Retro Biosciences, a startup with $180 million from Sam Altman, has a simple and audacious goal: Add 10 good years to your life. And until now, we haven’t had a glimpse of its best ideas.
The research builds on a recent body of work that suggests that #mitochondria are social organelles that can talk to one another even when they are in different tissues.
Biologists discovered that mitochondria in different tissues talk to each other to repair injured cells. When their signal fails, the biological clock starts winding down.
Summary: Scientists are using epigenetic clocks to reveal our biological age, a true marker of health.
A new study delves into the immune system’s role in understanding and improving the accuracy of these clocks. Their innovative approach sheds light on the relationship between immune cell composition and biological age, with a focus on the balance between naïve and memory immune cells.
This research has significant implications for aging insights, health interventions, and targeted cancer treatments.
German researchers are developing an algorithm to help decode ancient cuneiform tablets — including those containing the oldest known work of world literature.
Ancient poem: The Epic of Gilgamesh is a Babylonian poem first written in cuneiform characters on clay tablets around 4,000 years ago. It tells the story of Gilgamesh, the king of the city of Uruk, and his quest for immortality.
Continue reading “AI is helping decode the oldest story in the world” »
Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhDDiscount Links: Green Tea: https://www.ochaandco.com/?ref=conqueragingTelomere, Epigenetic Te…
In this episode, Peter and Elon hop on X Spaces to discuss Data-driven optimism, solving grand challenges, uplifting humanity, Digital Super Intelligence, Longevity, Education, and Abundance in 2024.
Elon Musk is a businessman, founder, investor, and CEO. He co-founded PayPal, Neuralink and OpenAI; founded SpaceX, and is the CEO of Tesla and the Chairman of X.
Continue reading “Elon Musk Discusses Abundance, AGI, and Media in 2024 with Peter Diamandis” »
During our lives, normal exposures cause DNA damage to build up. Eventually, this causes cancer and age-related diseases. Studying DNA-repairing animals could help treat these issues.
Several techniques currently are used to determine the pace of aging in animals and, to a lesser degree, in humans. However, the techniques used in humans lack accuracy, don’t assess aging in specific organs, are not widely available, and are expensive.
A multi-institutional research team measured the levels of nearly 5,000 human proteins in 5,676 people of all ages who were followed for as long as 15 years in five prospective longitudinal cohorts. Each measured protein was associated with specific organs, based on previous studies: adipose tissue, artery, brain, heart, immune tissue, intestine, kidney, liver, lung, muscle, or pancreas. Combinations of proteins indicated the pace of aging in each organ. Accelerated aging of one organ was found in nearly 20% of people, and accelerated aging of multiple organs was noted in ≈2%. Accelerated aging in a specific organ correlated with risk for developing disease in that organ. For example, people with accelerated heart aging (vs. those without it) had 250% higher risk for developing heart failure, and people with accelerated brain and vascular aging had nearly 60% higher risk for developing Alzheimer disease.
Various tools — from sequencing a person’s genome to measuring gene expression (e.g., the “methylome”) — are becoming available to predict a person’s risk for developing particular diseases. Will these predictions lead to interventions that lower risk? The jury is still out on that question.
😀 They say we could even regenerate human limbs this way aswell as repair human blood vessels.
Cell tubes, made entirely from a patient’s own cells, are just as elastic as blood vessels but much stronger. Skin cells cultured into lumps are skewered on needles on a base, similar to a Kenzan, a tool used in Japanese flower arrangements, and formed into a tube. The technique, called the Kenzan Method, was made possible by a 3D bioprinter. A clinical trial is underway in Japan to transplant these tubes into humans in place of blood vessels. Studies are being done to apply them to nerves and organs.
Taking out the trash: Autophagy genes help extrude protein aggregates from neurons in the nematode C elegans.
