CRISPR/Cas9 treatment allowed mice to live 25% longer and be physically stronger. Biologists see these results being relatively easy to reproduce on humans in a clinical setting.
Category: life extension – Page 325
Dr. Ann Aerts, MD — Novartis Foundation — Transforming The Health Of Low-Income Populations Globally
Dr. Ann Aerts MD, Head of the Novartis Foundation and Member of the US National Academies of Medicine Commission on Healthy Longevity.
Dr. Ann Aerts, M.D. is Head of the Novartis Foundation, an organization committed to transforming the health of low-income populations, by leveraging the power of data, digital technology and artificial intelligence (AI) to re-imagine health and care around the world.
Dr. Aerts holds a Degree in Medicine, a Masters in Public Health from the University of Leuven, Belgium, and a Degree in Tropical Medicine from the Institute of Tropical Medicine in Antwerp, Belgium.
Dr. Aerts is passionate about improving population health through data, digital health and AI, chairs the Broadband Commission for Sustainable Development Working Group on Digital and AI in Health and is a member of the International Advisory Board of the Commonwealth Centre for Digital Health.
In 2018, Dr. Aerts served as a member of the US National Academies of Science Engineering and Medicine Committee on Improving the Quality of Health Care Globally and sits on the US National Academies of Medicine Commission on Healthy Longevity. Dr. Aerts has authored numerous publications on digital health, innovative approaches and multi-sector partnerships to address global health challenges.
How Scientists Reversed Aging, And What It Means For You
By blocking a receptor in macrophages, researchers were able to reverse aging in mice.
There are many suggested causes of old age. Telomere shortening, DNA damage, and depletion of stem cells are just a few of the proposed sources.
Recently, researchers found that a type of cell called a macrophage also plays a crucial role in aging. Macrophages are phagocytotic immune cells; they consume cells and other pathogens flagged by the immune system as dangerous. When macrophages need to consume a pathogen, their energy needs drastically go up.
Remember in biology when you were told that the mitochondria was the “powerhouse of the cell?” Cells produce energy through two main ways: glycolysis and oxidative phosphorylation. Both of these processes work inside the mitochondria by converting glucose into ATP, a molecule that acts cell’s “currency” on energy. Glycolysis converts glucose to ATP by degrading glucose into pyruvate. This reaction triggers the production of 2 ATP per molecule of glucose, which allows the cell can then use for other biological functions. Oxidative phosphorylation, on the other hand, is far more complicated, but also yields much more ATP. In a nutshell, it strips the electrons from hydrogen molecules so it can create an electrical gradient and produce up to 38 ATP per glucose molecule. Researchers found that as macrophages age, they tend to shut down these “metabolic pathways,” as they are called.
Reversed Age by Over 54% Study | The Theory of Aging | Dr Harold Katcher Interview Series Ep4/4
This is the FOURTH PART of the interview with Harold Katcher in Modern Healthspan YouTube channel.
Dr. Harold Katcher is a professor of Biology at the University of Maryland. He has been a pioneer in the field of cancer research, in the development of modern aspects of gene hunting and sequencing. He carries expertise in bioinformatics, chronobiology, and biotechnology. Dr. Katcher is currently working in the capacity of Chief Technical Officer at Nugenics Research exploring rejuvenation treatments in mammals.
In May 2020 there was a paper published on biorxiv about the rejuvenation of rats by over 50%. We did a review of the paper which you can find linked to above. In this interview series we talk with Dr. Harold Katcher, one of the main authors of the paper about the experiment, the steps to get validation, commercialization and how the results fit into his theories of aging.
In this video Dr. Katcher explains his theories on what causes aging, which he believes is a process that is programmed into us and is therefore malleable. I find his theories very interesting and compelling.
Dr. Katcher’s 2015 paper on the theory of aging is here:
Towards an evidence-based model of aging.
https://pubmed.ncbi.nlm.nih.gov/26054348/
The paper on plasma exchange can be found here https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.full.
Matt Kaeberlein on the biology of aging. Excerpts from an interview with Brian Kennedy
Excerpts from an enlightening interview / conversation conducted by Brian Kennedy with Matt Kaeberlein on the biology of aging.
The interview took place in November 2020 as the first one under the healthy longevity webinar series organized by Brian Kennedy from the National University of Singapure (NUS).
During the conversation, Matt Kaeberlein makes a nice description about what aging is, as well as about therapies, drugs and other interventions that, at least in animals of various kinds, manage to modulate (delay / reverse) the progress of aging.
Among other projects, Matt Kaeberlein tells us that he’s planning to conduct an evaluation of various antiaging interventions in dogs.
To watch the entire interview, which has no waste, follow the link in the description of the video.
The interview took place in November 2020 as the first one under the healthy longevity webinar series organized by Dr. Brian Kennedy from the National University of Singapure (NUS).
Michael Antonov — Formic Ventures — Taking On Huge Challenges — From VR To Longevity Biotechnology
Formic ventures — taking on huge challenges — from virtual reality technologist to longevity biotechnology investor.
Michael Antonov is the Founder and CEO of The Michael Antonov Foundation (https://antonovfoundation.org/), a charitable organization that supports biotechnology research and various causes that improve well being of people around the world, as well as Formic Ventures (https://formic.vc/index.html), an early stage high tech and biotech investment firm focused on prolonging human healthspan and empowering human creativity.
Michael is a serial entrepreneur and philanthropist passionate about taking on huge challenges that can make a difference in human lives, such as solving the problem of aging.
