Bacteria that cause leprosy are shown to safely grow and regenerate the liver, in animal experiments.
Category: life extension – Page 242
Potential Interventions For HUMAN LONGEVITY, CaAKG Is More Effective for People w/Accelerating Aging
This is primarily about Rejuvant or AKG trials. When they first reported an 8 year age difference I did not truly believe it as that would mean I could take it, de-age, then age a bit, then just take it again. The tests however are ongoing and will feature people who are biologically older than their calendar age. There is also mention of 110 drugs/supplements that do “something” to mice. That would be quite a stack to take.
Dr Brian Kennedy presents potential interventions for extend our healthspan. Among them, Rejuvant – a CaAKG supplement which contain calcium + alpha-ketoglutarate shows better response for people who has biological age older than chronological age.
The first human trial of Rejuvant to reverse human biological age by 8 years in 7 month.
Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660611/
Dr. Brian Kennedy is internationally recognized for his research in the basic biology of aging and as a visionary committed to translating research discoveries into new ways of delaying, detecting, and preventing human aging and associated diseases. He is a Professor in the Departments of Biochemistry and Physiology at National University Singapore and Director of the Centre for Healthy Ageing in the National University Health System. From 2010 to 2016 he was the President and CEO of the Buck Institute for Research on Aging. Currently, he remains as a Professor at the Institute. Dr. Kennedy also has an adjunct appointment at the USC Davis School of Gerontology. Dr. Kennedy is also actively involved Biotechnology companies, serving in consulting and Board capacities, as well as Scientific Director of Affirmativ Health. Dr. Kennedy also serves as a Co-Editor-In-Chief at Aging Cell.
Dr. Michael Hufford, PhD — Advancing Novel Therapeutic Interventions For Unmet Medical Needs
Advancing Novel Therapeutic Interventions For Unmet Medical Needs — Dr. Michael Hufford, Ph.D., Co-Founder and CEO, LyGenesis; Interim CEO, Morphoceuticals; Scientific Advisor, Juvenescence.
Dr. Michael Hufford, Ph.D. is the Co-Founder and the Chief Executive Officer of LyGenesis (https://www.lygenesis.com/), a clinical-stage cell therapy company that transforms patient’s lymph nodes into bioreactors capable of growing functioning ectopic organs. He also serves as the Interim CEO of Morphoceuticals (https://www.morphoceuticals.com/) a company focused on modifying electric potentials in cells and tissues for a variety of applications in regenerative medicine, from improving amputation stump health and limb regeneration, to organogenesis, to creating a bioelectric atlas where numerous disease indications may be corrected.
Dr. Hufford also serves as a scientific advisor to Juvenescence (https://juvlabs.com/) a biotech holding company that develops therapies and products to modify aging and help people live longer.
An entrepreneur and drug developer, Dr. Hufford has over 20 years of experience in the development and FDA regulatory approval of small molecules (Cypress Bioscience), biologics (Amylin Pharmaceuticals), as well as drug delivery technologies (e-Nicotine Technology). He has designed and executed clinical trials and drug development programs across a wide variety of therapeutic areas, from orphan metabolic diseases to psychiatric and oncology indications. His experience in-and out-licensing pre-clinical and clinical stage assets, executing corporate partnering deals, and in investor relations, has helped him to raise public, private, and angel-back financing for his companies. His philanthropic work includes co-founding and serving as the CEO of Harm Reduction Therapeutics, Inc. (https://www.harmreductiontherapeutics.org/), a nonprofit pharmaceutical company developing low-cost over-the-counter intra-nasal naloxone in the US to help prevent opioid overdose deaths.
Dr. Hufford earned his undergraduate degree with distinction from Purdue University, and his master’s and doctoral degrees in Clinical Psychology from the University of Pittsburgh, before completing a Research and Clinical Fellowship in the Department of Psychiatry at Harvard Medical School. He is an award-winning lecturer, and the author of more than 100 scientific publications, presentations, and OpEds, with multiple issued and pending patents.
Alex Zhavoronkov: Live Long and Prosper
The maniacally focused founder of Insilico Medicine is going all in on AI to discover new medicines and extend lifespan.
But researchers are now using artificial intelligence to accelerate parts of that process by orders of magnitude. The same kind of technology that recognizes your face or autocompletes your emails can potentially add years to your life, experts say.
The Cryonics Institute Newsletter Issue 03
2022 https://cryonics.org/wp-content/uploads/2022/11/CI_NEWS-2022-03.pdf.
This issue features:
* President’s Report — New Science Advisory Board.
* 2022 AGM Photos.
* Board of Directors Winners.
* Scale Model CI Cryostats for Sale.
* Cryonics Survey.
* Robert Ettinger’s YOUNIVERSE — Chapter 5
* Latest Cryonics & Life Extension News from Around the Web.
Forever Young: Scientists Reveal the Secret to a Strange Animal’s Eternal Youth
Sea anemones are seemingly immortal animals. They seem to be immune to aging and the negative impacts that humans experience over time. However, the exact reasons for their eternal youth are not completely understood.
The genetic fingerprint of the sea anemone Nematostella vectensis reveals that members of this incredibly ancient animal phylum employ the same gene cascades for neural cell differentiation as more complex organisms. These genes are also in charge of maintaining the balance of all cells in the organism during the anemone’s lifetime. These findings were recently published in the journal Cell Reports by a group of developmental biologists headed by Ulrich Technau of the University of Vienna.
Almost all animal organisms are made up of millions, if not billions, of cells that join together in intricate ways to create specific tissues and organs, which are made up of a range of cell types, such as a variety of neurons and gland cells. However, it is unclear how this critical balance of diverse cell types emerges, how it is regulated, and if the different cell types of different animal organisms have a common origin.
Warning: Popular Vitamin Supplement Causes Cancer Risk and Brain Metastasis
University of Missouri researchers made the discovery while using bioluminescent imaging technology to study how nicotinamide riboside supplements work inside the body.
Commercial dietary supplements like nicotinamide riboside (NR), a form of vitamin B3, were linked to benefits related to cardiovascular, metabolic, and neurological health in previous studies. However, new research from the University of Missouri (MU) has found NR could actually increase the risk of serious disease, including developing cancer.
Supplements containing nicotinamide riboside are often marketed as NAD+ boosters claimed benefits including increased energy, anti-aging/longevity/healthy aging, improved cellular energy metabolism and repair, increased vitality, and improved heart health.
Longitudinal Biomarker Optimization: A Road To Maximize Health And Longevity?
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What can blockchain do for increasing human longevity?
Longevity is not yet considered an official medical term, and aging is not officially considered a disease but a natural occurrence in every living thing.
However, some biologists, researchers and practicing doctors believe this approach should change, and they are striving to discover the mechanisms of aging in humans. In doing so, they are creating age clocks by defining biomarkers for measuring biological age, exploring the best lifestyle habits and natural supplements, and inventing new drugs that could stop us from getting older.
Longevity has been on the radar of crypto leaders for some time already, which is not a surprise given that the industry promises to improve humankind through innovation. Indeed, one prominent event in the longevity industry, the Longevity Investors Conference, is organized by Marc P. Bernegger and Tobias Reichmuth, who were previously involved with the Crypto Finance Group.