Lifeboat Foundation

A study suggests cardiorespiratory fitness is linked to a longer life, suggesting no exercise is worse for health than smoking or diabetes.

Many mutations accumulate in the esophagus as we age.

Scientists at the MRC Cancer Unit of the Wellcome Sanger Institute and other departments of the University of Cambridge discovered that healthy esophageal tissue accumulates very high numbers of mutations with age, to the point that, by the time middle age is reached, it is likely to contain more cells with a particular mutation than cells without it [1].

Abstract

Continue reading “Mutations Accumulate in Healthy Esophageal Tissue With Age” »

Judith Campisi as a speaker for the 2019 Undoing Aging Conference.

At Lawrence Berkeley National Laboratory and at the Buck Institute for Research on Aging, Dr. Judith Campisi established a broad program to understand the relationship between aging and age-related disease.

Judith Campisi says: “Aging research has entered an era of unprecedented hope for interventions that can prevent, delay and, in some cases, reverse much of the functional decline that is a hallmark of aging. There is still a lot of research to be done! I am delighted to be among the speakers at Undoing Aging 2019, where I will discuss the opportunities and challenges of our recent research.”

Continue reading “We are happy to announce Dr” »

To paraphrase Churchill’s words following the Second Battle of El Alamein: Google’s announcement about their new venture to extend human life, Calico, is not the end, nor even the beginning of the end, but it is, perhaps, the end of the beginning.

(MORE: Google vs. Death)

Since the dawn of civilization, humanity has been enslaved by the knowledge that no lifestyle choice, no medicine, no quirk of fate can enable anyone to live for more than a few decades without suffering progressive, inexorable decline in physical and mental function, leading inevitably to death. So soul-destroying has this knowledge been, for almost everyone, that we have constructed our entire society and world view around ways to put it out of our minds, mostly by convincing ourselves that the tragedy of aging is actually a good thing. And why not? After all, why be preoccupied about something one cannot affect?

Continue reading “Google’s Calico: the War on Aging Has Truly Begun” »

Today we are delighted to announce there is to be a third fund match for the NAD+ Mouse Project!

Today, we are delighted to announce that there is to be a third funding match for the NAD+ Mouse Project!

Dr. David Sinclair will be personally matching the next $5000 in donations for the last 10 days of the campaign to help reach the final $60,000 goal. Now, that is what we call a devoted scientist!

Continue reading “David Sinclair Supports NAD+ Mouse Project with a 5k Fund Match” »

A team of researchers led by Principal Investigator Dr. Jan Gruber from Yale-NUS College has discovered a combination of pharmaceutical drugs that not only increases healthy lifespan in the microscopic worm Caenorhabditis elegans (C. elegans), but also delays the rate of ageing in them, a finding that could someday mean longer, healthier lives for humans.

The study, published in the peer-reviewed international journal Developmental Cell on 8 October 2018, lays crucial groundwork for further research into designing drug combinations that produce the same effect in mammals.

“Many countries in the world, including Singapore, are facing problems related to ageing populations,” said Dr. Gruber, whose lab and research team made the discovery. “If we can find a way to extend healthy lifespan and delay ageing in people, we can counteract the detrimental effects of an ageing population, providing countries not only medical and economic benefits, but also a better quality of life for their people.”

Cancer is the poster child of age-related diseases, and a recent study sheds light on why the risk of cancer rises dramatically as we age.

Abstract

For many cancer types, incidence rises rapidly with age as an apparent power law, supporting the idea that cancer is caused by a gradual accumulation of genetic mutations. Similarly, the incidence of many infectious diseases strongly increases with age. Here, combining data from immunology and epidemiology, we show that many of these dramatic age-related increases in incidence can be modeled based on immune system decline, rather than mutation accumulation. In humans, the thymus atrophies from infancy, resulting in an exponential decline in T cell production with a half-life of ∼16 years, which we use as the basis for a minimal mathematical model of disease incidence. Our model outperforms the power law model with the same number of fitting parameters in describing cancer incidence data across a wide spectrum of different cancers, and provides excellent fits to infectious disease data.

Continue reading “Dr. Sam Palmer – Thymic Involution and Cancer Risk” »

In support of the NAD+ Mouse Project over at Lifespan.io, Dr. David Sinclair will be doing an AMA on Reddit Futurology Tuesday, October 23, 2018 from 11:00 – 12:00 AM EDT. Dr. Sinclair will be answering questions from the community about his work with NAD+ biology, Sirtuins, and why the NAD+ Mouse Project is important for aging research. To ask your question please visit the AMA thread on Reddit Futurology here.

For those not familiar with NAD+ biology we did the NAD+ World series recently which explores this area of the biology of aging. We also took a look at why NAD+ appears to decline as we age and what is one of the most likely reasons for this.

Continue reading “Dr. David Sinclair AMA at Reddit Futurology” »

Pharmacist turned Entrepreneur with Ira Pastor? Ep. 241