Prior to launching the foundation, Michael was a technology executive, most recently as the co-founder and Chief Software Architect at Oculus, acquired by Facebook, where he helped revive the virtual reality industry. Prior to that, Michael was the co-founder and CTO of Scaleform, a user interface software company, whose product is embedded into hundreds of computer, console, and mobile games around the world.
Michael is a graduate of the University of Maryland in the field of computer science and is a member of their alumni hall of fame.
Reversed Age by Over 54% Study | Steps to Availaility | Dr Harold Katcher Interivew Series Ep3
This is the THIRD PART of the interview with Harold Katcher in Modern Healthspan YouTube channel.
Dr. Harold Katcher is a professor of Biology at the University of Maryland. He has been a pioneer in the field of cancer research, in the development of modern aspects of gene hunting and sequencing. He carries expertise in bioinformatics, chronobiology, and biotechnology. Dr. Katcher is currently working in the capacity of Chief Technical Officer at Nugenics Research exploring rejuvenation treatments in mammals.
In May 2020 there was a paper published on biorxiv about the rejuvenation of rats by over 50%. We did a review of the paper which you can find linked to above. In this interview series we talk with Dr. Harold Katcher, one of the main authors of the paper about the experiment, the steps to get validation, commercialization and how the results fit into his theories of aging.
In this video we talk about the next steps towards commercialization and how the treatment that is being developed from this research will be made available. Dr. Katcher is very optimistic with a view that the treatment should be on the market within a few years.
The paper can be found here https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.full.
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Whatabout 1: The future
This is “Whatabout 1: The future by Aubrey de Grey, gerontologist” by WHAT on Vimeo, the home for high quality videos and the people who love them.
Elixir Plasma 3rd Party Verification | Dr Harold Katcher Interivew Series Ep2
This is the SECOND PART of the interview with Harold Katcher in Modern Healthspan YouTube channel.
Dr. Harold Katcher is a professor of Biology at the University of Maryland. He has been a pioneer in the field of cancer research, in the development of modern aspects of gene hunting and sequencing. He carries expertise in bioinformatics, chronobiology, and biotechnology. Dr. Katcher is currently working in the capacity of Chief Technical Officer at Nugenics Research exploring rejuvenation treatments in mammals.
In May 2020 there was a paper published on biorxiv about the rejuvenation of rats by over 50%. We did a review of the paper which you can find linked to above. In this interview series we talk with Dr. Harold Katcher, one of the main authors of the paper about the experiment, the steps to get validation, commercialization and how the results fit into his theories of aging.
In this video we talk about how the results from the experiment will be validated in two third party labs. One of which will use Rhesus monkeys and the other, under Dr. Greg Fahy, will use dogs.
The paper can be found here https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.full.
If you would like to support our channel, we’d love a coffee…thank you! https://www.buymeacoffee.com/mhealthspan.
Cold Showers Pros And Cons — And Other Cold Therapies. The Science
Did you know, getting a bit cold from time to time can help you get fitter, live longer, reduce pain and discomfort and help you concentrate and feel great?
Whether it is cold showers, ice baths, swimming in open water or trying out cryotherapy, enduring the cold is becoming increasingly popular as a way to hack your body as an aid to longevity and a good health span.
And for a good reason.
It effects metabolism, heart rate, blood pressure and many biomarkers.
It improves pain tolerance and levels, your mood and energy levels.
It effects mitochondrial biogenesis and brown fat stores, even beiging previously white adipose tissue.
In fact, there are hardly any systems left untouched.
But it does have side effects as well, especially for those who have health issues, but they also have the most to gain.
If you want to get more detail then check out this video where I go into more depth looking at the subject and discuss the studies that have been done to assess the effects.
Have a great day.
In Cold Showers Pros And Cons — And Other Cold Therapies, I will be looking at the good, and the bad, when it comes to embracing cold therapies from cold water swimming and ice baths, through to cold showers and cryotherapy.
What are they all about?
How do they work?
Do they even work?
Are they dangerous?
If you want to know the answer to these and more then just watch this video.
And after yo have finished, why not try this one about the benefits of saunas… https://youtu.be/dTwOMjWnzhg As always the studies that I mentioned are linked here… ECT overview https://www.mayoclinic.org/tests-proc… view of treatment Electroconvulsive Therapy for Depression: A Review of the Quality of ECT versus Sham ECT Trials and Meta-Analyses https://connect.springerpub.com/conte… Scientific Evidence-Based Effects of Hydrotherapy on Various Systems of the Body https://www.ncbi.nlm.nih.gov/pmc/arti… Plasma Renin study https://www.ncbi.nlm.nih.gov/pmc/arti… Effects of long-term whole-body cold exposures on plasma concentrations of ACTH, beta-endorphin, cortisol, catecholamines and cytokines https://pubmed.ncbi.nlm.nih.gov/18382… Human physiological responses to immersion into water of different temperatures https://link.springer.com/article/10… The effects of exercise and cold exposure on mitochondrial biogenesis in skeletal muscle and white adipose tissue https://www.ncbi.nlm.nih.gov/pmc/arti… Cold and Exercise: Therapeutic Tools to Activate Brown Adipose Tissue and Combat Obesity https://www.ncbi.nlm.nih.gov/pmc/arti… Cold-induced vasoconstriction may persist long after cooling ends: an evaluation of multiple cryotherapy units https://www.ncbi.nlm.nih.gov/pmc/arti…