Researchers have discovered two spikes in our ageing. Here’s how to turn back the clock.
Category: life extension – Page 41
Scientists discover 500-year-old shark, Earth’s longest living vertebrate
This is superlongevity! ♾️
“One shark, measuring five meters, was found to be at least 272 years old, with an upper age estimate of more than 500 years (392 +/- 120 years). Another specimen was at least 260 years old, potentially exceeding 400 years. “We definitely expected the sharks to be old, but we didn’t expect that it would be the longest-living vertebrate animal,” Nielsen said.”
The Greenland shark holds the title as the longest-lived vertebrate on Earth, with some individuals potentially reaching 500 years of age. This elusive deep-sea predator, found in the frigid waters of the North Atlantic and Arctic Oceans, has fascinated scientists due to its remarkable lifespan. Its slow growth rate and mysterious biology have made it a subject of ongoing research, shedding light on how some species defy the limits of aging.
A major breakthrough in understanding the longevity of Greenland sharks came from a research team led by Julius Nielsen, a marine biologist at the University of Copenhagen. Nielsen and his colleagues conducted a study that revealed a Greenland shark estimated to be at least 272 years old, with some models suggesting an upper age limit of nearly 500 years.
This finding shattered previous records, surpassing the known lifespan of the 211-year-old bowhead whale, which had long been considered the longest-lived vertebrate.
Rewriting the Rules of Aging: New Chromatin Discovery Challenges Conventional Wisdom
Published in the Journal of the American Chemical Society, the research by scientists at King’s College London and their collaborators suggests that chromatin—the complex of DNA
DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).
Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems
This study develops organ-specific aging models using blood proteomics data from 53,000 UK Biobank participants. These models predict organ-specific diseases and risk of death and reveal that chronic diseases reflect faster aging in specific organs. Different lifestyles affect organ aging differently.
Digital Echo
The concept of computational consciousness and its potential impact on humanity is a topic of ongoing debate and speculation. While Artificial Intelligence (AI) has made significant advancements in recent years, we have not yet achieved a true computational consciousness capable of replicating the complexities of the human mind.
AI technologies are becoming increasingly sophisticated, performing tasks that were once exclusive to human intelligence. However, fundamental differences remain between AI and human consciousness. Human cognition is not purely computational; it encompasses emotions, subjective experiences, self-awareness, and other dimensions that machines have yet to replicate.
The rise of advanced AI systems will undoubtedly transform society, reshaping how we work, communicate, and interact with the digital world. AI enhances human capabilities, offering powerful tools for solving complex problems across diverse fields, from scientific research to healthcare. However, the ethical implications and potential risks associated with AI development must be carefully considered. Responsible AI deployment, emphasizing fairness, transparency, and accountability, is crucial.
In this evolving landscape, ETER9 introduces an avant-garde and experimental approach to AI-driven social networking. It redefines digital presence by allowing users to engage with AI entities known as ‘noids’ — autonomous digital counterparts designed to extend human presence beyond time and availability. Unlike traditional virtual assistants, noids act as independent extensions of their users, continuously learning from interactions to replicate communication styles and behaviors. These AI-driven entities engage with others, generate content, and maintain a user’s online presence, ensuring a persistent digital identity.
ETER9’s noids are not passive simulations; they dynamically evolve, fostering meaningful interactions and expanding the boundaries of virtual existence. Through advanced machine learning algorithms, they analyze user input, adapt to personal preferences, and refine their responses over time, creating an AI representation that closely mirrors its human counterpart. This unique integration of AI and social networking enables users to sustain an active online presence, even when they are not physically engaged.
The advent of autonomous digital counterparts in platforms like ETER9 raises profound questions about identity and authenticity in the digital age. While noids do not possess true consciousness, they provide a novel way for individuals to explore their own thoughts, behaviors, and social interactions. Acting as digital mirrors, they offer insights that encourage self-reflection and deeper understanding of one’s digital footprint.
As this frontier advances, it is essential to approach the development and interaction with digital counterparts thoughtfully. Issues such as privacy, data security, and ethical AI usage must be at the forefront. ETER9 is committed to ensuring user privacy and maintaining high ethical standards in the creation and functionality of its noids.
ETER9’s vision represents a paradigm shift in human-AI relationships. By bridging the gap between physical and virtual existence, it provides new avenues for creativity, collaboration, and self-expression. As we continue to explore the potential of AI-driven digital counterparts, it is crucial to embrace these innovations with mindful intent, recognizing that while AI can enhance and extend our digital presence, it is our humanity that remains the core of our existence.
