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Category: life extension – Page 306

Human Enhancement & Personal Performance Hacking with Matt Ward of “The Disruptors”

We explore human enhancement and personal performance hacking with Matt Ward (@mattwardio), host of The Disruptors podcast, startup investor, adviser, and business innovation consultant. Matt and I thought it would be fun to do two episodes, one here on MIND & MACHINE and the other on The Disruptors, where we explore what we’ve learned, the ideas we’ve formed and our takeaways across all these different fields that we cover.

So with this episode here on MIND & MACHINE, we focus on human enhancement — technologies that are extending lifespan and enhancing human capability. Then we get into what Matt and I are doing currently to maximize our own performance capabilities — our ability to think more clearly, to live more energetic vibrant lives… which is all heavily informed by all these amazing guests across these different fields that we explore.

In the other part of this discussion, on The Disruptors, we look at another set of subjects from space to AI to Augmented and Virtual reality. So I encourage you to check that out as well at The Disruptors… For the other part of the Conversation on The Disruptors: https://is.gd/mv1Vez https://youtu.be/PtpwgTr4GSU __________ MIND & MACHINE features interviews by August Bradley with bold thinkers and leaders in transformational technologies. Subscribe to the MIND & MACHINE newsletter: https://www.mindandmachine.io/newsletter MIND & MACHINE Website: https://www.MindAndMachine.io Subscribe to the podcast on: iTunes: https://www.mindandmachine.io/itunes Android or Other Apps: https://www.mindandmachine.io/android Show Host August Bradley on Twitter: https://twitter.com/augustbradley _____________________________

For the other part of the Conversation on The Disruptors:
https://is.gd/mv1Vez.

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MIND & MACHINE features interviews by August Bradley with bold thinkers and leaders in transformational technologies.

Multivitamins, but not cocoa, bound for slower brain aging

Taking a daily multivitamin for 3 years is associated with a 60% slower cognitive aging, with the effects particularly pronounced in patients with cardiovascular (CVD) disease, new research suggests.

In addition to testing the effect of a daily multivitamin on cognition, the COSMOS-Mind study also examined the effect of cocoa flavonols, but showed no beneficial effect.

The results “may have important public health implications, particularly for brain health, given the availability of multivitamins and minerals and their low cost and safety,” said research researcher Laura D. Baker, PhD, professor, Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.

David Sinclair on partial cellular reprograming and rejuvenation (with S/T in Spanish)

One-minute-long excerpt of the intervention of Professor David Sinclair during an event organized by the SALT Fund, that took place in October.

In this excerpt, Professor Sinclair talks about the work done in his Lab at Harvard University on partial cellular reprogramming and rejuvenation.

The panel counted with the participation of three antiaging and longevity experts:
* Dr. David Sinclair, Professor of Genetics, Harvard Medical School.
* Dr. Eric Verdin, Chief Executive Officer & President, Buck Institute for Research on Aging.
* Dr. Jennifer Garrison, Assistant Professor, Buck Institute for Research on Aging.

The moderator was Dr. Dina Radenkovic, Partner, The SALT Fund.

In the description of the video is the link to the full event.

Dr Corinne Leach, Ph.D. — Gerontology, Digital Health, Behavioral Science — American Cancer Society

Innovation At The Intersection Of Cancer & Aging, Via Digital Health & Behavioral Sciences — Dr. Corinne Leach, Ph.D. American Cancer Society

Dr. Corinne Leach, PhD, MPH, MS, is a gerontologist, digital health strategist, and behavioral scientist, who serves as the Senior Principal Scientist, Behavioral Research, at the American Cancer Society (https://www.cancer.org/).

Dr. Leach, leads survivorship research on behalf of the Population Sciences group, serving as the Principal Investigator of the American Cancer Society (ACS) survivorship cohorts, and as the ACS-lead for the ACS-National Cancer Institute online self-management platform, Springboard Beyond Cancer, a novel eHealth tool that empowers cancer survivors to better manage their cancer-related symptoms, live healthier, and improve their communication skills about cancer (as well as other health conditions), during and after treatment.

Dr. Leach’s cancer survivorship research focuses in the areas of aging, cancer-related symptom assessment, and chronic disease self-management, and her research aims to improve the understanding of: behavioral factors that contribute to healthy aging and the best way to promote them, the unique experiences of older cancer survivors, such as physical late effects and psychosocial issues, and ways to improve survivors’ self-management of cancer-related issues.

Dr. Leach also studies accelerated aging after a cancer diagnosis, including the accumulation of multiple chronic conditions after a cancer diagnosis, and she evaluates the benefits of health behavior interventions, such as chronic disease self-management.

Continue reading “Dr Corinne Leach, Ph.D. — Gerontology, Digital Health, Behavioral Science — American Cancer Society” | >

Becoming Immortal for 10,000$? — Upload Your Mind THIS DECADE!

Becoming Immortal through Mind Uploading sounds like something that’ll only be possible around the 2100’s. But amazingly, a group of scientists at Nectome are working on giving us the ability to live forever inside of a computer simulation by the end of this decade for around 10000$.

