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Category: life extension – Page 299

Sirtuin 6 : Summary Of Key Points of Professor Cohen Interview | Modern Healthspan

There is a SIRT6 activator on the market but it is very expensive at a few hundred dollars.

We have had requests for a summary of the interview with Prof Cohen. This video is a summary of the key points from the interviews. As I note in the introduction, this is my interpretation of what Prof Cohen said, please check the original interviews if you have any questions. And please do feel free to let me know if you think I got something wrong!

Professor Haim Cohen is the director of the Sagol Healthy Human Longevity Center at Bar-Ilan University where he focuses much of his research on the SIRT6 protein. In May 2021 he and his team published a paper showing a 30% increase in lifespan in a mouse model by over expressing SIRT6.

Prof Cohen’s page at the university.
https://life-sciences.biu.ac.il/en/node/641
Prof Cohen’s Lab.
https://www.haimcohenlab.com/

Prof Cohen’s Paper on Sirt6 is here.

Continue reading “Sirtuin 6 : Summary Of Key Points of Professor Cohen Interview | Modern Healthspan” | >

Longevity Research is an Economic Necessity

It is vital to recognize the immediate economic importance of i nvesting in longevity and healthy-aging sciences.

Aging itself is a complex series of at least 300 biological processes involving more than 10% of our genetic makeup. It follows that methods to combat these effects must be a combination of sciences, from biotech to biophysics and pharmaceuticals. There is no single “silver bullet” solution.

Aging, along with the physical and mental decay that accompanies it, is still widely regarded as a natural and inevitable thing. It is not, it is a degenerative disease in which the physical integrity and structure of our cells decay each time they divide to replace old ones or as part of any healing process.

Blood Test Analysis: Italian Centenarians

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Biomarker timestamps:
Glucose 1:37
HDL 2:43
Triglycerides 4:10
RBCs, Hemoglobin 5:29
Platelets 7:16
Uric Acid 8:37
AST, ALT 11:04
Total Cholesterol 13:55
WBCs 15:47
Total Protein, Albumin, Globulin 17:38
Creatinine 21:27
BUN 22:35

Papers referenced in the video:
Laboratory parameters in centenarians of Italian ancestry.
https://pubmed.ncbi.nlm.nih.gov/17681733/

Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians.
https://pubmed.ncbi.nlm.nih.gov/31908434/

Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study.
https://pubmed.ncbi.nlm.nih.gov/32623847/

High-density lipoprotein cholesterol and all-cause mortality by sex and age: a prospective cohort study among 15.8 million adults.

Continue reading “Blood Test Analysis: Italian Centenarians” | >

2022 Conference

This year, the Alcor Life Extension Foundation is celebrating its 50th year. To mark the occasion, we are holding a conference on June 3–5, 2022, at the Scottsdale Resort in Scottsdale, Arizona.

The conference itself will be Alcor’s first major in-person gathering in seven years, so we’re going to “go big.” We expect members, prospective members, and others interested in life extension and the far future to turn out enthusiastically. We hope not only that our attendees will enjoy hearing from and interacting with you, but also that you may find the experience enjoyable. There is no organization quite like Alcor, after all, and very few opportunities to explore cryonics and its implications for society now and in the far future.

Dr. Pat Verduin, PhD — Chief Technology Officer — Colgate-Palmolive — Reimagining A Healthier Future

Reimagining A Healthier Future for All — Dr. Pat Verduin PhD, Chief Technology Officer, Colgate, discussing the microbiome, skin and oral care, and healthy aging from a CPG perspective.

Dr. Patricia Verduin, PhD, (https://www.colgatepalmolive.com/en-us/snippet/2021/circle-c…ia-verduin) is Chief Technology Officer for the Colgate-Palmolive Company where she provides leadership for product innovation, clinical science and long-term research and development across their Global Technology Centers’ Research & Development pipeline.

Dr. Verduin joined Colgate Palmolive in 2007 as Vice President, Global R&D. Previously she served as Vice President, Scientific Affairs, for the Grocery Manufacturers Association, and from 2000 to 2006, she held the position of Vice President, Research & Development, at ConAgra Foods.

