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Category: life extension – Page 356

Pilot Study Results Suggest Epigenetic Age Reversal

3 things:

1. The company claims that it has been successful in reducing the epigenetic age of participants(17 people) by an average of 8.5 years with its dietary supplement Rejuvant.

2. Obviously, this has yet to be proven conclusively in human trials, and the company is busy preparing to launch a larger-scale trial later this year to that end.

3. I want to know if it reset telomeres.

Today, we want to highlight a press release from Ponce de Leon Health that talks about the results of a pilot consumer trial that the company has recently concluded. The company claims that it has been successful in reducing the epigenetic age of participants by an average of 8.5 years with its dietary supplement Rejuvant.

Ponce de Leon Health initially worked with Dr. Brian Kennedy, who was, at the time, based at the Buck Institute for Research on Aging, searching for compounds that were generally recognized as safe (GRAS) but that had the potential to influence aging in mammals. The company screened over 300 GRAS compounds and identified compounds that could modulate a number of pathways that are linked to aging. These compounds affected the mTOR pathway, blocked the proinflammatory secretions made by senescent cells, affected genomic stability pathways, aided in ammonia detoxification, and supported protein homeostasis.

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Nanotechnology applied to medicine: The first liquid retina prosthesis

Research at IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology) has led to the revolutionary development of an artificial liquid retinal prosthesis to counteract the effects of diseases such as retinitis pigmentosa and age-related macular degeneration that cause the progressive degeneration of photoreceptors of the retina, resulting in blindness. The study has been published in Nature Nanotechnology.

The study represents the state of the art in retinal prosthetics and is an evolution of the planar artificial retinal model developed by the same team in 2017 and based on organic semiconductor materials (Nature Materials 2017, 16: 681–689).

The ‘second generation’ artificial retina is biomimetic, offers and consists of an aqueous component in which photoactive polymeric nanoparticles (whose size is 350 nanometres, thus about 1/100 of the diameter of a hair) are suspended, and will replace damaged photoreceptors.

Circular RNA found to make fruit flies live longer

Ribonucleic acid, or RNA, is part of our genetic code and present in every cell of our body. The best known form of RNA is a single linear strand, of which the function is well known and characterized. But there is also another type of RNA, so-called “circular RNA,” or circRNA, which forms a continuous loop that makes it more stable and less vulnerable to degradation. CircRNAs accumulate in the brain with age. Still, the biological functions of most circRNAs are not known and are a riddle for the scientific community. Now scientists from the Max Planck Institute for Biology of Aging have come one step closer to answer the question what these mysterious circRNAs do: one of them contributes to the aging process in fruit flies.

Carina Weigelt and other researchers in the group led by Linda Partridge, Director at the Max Planck Institute for Biology of Aging, used to investigate the role of the circRNAs in the aging process. “This is unique, because it is not very well understood what circRNAs do, especially not in an aging perspective. Nobody has looked at circRNAs in a longevity context before,” says Carina Weigelt who conducted the main part of the study. She continues: “Now we have identified a circRNA that can extend lifespan of fruit flies when we increase it, and it is regulated by signaling.”

Human Trials of Plasma Exchange

Animal experiments demonstrating the anti-aging effects of exchanging young blood plasma for old have been prominent in the last two months. Several groups are saying it’s time to translate their findings into human trials. But I’ve recently learned that others have been doing this for several years. What can we learn from their results to guide the next steps in experimentation?

I had never heard of Grifols, the Spanish pharmaceutical company that is the world’s largest supplier of albumin. Since 2005, Grifols has been quietly funding world leaders in plasma exchange research in humans. Albutein ® is their brand-name solution of human albumin.

Last month, the first results of the Grifol’s AMBAR trial were released. (AMBAR stands for A lzheimer’s M odulation B y A lbumin R eplacement). It was a much larger-scale phase 2.5 trial, with 496 subjects recruited from sites in Spain and USA, and treated for 14 months. A single treatment consisted of removing 2.5 to 3 litres of blood (more than half the body’s inventory) and replacing it with Albutein. Patients began with 6 weekly treatments, and thereafter there were 12 monthly smaller plasma replacements (0.7 litres), again with Albutein.

Happy birthday to the World most important Entrepreneur ( Olorogun Elon Musk)

Happy birthday to the World most important Entrepreneur (Olorogun Elon Musk). We at the Ogba Educational Clinic and Artificial intelligence Hub celebrate and wish to immortalize you by Setting up a club after you (The Elon Musk Club). This is in line with our vision to create small Elon’s that would eventually outdo you from Africa.

Building a Factory for Human Organs

Dean Kamen, the inventor of the Segway, is currently spearheading a project to convert part of the old New Hampshire textile plant into a factory for lab-grown lungs, livers, and other organs for transplantation — and he doesn’t think it’ll take long to do it.

The nonprofit is like a club for tissue engineering and regenerative medicine researchers. Groups must have something to offer in order to join (money, equipment, experience), but once a part of ARMI, they gain access to the other members’ research and resources.

Stem Cells: The Key to Reversing Biological Age

Fantastic article on Dr Yuancheng Ryan Lu’s age reversal experiment.

“ It suggests that it is entirely possible to reverse aging in cells with the use of a molecular mechanism already present in the cells. And so, scientists are now off to the races in the hopes of finding this cellular mechanism, and ways to activate this correction system in living beings…”

In 2006, Dr. Shinya Yamanaka, a Japanese stem cell researcher, published his paper on induced pluripotent stem cells, and it changed the medical world. Dr. Yamanaka had found a way to convert a mature skin cell into a stem cell by injecting just a few genes. And for this, Dr. Yamanaka received the Nobel Prize in Physiology or Medicine in 2012, sharing it with another Sir John B. Gurdon, who found another method of inducing pluripotency.

Thirteen years after this paper was published (in 2019), Dr. Yuancheng Lu from the Sinclair Lab at Harvard University authored another paper (still being peer-reviewed) where he had used Dr. Yamanaka’s breakthrough to reverse aging.

To first explain what stem cells are (for those of you that don’t have much biology experience), we’re going to go back in time to when you were just a small mass of cells in your mother’s womb.