Lifeboat Foundation

Stem cell biologist Hugo Vankelecom (KU Leuven) and his colleagues have discovered that the pituitary gland in mice ages as the result of an age-related form of chronic inflammation. It may be possible to slow down this process or even partially repair it. The researchers have published their findings in PNAS.

The pituitary gland is a small, globular gland located underneath the brain that plays a major role in the hormonal system, explains Professor Hugo Vankelecom from the Department of Development and Regeneration at KU Leuven. “My research group discovered that the pituitary gland ages as a result of a form of chronic inflammation that affects tissue and even the organism as a whole. This natural process usually goes unnoticed and is referred to as ‘inflammaging’—a contraction of inflammation and aging. Inflammaging has previously been linked to the aging of other organs.” Due to the central role played by the pituitary, its aging may contribute to the reduction of hormonal processes and hormone levels in our body—as is the case with menopause, for instance.

The study also provides significant insight into the stem cells in the aging pituitary gland. In 2012, Vankelecom and his colleagues showed that a prompt reaction of these stem cells to injury in the gland leads to repair of the tissue, even in adult animals. “As a result of this new study, we now know that stem cells in the pituitary do not lose this regenerative capacity when the organism ages. In fact, the stem cells are only unable to do their job because, over time, the pituitary becomes an ‘inflammatory environment’ as a result of the chronic inflammation. But as soon as the stem cells are taken out of this environment, they show the same properties as stem cells from a young pituitary.”

In a minute and 27 seconds we get the what from an eye regeneration for mice, to monkey trials to start later this year, to human trials by 2023, and full body in a decade.

David Sinclair—a world-leading biologist, Harvard Medical School Professor, and author of The New York Times best-selling book @Lifespan.

Continue reading “When can we begin to apply age reversal gene therapies to humans? Harvards David Sinclair explains” »

The resulting implant consists of cells attached to the scaffold, which permits the targeted delivery of therapeutic cells to the diseased region within the eye. A non-cryopreserved formulation of this cellular therapy is being employed in an ongoing Phase I/IIa clinical trial sponsored by RPT. The cryopreserved formulation enabled by the work of Pennington and colleagues will facilitate anticipated Phase IIb and Phase III clinical trials as well as ultimate commercialization and clinical application of the product.

Scientists at UC Santa Barbara, University of Southern California (USC), and the biotechnology company Regenerative Patch Technologies LLC (RPT) have reported new methodology for preservation of RPT’s stem cell-based therapy for age-related macular degeneration (AMD).

The new research, recently published in Scientific Reports, optimizes the conditions to cryopreserve, or freeze, an implant consisting of a single layer of ocular cells generated from human embryonic stem cells supported by a flexible scaffold about 3×6 mm in size. This implant is currently in clinical trial for the treatment of AMD, the leading cause of blindness in aging populations. The results demonstrate that the implant can be frozen, stored for long periods and distributed in frozen form to clinical sites where it is designed to be thawed and immediately implanted into the eyes of patients with macular degeneration. The capacity to cryopreserve this and other cell-based therapeutics will extend shelf life and enable on-demand distribution to distant clinical sites, increasing the number of patients able to benefit from such treatments.

Continue reading “A frozen leap forward for age-related macular degeneration stem cell-based therapy” »

The World Health Organization classifies processed meat as a Group 1 carcinogen. Processed meat includes ham, sausage, bacon, pepperoni; they’re meats that have been preserved with salt or smoke, meat that has been cured, and meat treated with chemical preserves. Other Group 1 carcinogens include formaldehyde, tobacco, and UV radiation. Group 1 carcinogens have ‘enough evidence to conclude that it can cause cancer in humans.’

There is no question whether or not our current meat production complex is inhumane, unsanitary, or bad for the environment. Almost all chickens (99.9%), turkeys (99.8%), and most cows (70.4%) eaten in the United States are raised on factory farms. There are horrific consequences to this practice.

For example, the EPA estimates agriculture is the biggest contaminator of rivers and streams, to the point where feedlots, crop production, and manure runoff have led almost half (46%) of the U.S.’s rivers to be “in poor biological condition.”

Continue reading “Vegans Diets and Longevity: What Existing Science Actually Says” »

For those who track their diet, eating only the RDA for many nutrients may not optimize health. For example, the RDA for selenium is 55 micrograms per day, but is that amount optimal for reducing risk of death for all causes?

Papers referenced in the video:

Continue reading “Selenium: How Much Is Optimal For Health?” »

What Are Telomeres?

As our cells divide (a process known as mitosis), our cells replicate the long strands of DNA located within the nucleus of our cells (known as chromosomes). This process however is imperfect, and due to the mechanics of how this is carried out by the body, the DNA is shorted ever so slightly during each replication cycle. I will not get into the details on how exactly this happens in this article, but if you are interested then this video should give you a better understanding of this process. In order to prevent important parts of the DNA being lost through the replication process, areas of what is mostly blank DNA at the end of the chromosomes are used as a sort of sacrificial buffer, allowing for the DNA to be replicated without the loss of genetic information. These areas of the chromosomes are known as telomeres. In addition to providing a buffer zone for DNA replication, telomeres also prevent broken strands of DNA attaching themselves to the ends of chromosomes, which both prevents chromosomes from becoming conjoined, as well as allowing for the opportunity for the broken strand of DNA to be repaired.

Continue reading “Does Telomere Length Really Affect Lifespan?” »

Calico has made some important discoveries about Yamanaka factors.

In a preprint paper, scientists from Calico, Google’s longevity research behemoth, suggest that contrary to our previous understanding, transient reprogramming of cells using Yamanaka factors involves suppressing cellular identity, which may open the door to carcinogenic mutations. They also propose a milder reprogramming method inspired by limb regeneration in amphibians [1].

Rejuvenation that can give you cancer

Continue reading “Calico Scientists Develop Safer Cellular Reprogramming” »

Discovery in Salamanders by James W. Godwin, Ph.D., brings science closer to the development of regenerative medicine therapies.

Many salamanders can readily regenerate a lost limb, but adult mammals, including humans, cannot. Why this is the case is a scientific mystery that has fascinated observers of the natural world for thousands of years.

Now, a team of scientists led by James Godwin, Ph.D., of the MDI Biological Laboratory in Bar Harbor, Maine, has come a step closer to unraveling that mystery with the discovery of differences in molecular signaling that promote regeneration in the axolotl, a highly regenerative salamander, while blocking it in the adult mouse, which is a mammal with limited regenerative ability.

Immortal gut biome o.o

Our genetic material is stored in our cells in a specific way to make the meter-long DNA molecule fit into the tiny cell nucleus of each body cell. An international team of researchers at the Max Planck Institute for Biology of Aging, the CECAD Cluster of Excellence in Aging Research at the University of Cologne, the University College London and the University of Michigan have now been able to show that rapamycin, a well-known anti-aging candidate, targets gut cells specifically to alter the way of DNA storage inside these cells, and thereby promotes gut health and longevity. This effect has been observed in flies and mice. The researchers believe this finding will open up new possibilities for targeted therapeutic interventions against aging.

Our genetic material lies in the form of DNA in every cell nucleus of our body cells. In humans, this DNA molecule is two meters long—yet it fits into the cell nucleus, which is only a few micrometers in size. This is possible because the DNA is precisely stored. To do this, it is wound several times around certain proteins known as histones. How tightly the DNA is wound around the histones also determines which genes can be read from our genome. In many species, the amount of histones changes with age. Until now, however, it has been unclear whether changes in cellular histone levels could be utilized to improve the aging process in living organisms.

Continue reading “Rapamycin changes the way our DNA is stored” »