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People Who Live Beyond 105 Have Better DNA Repair

Not sure how novel.


People who live beyond 105 years are more efficient at repairing DNA, according to a study published today in eLife.

Paolo Garagnani and colleagues, in collaboration with several research groups in Italy and a research team led by Patrick Descombes at Nestlé Research in Lausanne, Switzerland, recruited 81 semi-supercentenarians (those aged 105 years or older) and supercentenarians (those aged 110 years or older) from across the Italian peninsula. They compared these with 36 healthy people matched from the same region who were an average age of 68 years old.

They took blood samples from all the participants and conducted whole-genome sequencing to look for differences in the genes between the older and younger group. They then cross-checked their new results with genetic data from another previously published study which analyzed 333 Italian people aged over 100 years old and 358 people aged around 60 years old.

Scientists find mechanism that eliminates senescent cells

Scientists at UC San Francisco are learning how immune cells naturally clear the body of defunct—or senescent—cells that contribute to aging and many chronic diseases. Understanding this process may open new ways of treating age-related chronic diseases with immunotherapy.

In a healthy state, these —known as invariant Natural Killer T (iNKT) cells—function as a surveillance system, eliminating cells the body senses as foreign, including , which have irreparable DNA damage. But the iNKT cells become less active with age and other factors like obesity that contribute to chronic disease.

Finding ways to stimulate this natural surveillance system offers an alternative to senolytic therapies, which to date have been the primary approach to removing senescent cells. It could be a boon to a field that has struggled with how to systemically administer these senolytics without .

17 Best Longevity Conferences and Events for 2021

We’ve updated our list of top longevity conferences and events for 2021, adding 4 new ones and removing 3 that are no longer happening:


Update 5/10/2021: This post has been updated since we originally published it in August 2020. Several new longevity conferences have been added and several which are no longer happening have been removed.

Affiliate Disclaimer: Longevity Advice is reader-supported. When you buy something using links on our site, we may earn a few bucks.

Usually, when you approach a random stranger and immediately begin talking about things like DNA methylation rates and NAD+ precursors, you’re lucky if all you get is a weird look.

My Theory & The Future Of Aging | Prof George Church Interview Series Episode 1

7:01 they talk about Church’s comments of ending aging by 2030. Also this appears to be a part one.


In this video Professor Church talks about his theory of aging and touches on his ideas on the future of aging.

George Church is the Robert Winthrop Professor of Genetics at Harvard Medical School, a Professor of Health Sciences and Technology at Harvard and MIT. Professor Church helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. He has co-authored 580 paper, 143 patent publications & the book “Regenesis”.

George Church Links.
Professor Church’s Lab at Harvard.
https://arep.med.harvard.edu/

Professor Church’s Book on Amazon.

Homocysteine Increases During Aging, But Can Be Reduced With Diet And Targeted Supplementation

Papers referenced in the video:

Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway:
https://pubmed.ncbi.nlm.nih.gov/32130883/

Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels:
https://pubmed.ncbi.nlm.nih.gov/27567458/

Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study:
https://pubmed.ncbi.nlm.nih.gov/7474221/

Total plasma homocysteine values among elderly subjects: findings from the Maracaibo Aging Study:
https://pubmed.ncbi.nlm.nih.gov/16959233/

Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies:

María Blasco sobre retrasar el envejecimiento y extender la vida (with S/T in English)

Excerpts from an interview with Dr. María Blasco, Director of the Spanish National Cancer Research Center (CNIO), where she covers how telomeres shortening induce aging, how artificially lenghtening telomeres has proven to extend lifespan in animal models like mice, and what the impact will be in human health and lifespan once the techniques (gene therapies) get effectively translated into humans.

The interview took place on May 6, 2021 as part of a program organized by the Madrid Planetarium, to contribute to a better orientation of the students of the last years of high school when deciding which university studies further engage.

The language used is not intended for an audience of scientists but rather accessible to all audiences.

The entire interview was made in Spanish but I ADDED S/T in ENGLISH FOR THE EXCERPTS SHOWN in this video.

In the description is the link to the entire interview which as I said was made in Spanish.


