Lifeboat Foundation

David Sinclair wants to slow down and ultimately reverse aging. Sinclair sees aging as a disease and he is convinced aging is caused by epigenetic changes, abnormalities that occur when the body’s cells process extra or missing pieces of DNA. This results in the loss of the information that keeps our cells healthy. This information also tells the cells which genes to read. David Sinclair’s book: “Lifespan, why we age and why we don’t have to”, he describes the results of his research, theories and scientific philosophy as well as the potential consequences of the significant progress in genetic technologies.

At present, researchers are only just beginning to understand the biological basis of aging even in relatively simple and short-lived organisms such as yeast. Sinclair however, makes a convincing argument for why the life-extension technologies will eventually offer possibilities of life prolongation using genetic engineering.

Continue reading “Harvard Professor Wants to Slow Down & Reverse Aging: David Sinclair’s Approach For a Longer Life” »

11 epigenetic clocks have been published since 2011, but which is best for predicting aging and age-related disease? In this video, I present findings from a recent publication, “Underlying features of epigenetic aging clocks in vitro and in vivo”, that compared data for 11 epigenetic clocks, and derived a new epigenetic clock, the meta-clock.

In order to slow aging, it’s important to know how circulating biomarkers change during aging, and how these biomarkers are associated with risk of death for all causes. In this video, I discuss blood test data for the oldest old, including centenarians (100 — 104y), semi-centenarians (105 — 109y), and super-centenarians (110y+).

Lil bits of info on DNA methylation, clocks.

Breakthrough advances in medicine and better nutrition have dramatically improved the longevity of the average human over the past two centuries. But that’s not to say that some couldn’t go on to live a long life even before the advent of modern medicine. As long as they were spared by disease, wars, and other risks that can bring an untimely death, humans could live to see their 70s, 80s, and even reach 100 years old as far back as ancient Rome.

The longevity of humans is somewhat exceptional among primates. Chimpanzees, our closest living relatives, rarely make it past age 50, despite them sharing over 99% of our DNA. In a new study, researchers think they’ve found our secret: chemical changes along our genome that occurred around 7–8 million years ago when our ancestors branched away from the lineage of chimps.

Continue reading “Humans live much longer than chimps due to a slower epigenetic ‘clock’” »

WEDNESDAY, Sept. 23, 2020 (HealthDay News) — A common type 2 diabetes drug called metformin may have an unexpected, but positive, side effect: New research suggests that people taking the drug appear to have significantly slower declines in thinking and memory as they age.

“Our six-year study of older Australians with type 2 diabetes has uncovered a link between metformin use and slower cognitive [mental] decline and lower dementia rates,” said study author Dr. Katherine Samaras. She’s the leader of the healthy aging research theme at the Garvan Institute of Medical Research in New South Wales, Australia.

“The findings provide new hope for a means of reducing the risk of dementia in individuals with type 2 diabetes, and potentially those without diabetes,” Samaras said.

Targeting Mechanisms of Aging Across Species — I am joined on this episode of ideaXme by Dr. Matt Kaeberlein, Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences, University of Washington, to discuss his research focus on cross-species mechanisms of aging, in order to facilitate interventions that extend healthspan and improve quality of life — #Ideaxme #Health #Wellness #Longevity #Aging #LifeExtension #Rapamycin #MTor #CElegans #ExtracellularVesicles #Geroscience #GenomicInstability #AlzheimersDisease #Neurodegeneration #Parkinsons #MitochondrialDysfunction #OralHealth #SystemsBiology #DogAgingProject #Science #Transhumanism #Innovation #Immortality #IraPastor #Bioquark #Regenerage The Dog Aging Project.

Ira Pastor, idea me life sciences ambassador and founder of Bioquark, interviews Dr. Matt Kaeberlein, Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences at the University of Washington.

Continue reading “Targeting the Mechanisms of Aging Across Species” »

Boxing, Business, and Well-Being — I am joined on this episode of ideaXme by George Foreman III; entrepreneur, professional boxer, trainer, coach, son / business partner of former two-time heavyweight boxing champion George Foreman, and founder of EverybodyFights, a rapidly expanding chain of high-end, state-of-the-art boxing and fitness gyms — #Ideaxme #Health #Wellness #Boxing #GeorgeForeman #Fitness #Gyms #Nutrition #Longevity #Aging #Healthspan #Lifespan #LifeExtension #Business #Entrepreneurship #Innovation #Startup #IraPastor #Bioquark #Regenerage

Ira Pastor, ideaXme life sciences ambassador, interviews George “Monk” Foreman III; entrepreneur, professional boxer, trainer, coach, and Founder of Everybody Fights.

Continue reading “Boxer George ‘Monk’ Foreman III talks of Compassion and Everybody Fights!” »

We all want to know how to live longer, but is a prolonged life a healthy, happy one? One Vogue writer looks at the science that says it might be possible.

Short excerpt of a recent interview with Dr. David Sinclair published in the Youtube channel “Think Inc.”

Short excerpt of an interview with Dr. David Sinclair published in the Youtube channel “Think Inc.“
During the interview, Dr. Sinclair referres to the possibility of turning back the biological aging clock of the entire human body, through partial cellular reprograming in the not so distant future.

Continue reading “David Sinclair talks about human rejuvenation (Excerpt with S/T in Spanish)” »