumanism, CRISPR and Artificial Intelligence.

Listen to Flow of Wisdom Radio Live Sundays 3 — 5:00 PM EST on a radio station near you! Also, streaming live on GCNLive.com Call in 877−300−7645. http://flowofwisdom.com

Continue reading “FLOW OF WISDOM Interview w/ Zoltan Istvan founder of the Transhumanist Party HR1” »

Mimetic Evolution or the collective will of humanity to imitate the most successful achievements of nature with technology, has finally set in. At this dawn of artificial intelligence humanity is trying to not only find its place again, but to do the inevitable, the inescapable – merging with the technology we created. We have to be the artificial intelligence by incorporating the transcendent aspects of an artificiality that otherwise could easily become a mastermind, both in control of us and out of control.

Yes, it will begin slowly with AI helping us to achieve dreams of humanity, ways for us to live longer and healthier. Just ask what the many biotech companies focus on and the answer unanimously will be putting an end to aging.

The idea of eternal youth and immortality is a blessing, albeit a mixed one. We learned that progress never stops and it isn’t plausible to think that we now revert back and suddenly stop working on machine learning and connected devices as well as connected thinking.

Continue reading “With Immortality On The Horizon, Will Humanity Be Able To Survive The Technological Transition?” »

As your body ages, increasing amounts of your cells enter a state of cellular senescence. These cells no longer divide or support the tissues of which they are a part, and they emit a cocktail of harmful chemical signals that encourage other nearby cells to also enter the same senescent state.

The presence of senescent cells contributes to decreasing tissue function, increases chronic inflammation, and can even raise the risk of cancer and other age-related diseases.

Senescent cells normally destroy themselves via a programmed process called apoptosis and are removed by the immune system; however, the immune system declines with age, and increasing numbers of these senescent cells escape this disposal process and accumulate.

Set on Sir Richard Branson’s Necker Island, the third annual Blockchain Summit, hosted by BitFury, a leading full service Blockchain company, and Bill Tai, a venture investor and technologist, has come to a close. This event was an intimate, if perfectly balanced, gathering of technology, policy, investment and business leaders from around the world and across sectors. Topics ranged from the public policy implications of what is being heralded as a foundational technology, to new emerging business models that can ride on the very rails that enabled the global bonanza of digital currencies like Bitcoin. A key question that underpinned the Summit is if Blockchain could not have existed without the Internet, what could not exist without Blockchain?

Blockchain technology can undoubtedly change industries, especially those that labor under often byzantine, opaque and friction-laden business models. While many of the early pioneers are focusing on finance and insurance, the opportunities for this radical technology may very well reorder society as we know it. The remarkable case of Estonia, for example, shows a country reinventing itself into a future-proof digital state, where citizen services are rendered nearly instantaneously and to people all over the world. Similarly, promising work inspired by the famed Peruvian economist, Hernando de Soto, on improving land registries is being carried out by BitFury in a host of countries. With land and property being the two largest assets people will own — and the principal vehicle of value creation and wealth transfer — an unalterable, secure and transparent registration process should give the world comfort and elected leaders longevity.

What drives this unique technology is the power of distributed singularity, from which Blockchain’s identity pioneers like Dr. Mariana Dahan, who launched the World Identity Network on Necker Island, and Vinny Lingham of Civic, draw their inspiration. Blockchain operates on the basis of a distributed ledger (or database) system, inexorably marching forward recording and time-stamping transactions or records. While some may herald Bitcoin as Blockchain’s “killer app,” it is easy to maintain that the killer app is not the digital currencies that ride on Blockchain’s rails, but rather the rail system altogether. Two trains can ride on rails. But a high-speed maglev train is a decidedly faster mode of transport than a steam engine. Just as the maglev makes little or no contact with the rails enabling low-friction transport, the Blockchain can greatly reduce the friction in how the world transfers and records value.

Continue reading “Blockchain and the Power of Singularity” »

She goes on to detail which expressions and messages can increase public acceptance and which have proven to be counterproductive. Related cognitive biases are also briefly discussed.

Elena is a LEAF/Lifespan.io Director of the Board and the head of its Outreach/Fundraising committee, and has been a longevity activist and advocate since 2013. Since then she has organized educational events to make new evidence-based methods of healthy life extension more popular, and is member of the Russian transhumanist movement.