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Category: life extension – Page 331

Rejuvenating Mouse Brains With Ketamine or Flickering Light

Possibilities.

Summary: Ketamine and exposure to 60-hertz flickering light show promise as a potentially new, non-invasive therapy to help rejuvenate the aging brain.

Source: IST Austria

Can you remember the smell of flowers in your grandmother’s garden or the tune your grandpa always used to whistle? Some childhood memories are seemingly ingrained into your brain. In fact, there are critical periods in which the brain learns and saves profound cognitive routines and memories. The structure responsible for saving them is called the perineuronal net.

This extracellular structure envelops certain neurons, thereby stabilizes existing connections – the synapses – between them and prevents new ones from forming. But what if we could remove the perineuronal net and restore the adaptability of a young brain? The neuroscientist Sandra Siegert and her research group at IST Austria now published two promising techniques to do so.

11-Year-Old Gets Physics Degree, Says He’ll Use It to Attain Technological Immortality

It’s an astonishing achievement — and in an eyebrow-raising twist, Simons says he plans to live forever, by turning himself into a cyborg.

It sounds like Simons has thought out his plan.

“This is the first puzzle piece in my goal of replacing body parts with mechanical parts,” Simons told De Telegraaf, adding that his goal is “immortality.”

Longevity Panel — The Scientists working on Reversing Aging | Part 1

Long vid. Slight annotation in the comments. A few takaways I liked: We need to move to human data instead of mice. People’s attitude towards life extension should change drastically soon. There is human data among this group and have released it, will keep following it, and some to be released soon. Sinclair thinks he can start primate trials this year. And overall everyone is optimistic.

A couple of weeks ago Avi Roy, alongside Nathan Cheng & Laura Minquini, hosted the Longevity Panel discussion, which assembled some of the biggest scientists in the field currently working on reversing aging.

This discussion was intended to illuminate how they are approaching longevity and to know if we are any closer in achieving it.

The talk was split into two sections: the first being open discussion guided by questions from the hosts. The talk was then opened up to the floor, allowing audience questions. Part 1 will provide the transcript from the first section of the Longevity Panel. Enjoy!

You can check out the full transcript, with addition links on the Gowing Life website: https://www.gowinglife.com/longevity-panel-the-scientists-wo…ng-part-1/

Continue reading “Longevity Panel — The Scientists working on Reversing Aging | Part 1” | >

Could AI Keep People ‘Alive’ After Death?

Researchers and entrepreneurs are starting to ponder how AI could create versions of people after their deaths—not only as static replicas but as evolving digital entities that may steer companies or influence world events.

Experts are exploring ways artificial intelligence might confer a kind of digital immortality, preserving the personalities of the departed in virtual form and then allowing them to evolve.

Translating Blood Plasma Dilution To Humans | Drs. Irina & Mike Conboy Interrview Series Ep3

The Gist: They think they can start wider human trials soon which would last 2 years then have a product in 3 to 4 years.

In this video, Drs Irina and Mike Conboy talk how TPE, therapeutic plasma exchange is already available as an FDA approved procedure and the plans to extend the usage to include more age related diseases. We also discuss the company that they have formed IMU

Our guests today are Drs. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley. their discovery of the rejuvenating effects of young blood through parabiosis in a seminal paper published in Nature in 2005 paved the way for a thriving field of rejuvenation biology. The Conboy lab currently focuses on broad rejuvenation of tissue maintenance and repair, stem cell niche engineering, elucidating the mechanisms underlying muscle stem cell aging, directed organogenesis, and making CRISPR a therapeutic reality.

Papers mentioned in this video.
Plasma dilution improves cognition and attenuates neuroinflammation in old mice.
https://pubmed.ncbi.nlm.nih.gov/33191466/
Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin.
https://pubmed.ncbi.nlm.nih.gov/32474458/
Rejuvenation of aged progenitor cells by exposure to a young systemic environment.
https://pubmed.ncbi.nlm.nih.gov/15716955/

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Continue reading “Translating Blood Plasma Dilution To Humans | Drs. Irina & Mike Conboy Interrview Series Ep3” | >

Guardian Deletes Fake News Article on Life Extension

Did you know that life extension is impossible? I didn’t until the keen minds over at the Guardian informed me as such. Fortunately before I decided to give up my career in regenerative medicine I decided to look into exactly how the Guardian came to such a revelation. What I discovered was so earth shattering that it rocked my very understanding of the world, and made me question everything I thought I knew. That realisation was that, despite their consistent insistence to the contrary, the media lies, a lot.