As ETER9 pushes the boundaries of AI and virtual presence, one question lingers:
— Could these autonomous digital counterparts unlock deeper insights into human consciousness and the nature of our identity in the digital era?
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Urolithin A Rejuvenates Old Stem Cells (Clip)
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IPS Cells Give New Hope Against Eye Diseases / The Government of Japan
Dr. Masayo Takahashi graduated from Kyoto University’s Faculty of Medicine in 1986. In 1992, she completed her Ph.D. in Visual Pathology at Kyoto University’s Graduate School of Medicine. She first worked as a clinician, but later became interested in research following her studies in the United States in 1995. In 2005, her lab became the first in the world to successfully differentiate neural retina from embryonic stem cells. She is currently the project leader of the Laboratory for Retinal Regeneration at the RIKEN Center for Developmental Biology (CDB).
Recently in Japan they restored vision of three people using puliportent stem cells.
Then, in March 2017, Dr. Takahashi and her team made another important step forward. While the 2014 surgery had used cells generated from the patient’s own tissues, Dr. Takahashi and her team succeeded this time in the world’s first transplantation of RPE cells generated from iPS cells that originated from another person (called “allogeneic transplantation”) to treat a patient with wet-type AMD. Currently, the patient is being monitored for the possibility of rejection, which is a risk of allogeneic transplantation. Regarding the significance of the operation, Dr. Takahashi explains that “allogeneic transplantation substantially reduces the time and cost required in producing RPE cells, creating opportunities for even more patients to undergo surgeries. Hearing patients’ eager expectations firsthand when working as a clinician has also been a significant motivation.”
Dr. Takahashi’s team is currently making preparations for clinical studies that will target retinitis pigmentosa, a hereditary eye disease, by transplanting photoreceptor cells. “Having my mind set on wanting to see applications of iPS cells in treatments as quickly as possible, I have been actively involved in the creation of the regulations for their practical applications in regenerative medicine. In Japan, where clinical studies and clinical trials can be conducted at the same time, there is significant merit in the fact that research can be carried out by doctors who also work in medical settings. This helps ensure that they proceed with a sense of responsibility and strong ethics. Our advanced clinical studies have attracted the attention of researchers working in regenerative medicine in various countries. I intend to maintain a rapid pace of research so that we can treat the illnesses of as many patients as possible.”
Nicotinamide Riboside Supplementation Alleviates Testicular Aging Induced by Disruption of Qprt‐Dependent NAD+ De Novo Synthesis in Mice
In this study, we have demonstrated the crucial role of NAD+ homeostasis, particularly through the de novo synthesis pathway mediated by Qprt, in maintaining spermatogenesis with age. The deletion of Qprt led to progressive declines in NAD+ levels, particularly after 6 months of age, which were associated with significant defects in germ cell survival and mitochondrial function in spermatocytes. These disruptions manifested as impaired progression through meiosis, defective DNA double-strand break repair, and abnormal meiotic sex chromosome inactivation. Our findings also highlight the therapeutic potential of NAD+ precursor supplementation, as nicotinamide riboside effectively rescued the observed spermatogenic abnormalities in Qprt-deficient mice, emphasizing the importance of NAD+ in reproductive health and aging.
NAD+ can be synthesized through three pathways: the Preiss-Handler pathway, the salvage pathway, and the de novo pathway (Liu et al. 2018 ; Harjes 2019). In the de novo pathway, the essential amino acid tryptophan serves as a substrate, with Qprt catalyzing the formation of nicotinic acid mononucleotide, which is subsequently converted into NAD+ via a series of enzymatic reactions in the Preiss-Handler pathway. Coordinated regulation of these three pathways is crucial for maintaining intracellular NAD+ levels, which are essential for cellular function, a decline in NAD+ levels can lead to various pathological and physiological conditions (Minhas et al. 2019 ; Zhang et al. 2019a). In this study, we identified that Qprt, the rate-limiting enzyme in the NAD+ de novo synthesis pathway, is predominantly expressed in spermatocytes within the testes.
Taking omega-3 supplements may slow down aging, a new study finds
An international team of scientists, including researchers from Harvard University and the University of Zurich, analyzed clinical trial results 777 elderly Swiss adults to test the potential anti-aging benefits of supplements and exercise.
While there’s no perfect way to measure biological aging, the researchers used tools that help measure age-related decline in the cells and organs, including factors like brain health and heart health.
They looked at participants who underwent one of eight longevity treatments over three years, including exercising and supplementing omega-3s, vitamin D, or both.