“Harms in early life can take many forms, and can lead to health consequences many years down the road. What our study shows is that these consequences manifest as perturbations to multiple biological systems, which can be measured from biomarkers in blood.”…

Individuals exposed to adverse childhood experiences tend to be biologically older than their counterparts, according to new research published in the scientific journal Psychoneuroendocrinology.

Adverse childhood experiences refer to a set of potentially traumatic events that occur before adulthood. These experiences include various forms of abuse and neglect, witnessing intimate partner violence, parental death or serious illness, parental divorce or separation, and psychiatric illness of a family member. Biological aging, on the other hand, refers to the accumulation of damage and loss of function to cells, tissues and organs.

Previous research has found that people exposed to adverse childhood experiences are more likely to suffer from chronic diseases and have a shorter lifespan. The authors of the new study were interested in whether accelerated biological aging could help explain the relationship between adverse childhood experiences and poor health outcomes later in life.

A new King’s-led study, published in the Proceedings of the National Academy of Sciences, has found that a single factor (a protein coding gene known as Sox8) can make non-ear cells adopt ear character during embryo development. The findings not only demonstrate how cell fate decisions are regulated in the embryo but may also inform reprogramming and regenerative strategies for the ear developmental malformations.

Responsible for the sense of hearing and balance, the inner ear is critically important for communication with the environment. In humans, developmental malformations of the ear have life-long consequences, while age-related hearing defects affect a large proportion of the population. Currently, there are no therapies that involve biological approaches—only hearing aids or cochlear implants, as how the ear normally develops is not fully understood and many of the controlling factors are poorly characterized.

Researchers from the Faculty of Dentistry, Oral and Craniofacial Sciences at King’s, in collaboration with colleagues from the Francis Crick Institute, explored the earliest steps in ear development to determine what causes cells to become ear cells, and what makes them different from cells which form other sense organs.

Is longevity desirable? Review of biological immortality in storytelling.

And what the prospects are to achieve it in the near future.

The quest for longer lifespan and healthspan.

Since the dawn of human civilization we were inspired by the quest for immortality and eternal youth.

But now, with new advances in medical science, this quest is on the verge of becoming a reality.