Super Long HealthSpans: In The Making

0:00 — Title.
0:35 — Into.
1:15 — Super People of The Future.
1:46 — Neal VanDeree ‘Living Long Healthy Lives Will be Possible’ — https://www.churchofperpetuallife.org/https://www.youtube.com/user/COPL18
3:24 — Dr. Bill Andrews ‘Super Wonderful Future’ — https://www.sierrasci.com/
6:27 — Selim Bakırcı ‘1000 years long life’
6:58 — Rodrigo Guinea ‘Great Responsibility’ — https://www.linkedin.com/in/rodguinea/
9:22 — Significant Research.
9:40 — Significant Research — Liz Parrish — https://bioviva-science.com/
10:44 — Significant Research — Brent Nally — https://longevityplan.net/https://www.linkedin.com/in/brentnally/https://www.youtube.com/user/BrentAltonNally.
13:10 — Significant Research — Cain Hillier — https://www.linkedin.com/in/cain-hillier-50571a18a/
14:43 — Significant Research — Chris Curwen — https://www.linkedin.com/in/chris-curwen-67144b169/
17:16 — The Threshold Times.
18:41 — The Threshold Times — Brent Nally.
21:35 — The Threshold Times — Chris Curwen
24:25 — The Threshold Times — Liz Parrish.
26:21 — The Threshold Times — Nicolas Chernavsky
https://www.linkedin.com/in/nicolas-chernavsky-25265835/https://www.youtube.com/channel/UCUASjdn96BRlGVytmbDgRRA
27:00 — The Threshold Times — Josh Martin.
27:42 — The Threshold Times — Cain Hillier.
28:50 — The Threshold Times — Vikram Pandya — https://www.linkedin.com/in/vikrampandya/
31:24 — Ageing Is a Disease.
32:49 — Ageing Is a Disease — Neal VanDeree.
34:09 — Ageing Is a Disease — Dr. Bill Andrews.
37:48 — Ageing Is a Disease — Liz Parrish.
39:28 — Ageing Is a Disease — Brent Nally.
42:10 — Ageing Is a Disease — Aaron King.
44:44 — Ageing Is a Disease — Lukas Vismantas — https://www.linkedin.com/in/lukas-vismantas/?originalSubdomain=dk.
46:07 — Ageing Is a Disease — Cain Hillier.
48:02 — Ageing Is a Disease — Chris Curwen.
50:23 — Ageing Is a Disease — Nicolas Chernavsky.
52:49 — The Big Times.
54:40 — The Big Times — Dr. Bill Andrews.
56:52 — The Big Times — Liz Parrish.
59:16 — The Big Times — Brent Nally.
01:03:50 — The Big Times — Nicholas Mohnacky — https://www.bundleiq.com/https://www.linkedin.com/in/mohnacky/
01:05:00 — The Big Times — Bolek Kerous — https://www.linkedin.com/in/bolekkerous/https://www.youtube.com/channel/UCSpv8MA3xPskco9qdIBeNuQ
01:08:24 — The Big Times — Nicolas Chernavsky.
01:08:58 — The Big Times — Chris Curwen.
01:09:48 — The Big Times — Nicolas Chernavsky.
01:11:19 — The Big Times — Jeremy Rumble — https://www.linkedin.com/in/jeremy-rumble-42910b38/
01:12:22 — The Big Times — Jakub Czubak — https://www.linkedin.com/in/jakub-czubak-603624a9/
01:14:20 — The Big Times — Josh Martin.
01:14:50 — The Big Times — Nicolas Chernavsky.
01:20:15 — The Big Times — Brent Nally.
01:22:09 — Ending.

Omitting natural disasters like an asteroid smashing Earth or a volcano eruption we can say that improving human health and condition is the most important safety case/concern and the fundamental thing to consider and accomplish on our way to be super cosmic humanity. Significant health improvements will free us from all diseases, allow us to develop superhuman intelligence, let us totally self-realize, and consequently, help realize the infinity in the matter for the common good. However intensively we focus on intelligence, it is not possible to experience its natural consequence or the next level of its advancement/evolution if there is no good health. Coherent and consistent collective mind continuum experience is not possible without super health (Healthy life that is free from the danger of uncontrollable death). Our bodies are short-timed and not strong enough to hold up the Earth-Gravity-Geometry sized/adjusted thoughts that are necessary to naturally manage and effectively inhabit our planet.

Our lives often seem to be episodic where the memories and thoughts get lost — one might say that this is the matter of learning and perfecting the mind but this is as far from the truth as big is the number of people who struggle with having a comprehensive perspective, not because of the lack of will to do so but because of the lack of comfort of having good health and life conditions. The comfort of the living space we got ourselves on the planet after the ages of technological developments and evolution is not a direct effect of our intelligence — The main factor for human intelligence is common health. Weak wiring of the nervous system makes it difficult to communicate progress, and therefore, build with the big human intelligence. We need to constructively adjust our metabolic paths, understand and fix our cells, learn to touch and manipulate our DNA, improve internal signaling, and get super healthy if we want to use real great human intelligence to build a wonderful future. The house we can create on the fundaments of super long healthspans will be the first of its kind and magnitude — I hope to give a good vision of the new world in order to get the good motivation to proceed in life and actually get there.

People who live past 105 years old have genes that stop DNA damage

People who reach a very old age may have their genes to thank. Genetic variants that help to prevent DNA mutations and repair any that do occur have been found in supercentenarians and semi-supercentenarians – people who reach the ages of 110 and 105, respectively.

“DNA repair mechanisms are extremely efficient in these people,” says Claudio Franceschi at the University of Bologna in Italy. “It is one of the most important basic mechanisms for extending lifespan.”

Founder of Forever Healthy doubles down on mission to accelerate rejuvenation biotechnology

That’s good funding.


Berlin, Gerrmany — Michael Greve, founder of the Forever Healthy Foundation and owner of Kizoo Technology Ventures, announced today that he will make available an additional €300 million to be invested in rejuvenation biotech.

The funds, to be deployed via Kizoo, will be used to create and support more startups in the rejuvenation space. They will also allow Kizoo to maintain a strong commitment to its key startups during follow-up rounds and to advance the therapies from clinical development to public availability.

With this €300 million commitment, Michael Greve and Kizoo double down on their mission to accelerate the advent of rejuvenation biotechnology by doing lighthouse investments in entirely new, repair-based approaches that treat the root causes of aging and thus overcome age-related diseases. Through the creation of successful companies, they seek to inspire scientists, investors, and the general public by demonstrating that human rejuvenation is not science fiction anymore and that the resulting therapies are affordable and uncomplicated.

Something Is Frizzling Up the Brains of Old White Guys

“This work confirms that there is a link between air pollution and how well the aging brain works,” senior study author and Columbia University researcher Andrea Baccarelli told The Guardian. “These shorter-term effects are reversible: when air pollution clears, our brain reboots and starts working back to its original level. However, multiple occurrences of these higher exposures cause permanent damage.”


Thankfully, it’s reversible.

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