Lifeboat Foundation

US biotech companies are working towards plasma therapies to tackle age-related diseases in humans.

Researchers from SENS Research Foundation, including Matthew O’Connor and Amutha Boominathan, have published a new study showing how codons play an important role in getting copies of mitochondrial genes placed in the cellular nucleus to express themselves correctly [1].

A possible solution to mitochondrial diseases

Mitochondrial disease is not a single disease; in fact, it is a group of rare and related conditions that are thought to affect perhaps 1 in 5000 people. These are caused due to mutations in the genes involved in the process of aerobic respiration, one of the main functions of our mitochondria.

Both genetically altered and naturally long-lived mammals are more resistant to toxic compounds that may cause cancer and age-associated diseases than their shorter-lived counterparts. The mechanisms by which this stress resistance occurs remain elusive. We found that longer-lived rodent species had markedly higher levels of signaling activity of the multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) and that this increase in cytoprotective signaling appeared to be due to species differences in Kelch-like ECH-Associated Protein 1 (Keap1) and β-transducin repeat-containing protein (βTrCP) regulation of Nrf2 activity. Both of these negative regulators of Nrf2-signaling activity are significantly lower in longer-lived species. By targeting the proteins that regulate Nrf2 rather than Nrf2 itself, we may be able to identify new therapies that impact aging and age-associated diseases such as cancer.

The preternaturally long-lived naked mole-rat, like other long-lived species and experimental models of extended longevity, is resistant to both endogenous (e.g., reactive oxygen species) and environmental stressors and also resists age-related diseases such as cancer, cardiovascular disease, and neurodegeneration. The mechanisms behind the universal resilience of longer-lived organisms to stress, however, remain elusive. We hypothesize that this resilience is linked to the activity of a highly conserved transcription factor, nuclear factor erythroid 2-related factor (Nrf2). Nrf2 regulates the transcription of several hundred cytoprotective molecules, including antioxidants, detoxicants, and molecular chaperones (heat shock proteins). Nrf2 itself is tightly regulated by mechanisms that either promote its activity or increase its degradation.

He remarks that we are at Kittyhawk as far as life extension goes. Most folks, including the Wright brothers, did not see a widespread use for aircraft at the time. Today in life extension the scientists working on it really do know what they are chasing.

My mission is to drastically improve your life by helping you break bad habits, build and keep new healthy habits to make you the best version of yourself.

Continue reading “Dr. Michael Fossel, President of Telocyte” »

Vlog “Posthumans” — Episode 22
Dr. Francesca Ferrando (NYU) interviews Dr. Aubrey de Grey, (SENS Research Foundation). Recorded at Princeton University (US), November 2019. Video-grapher and video-producer: Julian Boilen.

More info: http://www.theposthuman.org/vlog-posthumans.html

Continue reading “Radical Life Extension in the Posthuman Era — Dr. Aubrey de Grey interviewed by Prof. Ferrando (NYU)” »

Regenerative medicine and furthermore tissue engineering are realities for some time but well hidden from the public by msm somehow.

Dr. Stephen Badylak, Director of the Center for Pre-Clinical Tissue Engineering, McGowan Institute for Regenerative Medicine.

Continue reading “DR STEPHEN BADYLAK — Regen Med Strategies for Tissue & Organ Replacement (Long Version)” »

Do you think Xenobots is the early stage of nanobots, which could repair our body to achieve longevity escape velocity?

Scientists have created the world’s first living, self-healing robots using stem cells from frogs.

Continue reading “Scientists have built the world’s first living, self-healing robots” »

Due to the groundbreaking work in superlongevity by Dr David Sinclair and Yuancheng Ryan Lu on the Information Theory of Aging and how epigenetic therapy can be used to reverse aging, I suddenly have a compelling interest in epigenetics. Here is a recent research article that I’d recommend on.

Epigenetics can be defined as ‘the structural adaptation of chromosomal regions so as to register, signal, or perpetuate altered activity states.’ Increased transcription of key regulatory, metabolic, and myogenic genes is an early response to exercise and is important in mediating subsequent adaptations in skeletal muscle. DNA hypomethylation and histone hyperacetylation are emerging as important crucial events for increased transcription. The complex interactions between multiple epigenetic modifications and their regulation by metabolic changes and signaling events during exercise, with implications for enhanced understanding of the acute and chronic adaptations to exercise, are questions for further investigation.

Evolutionary Medicine — Linking human pathology with our past, present, and future evolutionary trajectories — ideaXme (http://radioideaxme.com/) welcomes Prof. Dr. Frank Rühli, Director of the Institute of Evolutionary Medicine, University of Zurich — #Ideaxme #EvolutionaryMedicine #Evolution #Microevolution #Paleopathology #BiologicalAnthropology #ComparativeAnatomy #Mummies #Mummy #Hypercholesterinemia #Diabetes #DrugAddiction #Health #Wellness #Regeneration #Longevity #Aging #IraPastor #Bioquark #Regenerage

Ira Pastor, ideaXme exponential health ambassador, interviews Professor Dr. Frank Rühli, Director of the Institute of Evolutionary Medicine and on the Medical Faculty of University of Zurich, and Founding Director, Chair, Full Professor of Evolutionary Medicine.

Continue reading “The Health Past Of Mummies: Evolutionary Medicine Insights For Human Diseases Now” »