Dr. Verduin started her career with 17 years at Nabisco, serving in multiple roles, including plant manager and scientist. She earned her undergraduate degree from the University of Delaware, holds an MBA from Fairleigh Dickinson University and a PhD in Food Science from Rutgers University.

Colgate-Palmolive Company (https://www.colgatepalmolive.com/) is an American multinational consumer products company specializing in the production, distribution and provision of household, health care, personal care and veterinary products, with a mission of re-imagining a healthier future for all people, their pets and our planet.

Continue reading “Dr. Pat Verduin, PhD — Chief Technology Officer — Colgate-Palmolive — Reimagining A Healthier Future” | >

The long and gruesome history of people trying to live forever

Estimates put this industry’s worth at a staggering $610 billion by 2025. 😳

The Renaissance philosopher Montaigne quipped that “death has us by the scruff of the neck at every moment.” He could have added: until, finally, it strangles us. But what if we knew how to escape death’s chokehold? What if we could avoid death and live forever?

Immortality might seem like the stuff of science fiction, yet it’s increasingly becoming the focus of real science. In 2013, Google launched Calico, a biotech firm whose objective is to “solve” death. PayPal co-founder Peter Thiel, meanwhile, has pledged to “fight” death. And last year, it was reported Amazon chairman Jeff Bezos had invested in Altos Labs, a company that plans to “rejuvenate” cells in order to “reverse disease.” (Bezos owns The Washington Post.)

Subscribe to The Post Most newsletter for the most important and interesting stories from The Washington Post.

Dr Katcher’s E5 Experiment May 2022 Update | Review

Not an amazing update. All female rats are not getting the results the previous group of males got. To my knowledge human trials are still actively being set up for late this year.

In this video we report on the May 2022 update from Dr. Katcher’s experiment with E5, where he is testing to see how long the rats will stay alive if they are given an E5 injection every 90 days.

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Links for this video.
Sign up for the newsletter from NTZ Publishing here:
https://www.ntzplural.com/newsletter.
Reversing age: dual species measurement of epigenetic age with a single clock.
https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.full.
The entry on Dr Josh Mitteldorf’s Aging Matters blog.

Age Reduction Breakthrough

Our discussion of original paper.
https://youtu.be/DokfEzQt_wk.
Playlist for Dr. Katcher August 2021 Interview Series.

Playlist 1 for Dr. Katcher.
https://www.youtube.com/playlist?list=PLkfzM7KJv6vaIQZ_n3WS6FHTpBtfS2lzw.

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Continue reading “Dr Katcher’s E5 Experiment May 2022 Update | Review” | >

Methionine Restriction Extends Lifespan-What’s Optimal For Protein Intake? n=1 Analysis

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Papers referenced in the video:
Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age.
https://pubmed.ncbi.nlm.nih.gov/19414512/

Low methionine ingestion by rats extends life span.
https://pubmed.ncbi.nlm.nih.gov/8429371/

Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study.
https://pubmed.ncbi.nlm.nih.gov/32623847/

Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study.
https://pubmed.ncbi.nlm.nih.gov/7474221/

Predicting Age by Mining Electronic Medical Records with Deep Learning Characterizes Differences between Chronological and Physiological Age.

Continue reading “Methionine Restriction Extends Lifespan-What’s Optimal For Protein Intake? n=1 Analysis” | >

YouthBio CEO: The time is right to develop epigenetic reprogramming therapies

Earlier this month, we brought you the news that epigenetic reprogramming startup YouthBio Therapeutics had emerged from stealth. The company shed some light on its plans to develop epigenetic reprogramming therapies for age-related diseases by rejuvenating certain cells in our bodies. YouthBio aims to achieve this rejuvenation by developing gene therapies that enable partial cellular reprogramming – an area of longevity science that is now attracting significant commercial interest.

Longevity. Technology: Cellular reprogramming refers to the process of returning adult cells to a “pluripotent” state: blank, embryonic-like cells that can become any cell in the body. This reprogramming can be achieved using techniques based on the discovery of Yamanaka factors.

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