An experimental drug reversed age-related declines in memory and mental flexibility in old mice after just a few doses, according to a study by researchers from the University of California, San Francisco (UCSF).
The drug, ISRIB, has previously been shown in other studies to restore normal cognitive function in mice after traumatic brain injury, enhance memory in healthy mice and mice with Down syndrome, as well as prevent noise-related hearing loss.
University of rochester — working at the intersection of aging, DNA repair, and cancer.
Dr. Vera Gorbunova is the Doris Johns Cherry Professor, in the Department of Biology, and Co-director, Rochester Aging Research Center, at University of Rochester.
Her research is focused on understanding the mechanisms of longevity and genome stability and on the studies of exceptionally long-lived mammals.
Dr. Gorbunova earned her B.Sc. degrees at Saint Petersburg State University, Russia, and her Ph.D. at the Weizmann Institute of Science, Israel.
Dr. Gorbunova was instrumental in pioneering the comparative biology approach to studying aging and identifying rules that control the evolution of tumor suppressor mechanisms depending on the species lifespan and body mass.
Hello rejuvenation friends! Did you know that Heales, the Belgian entity led by Didier Coeurnelle, is financing two very interesting experiments with the great rejuvenation scientists Harold Katcher and Rodolfo Goya in order to test if Elixir (in the case of Katcher) and plasma of young rats (in the case of Goya) are capable to considerably extend the lifespan of rats? Today I found out on Google that six days ago, Didier published this article in Heales website: https://heales.org/wp-content/plugins/multisite-language-switcher/flags/. In the article, Didier explains in depth both experiments, and put the links to the detailed protocol of the experiments, in two Word files. It’s incredible the power of the collaboration of people who are enthusiastic of rejuvenation science, such as Didier, Harold and Rodolfo. I don’t know if the experiment will extend considerably the rats lives, but it seems that these two experiments deserve a close look from the rejuvenation field.
Today, in spite of the gigantic progress in medicine and research, we still do not know how to be healthy beyond about 85 years of age.
German scientists are researching a method to produce hydrogen using light and photoactive compounds on an organic chemical basis.
Hydrogen is considered to be one of the alternative energy sources of the future. So far, however, the costly and energy-intensive production process has been a major problem with regard to the environmental friendliness of this substance, which is in itself CO2 neutral. For this reason, increasing numbers of scientists around the world are researching other methods of producing hydrogen: from algae, for example. (IO reported). Scientists in Germany at the Friedrich Schiller University, the Leibniz Institute for Photonic Technologies (Leibniz IPHT) and the University of Ulm have taken inspiration from nature for their method of producing hydrogen.
To do so, the team from the “CataLight” Collaborative Research Center at the Universities of Jena and Ulm has combined new organic dyes with non-precious metal catalyst molecules that release gaseous hydrogen in water when irradiated with light. This substitute has shown a remarkable impact in terms of longevity and effect after excitation by visible light, they write in their study, published in Chemistry – A European Journal.
Photosynthesis as inspiration
In nature, sunlight is most effectively stored in chemical bonds through photosynthesis, because the light-collecting and reactive complexes in the thylakoid membrane are fixed in chloroplasts. The researchers led by Prof. Felix Schacher have achieved this type of arrangement with the help of polymers that interact with both hydrophilic and hydrophobic substances. These charged, so-called graft copolymers are produced artificially.
Here’s my latest video!
The Hallmarks of Aging are well established, but what is less discussed is the impact of microbes and/or microbial products. The bacterial metabolite, LPS, increases during aging, and it negatively impacts mitochondrial function, thereby demonstrating a role for microbial products on one of the Hallmarks of Aging, mitochondrial dysfunction.
I am sure you know weak bones break more easily, and the older you get the worse any extended periods of inactivity are, on not just your present health and well being, but also your longevity.
So whether you are lifting free weights for the fun of it, using your body weight in a home scenario or engaging in daily activities you know are physically taxing, you should really be incorporating some form of strength training in your plans for longevity.
Get your copy of Cyberpunk 2077 here:
http://cyberpunk.net/buy.
Sources & further reading:
https://sites.google.com/view/sources-mindupload.
The desire to be free from the limits of the human experience is as old as our first stories. We exist in an endless universe, only bound by the laws of physics and yet, our consciousness is trapped in mortal machines made of meat. With the breathtaking explosion of innovation and progress, for the first time the concept of leaving our flesh piles behind and uploading our minds into a digital utopia seems possible. Even like the logical next step on our evolutionary ladder.
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We interviewed a group of Russian biohackers who performed a plasma dilution experiment on themselves. This experiment, the first of its kind, was based on previous mouse studies by Drs. Irina and Michael Conboy.
Some molecules, while essential for various body functions, can be harmful when overproduced. Inflammatory cytokines, such as transforming growth factor beta 1 (TGF-ß1), interleukin 6 (IL6), and tumor necrosis factor alpha (TNFa) are good examples. The concentration of these cytokines in our blood rises with age, provoking inflammaging, the chronic inflammation that is associated with aging. It has been long speculated that reducing the harmful molecules in circulation can attenuate aging.
Nice lecture with both technical info and analogy.
Latest study from David Sinclair’s lab have used cellular reprogramming to restore vision in aged mice & more! Suggests reversing aging *may* be possible.
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TIMESTAMPS;
Intro — 00:00
Aging is loss of information — 00:45
Correction device & epigenetics — 02:49
Yamanaka factors & OSKM — 04:45
Study results from Sinclair lab — 07:25
Aging reversed? — 10:29
Working model — 12:00
Cellular reprogramming in humans? — 12:36.
REFERENCES;
Dr. Steve Horvath, a professor of genetics and biostatistics at UCLA, has found a way to measure biological aging – a type of “clock” – based on the methylation pattern of an organism’s genome. Methylations are biochemical processes that modify the activity of a DNA segment without changing its sequence – a type of epigenetic change. This video primer explains the basics of epigenetic clocks, the topic of our interview with Dr. Steve Horvath, coming soon!
Get the show notes here:
https://www.foundmyfitness.com/episodes/epigenetic-clock/
Episode highlights:
• 00:00:09 — A person’s risk of disease is more dependent on their biological age than their chronological age.
• 00:00:09 — Epigenetics refers to processes that can affect gene expression without changing the DNA sequence. Methylation is a type of epigenetic change that occurs over a lifetime in a predictable way and can be used to measure biological age.
• 00:01:17 — The Horvath clock can accurately predict a person’s chronological age based on only the epigenetic information in their blood.
• 00:01:54 — The GrimAge clock can predict the risk and time of onset of cancer, heart disease, and death.
• 00:02:19 — Certain drugs can reverse a person’s epigenetic age, but the effects on biological age are unknown.
• 00:03:09 — The discovery of an anti-aging drug is on the horizon.