Ok maybe this was not as shocking as I made it out to be, in fact it’s pretty widely known by now that the media is generally no stranger to the odd lie here and there. If you are not familiar with the story allow me to give you a recap. A recent study was conducted in order to find out if human lifespans have actually increased due to advanced in medicine. To do this, scientists used statistical models to remove non-age related causes of death from historical records (such as murder, death in child birth, plague etc) in order to determine what the uninterrupted human lifespan is, and if it has increased over time. What was found is that our medical science is yet to fundamentally extend human lifespan. This comes as no surprise to anyone in the field of longevity research as we know full well that none of our current medical treatments address causes of ageing. What this study does not conclude however is that life extension is impossible.

Dr. Maria Millan, MD — President and CEO — California Institute for Regenerative Medicine (CIRM)

US$8.5 Billion In Funding — 150+ Projects

Dr. Maria Millan, MD, is the President and CEO of the California Institute for Regenerative Medicine (CIRM — https://www.cirm.ca.gov/), an organization that was created in 2004 when voters initially approved a state Proposition which allocated US$3 billion to fund this fascinating area of medicine, and which recently received an additional US$5.5 billion in renewed funding.

Dr. Millan is a physician-scientist who has devoted her career to treating and developing innovative solutions for children and adults with debilitating and life-threatening conditions.

After receiving her undergraduate degree from Duke University where she started her focus on immunology research, Dr. Millan obtained her MD degree and then went on to complete her surgical training and post-doctoral research at Harvard Medical School – Beth Israel Deaconess Medical Center.

After a transplant surgery fellowship at Stanford University School of Medicine, Dr. Millan began her academic career with a pediatric and adult transplant surgery practice. In parallel, she continued her bench research at Stanford and became associate professor and director of the Pediatric Organ Transplant Program.

Continue reading “Dr. Maria Millan, MD — President and CEO — California Institute for Regenerative Medicine (CIRM)” | >

Gene Therapy Basics

Not just the results, but the vector used. I’ll post the paper below.

In this video we cover an experiment where gene therapies to overexpress TERT and Follistatin were used in a mouse model. The mice saw a 41 and 32% increase in median life span. The study also used a novel viral vector, cytomegalovirus for the delivery. Please note that this a preprint which is not peer-reviewed yet.

Papers referred to in this newsletter.
New intranasal and injectable gene therapy for healthy life extension.
https://www.biorxiv.org/content/10.1101/2021.06.26.449305v1.full.

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Continue reading “Gene Therapy Basics” | >

Antiaging Gene Therapies Extend Lifespan of Mice

Antiaging gene therapies to overexpress TERT and Follistatin were used in a mouse model. The mice saw a 41 and 32% increase in median life span. The study also used a novel viral vector, cytomegalovirus for the delivery.

Liz Parish of Bioviva has treated herself with all of these antiaging gene therapies.

If humans experienced the same antiaging effect as the mice then humans would live to a median age of 100 with these treatments.

CI Annual General Meeting 2021

Sun, Sep 12 at 12 PM PDT.

This is an invitation to the Annual General Meeting of the Cryonics Institute & the Immortalist Society.

The Cryonics Institute, Annual General Meeting (AGM) will be held at 3:00pm to 6:30pm on Sunday, September 12th, 2021 at the Infinity Hall 16650 E. 14 Mile Rd, Fraser, MI 48026 (USA) for more information visit www.infinityhallsidebar.com or call 586−879−6157. Tours at the CI facility will be from 1:00pm to 2:30pm 24355 Sorrentino Court, Clinton Township, (Michigan) 48035 (USA).

The AGM of the Immortalist Society will be held after the CI AGM on the same day at the same location. The two meetings generally last most of the afternoon. A buffet dinner & social follow. The CI facility will be open to guests and visitors two hours before the meeting begins.

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