Ray Kurzweil, director of engineering at Google, has long predicted that people will be able to upload their entire brains to computers and become digitally immortal by 2045. Kurzweil made this claim for many years, e.g. during his speech in 2013 at the Global Futures 2045 International Congress in New York, which claims to subscribe to a similar set of beliefs. Mind uploading has also been advocated by a number of researchers in neuroscience and artificial intelligence, such as the late Marvin Minsky.
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TIMESTAMPS:
00:00 The Future is near.
01:46 How this procedure works.
03:31 The development of this technology.
04:24 Is this actually possible to achieve?
06:58 The ethical concerns.
07:40 Last Words.
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#longevity #minduploading #bci

Anti-aging research uncovers new role for telomeres

Aging affects everybody, so it’s easy to understand why so much scientific attention is focused on studying it. Scientists in Canada now claim to have found that telomeres play a different role in cellular aging than previously thought.

One of the main points of interest in anti-aging biology are what’s known as telomeres. These are sections of “junk” DNA that form caps on the ends of chromosomes, protecting important genetic information from damage when a cell divides. But a piece of the telomere is eroded away with each cell division, and when it gets too short the cell stops dividing entirely, entering a dormant state known as senescence. The build-up of these senescent cells contributes to a range of symptoms we associate with aging, such as frailty and age-related diseases.

The implication of this model is that telomeres take on a pre-emptive protection role – they signal to cells to stop dividing as soon as one telomere wears out. But there is evidence to suggest that cell division can continue with as many as five dysfunctional telomeres.

Cryonics Clinics: Where People Sleep and Wake Up in the Future

Cryogenically frozen dead people are held preserved in a clinic at Scottsdale, Arizona in the hope that maybe someday science would be advanced enough to bring them back to life. This unique cryonics clinic is run by Alcor Life Extension Foundation, and surprisingly, many people, including some famous personalities like PayPal co-founder Peter Theil, are actually spending hundreds of thousands of dollars to have their bodies preserved here after death.

The idea of waking up in the future sounds like a great plot for a sci-fi movie or a novel but through cryonics 0 organizations like Alcor are trying to do the same in reality. Max Moore, a futurist and the former CEO of Alcor, believes that people can be rescued from death. “Our view is that when we call someone dead it’s a bit of an arbitrary line. In fact they are in need of a rescue,” he said in an interview. What’s perhaps more surprising is that Alcor is not the only cryonics clinic preserving dead bodies for revival in the future.

Dr. Judith Campisi, Ph.D. — Professor of Biogerontology — Buck Institute for Research on Aging

Discussing The Future Of “Seno-Therapeutic” Development — Dr. Judith Campisi, PhD, Professor of Biogerontology, Buck Institute for Research on Aging.

Dr. Judith Campisi, PhD (https://www.buckinstitute.org/lab/campisi-lab/) is a biochemist, cell biologist, and Professor of Biogerontology at the Buck Institute for Research on Aging.

Dr. Campisi received a PhD in biochemistry from the State University of New York at Stony Brook and completed her postdoctoral training in cell cycle regulation at the Dana-Farber Cancer Institute and Harvard Medical School. As an assistant and associate professor at the Boston University Medical School, she studied the role of cellular senescence in suppressing cancer and soon became convinced that senescent cells also contributed to aging. She joined the Lawrence Berkeley National Laboratory as a senior scientist in 1991 working with Dr. Mina Bissell. In 2,002 she started a second laboratory at the Buck Institute. At both institutions, Dr. Campisi established a broad program to understand the relationship between aging and age-related disease, with an emphasis on the interface between cancer and aging.

Dr. Campisi is a member of the National Academy of Sciences and a fellow of the American Association for the Advancement of Science.

Dr. Campisi has received numerous awards for her research, including two MERIT awards from the National Institute on Aging and awards from the AlliedSignal Corporation, Gerontological Society of America, and American Federation for Aging Research. She is a recipient of the Longevity prize from the IPSEN Foundation, the Bennett Cohen award from the University of Michigan, and the Schober award from Halle University, and she is the first recipient of the international Olav Thon Foundation prize in Natural Sciences and Medicine. Dr. Campisi currently serves on advisory committees for the Alliance for Aging Research, Progeria Research Foundation, and NIA’s Intervention Testing Program. She is also an editorial board member for more than a dozen peer-reviewed journals. Dr. Campisi is a scientific founder of Unity Biotechnology, a California-based company focused on developing senolytic therapies for age-related pathologies. She has served on the scientific advisory boards of the Geron Corporation, Sierra BioScience, and Sangamo Biosciences.

Continue reading “Dr. Judith Campisi, Ph.D. — Professor of Biogerontology — Buck Institute for Research on Aging” | >

Landmark study points to source of rapid aging, chronic inflammation in people living with HIV

Shokrollah Elahi led a new study showing that short-lived white blood cells called neutrophils play a role in impaired T cell functions and counts in people with HIV, as well as the chronic inflammation that is common with the virus. (Photo: Najmeh Bozorgmehr)

In a groundbreaking study of people living with HIV, University of Alberta researchers found that elusive white blood cells called neutrophils play a role in impaired T cell functions and counts, as well as the associated chronic inflammation that is common with the virus.

Neutrophils are a foundational part of the body’s immune system and the most abundant type of white blood cell, making up about 60 to 80 per cent of circulating immune cells in the blood. However, unlike other types of white blood cells, neutrophils are extremely short-lived and cannot be frozen and thawed like other immune cells, making them extremely difficult to examine, said study lead Shokrollah Elahi.

“Neutrophils live for hours to a day or two maximum,” Elahi said. “The body produces a lot of neutrophils, and they do their job and then they die and have to be regenerated in the bone marrow. But despite the fact that neutrophils are the most abundant white blood cells in the blood circulation, their role in the context of HIV has not been very well defined.”

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