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Levine’s Biological age calculator is embedded as an Excel file in this link from my website:
An epigenetic biomarker of aging for lifespan and healthspan.
https://pubmed.ncbi.nlm.nih.gov/29676998/
Underlying features of epigenetic aging clocks in vivo and in vitro.
https://pubmed.ncbi.nlm.nih.gov/32930491/
Population Specific Biomarkers of Human Aging: A Big Data Study Using South Korean, Canadian, and Eastern European Patient Populations.
https://pubmed.ncbi.nlm.nih.gov/29340580/
In this episode of Longevity by Design, our hosts, Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD, are joined by Dr. George Church, Professor of Genetics at Harvard Medical School. Tune in as Dr. George Church discusses the many roles of gene therapy, including its ability to reverse age-related diseases.
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Summary: Researchers used optogenetics techniques to stimulate specific brain areas to increase neurogenesis and the production of neural stem cells to improve memory, cognition, and emotional processing in animal models.
Source: UNC Health Care.
We humans lose mental acuity, an unfortunate side effect of aging. And for individuals with neurodegenerative conditions such as Alzheimer’s and Parkinson’s, the loss of cognitive function often accompanied by mood disorders such as anxiety is a harrowing experience. One way to push back against cognitive decline and anxiety would be to spur the creation of new neurons.
Circa 2014
As a seventh grader, I was lucky to land the job of ball boy for the Brooklyn Dodgers during their annual late-March exhibition games in Miami. The experience left me with fond memories — of Roy Campanella smoking a cigar as he stroked line drives in the batting cage, of a young Sandy Koufax throwing harder than seemed humanly possible and of an aging Jackie Robinson struggling to remain in the lineup.
Oddly, however, my most vivid memory is of the Dodgers’ longtime batboy as he sat in the locker room producing autographed baseballs. He’d twist his hand at odd angles as he scrawled replicas of the signatures of Duke Snider, Pee Wee Reese and other Dodger legends. To my untrained eye, the balls he inscribed were indistinguishable from those signed by the players themselves.
Handwriting experts probably could have identified his forgeries without difficulty, but technology has progressed considerably since then. In many domains, perhaps even including signed baseballs, it’s becoming possible to produce essentially perfect replicas of once rare and expensive things.
Hey it’s Han from WrySci-HX going over the breakthroughs of scientists rejuvenating skin cells of middle aged donors by several decades, overcoming complete paralysis in just one day, and more! See below ↓↓↓
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Summary: Supplementing a diet with Ascidiacea, or sea squirts, reversed some of the main signs of aging in mouse models.
Source: Xi’an jiaotong-Liverpool University.
If you have ever looked in the mirror and seen graying hair and wrinkles or forgotten the name of a close friend, you’d be forgiven for wishing for a pill that could slow or even reverse the effects of aging.
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Papers referenced in the video:
A Physiology Clock for Human Aging (preprint)
https://www.biorxiv.org/content/10.1101/2022.04.14.488358v1
Predicting Age by Mining Electronic Medical Records with Deep Learning Characterizes Differences between Chronological and Physiological Age.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716867/
Spirometry Reference Equations for Central European Populations from School Age to Old Age.
https://pubmed.ncbi.nlm.nih.gov/23320075/
An Integrated, Multimodal, Digital Health Solution for Chronic Obstructive Pulmonary Disease: Prospective Observational Pilot Study.
https://pubmed.ncbi.nlm.nih.gov/35142291/
Scientists have momentarily restored a faint twinkle of life to dying cells in the human eye.
In order to better understand the way nerve cells succumb to a lack of oxygen, a team of US researchers measured activity in mouse and human retinal cells soon after their death.
Amazingly, with a few tweaks to the tissue’s environment, they were able to revive the cells’ ability to communicate hours later.
Telomeres are “caps” of non-coding DNA sequences present at both tips of our chromosomes, which are extremely important in the aging process. These caps protect our DNA as cells go through various life cycles of replication, however, each time a cell divides these telomeres are shortened and eventually contribute to disease and cellular aging.
Now, exciting new research published in the Journal PNAS has shown that an experimental gene therapy could be used to halt the shortening of these telomere caps in mice and by doing so increase the life span of these animals by up to 41 percent compared to controls.
Telomere length can be considered a marker of biological age and its shortening is a hallmark of a process called cellular senescence, which limits the replication of DNA in old damaged cells. As we age, telomere caps become shorter and shorter until the cell’s DNA becomes vulnerable to damage by cellular stresses that could lead to diseases such as cancer. Or the cell could ultimately reach senescence where it will no longer be able to replicate and so contribute to the aging process. For scientists looking at how to slow or even reverse aging, telomeres are of great interest.