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Alex Zhavoronkov, ARDD2022: Pharma.AI platform for discovery and development of aging therapeutics

The Aging and Drug Discovery Conference (ARDD) 2022 is pleased to present Alex Zhavoronkov from Insilico, with the talk A case study of the application of Pharma. AI platform for discovery and development of dual-purpose therapeutics targeting aging and disease.

Held in Copenhagen at the glorious Ceremonial Hall, this meeting gathers the most prominent figures of the aging and longevity research field, from scientists to clinicians, investors, developers, and everything in between. The fast growth of the conference is evidence of its great quality of it. In 2022 we had around 400 people on-site, and many others joined through the web.

To find out more check www.agingpharma.org #ARDD #ARDD2022 #Longevity

Quantifying Biological Age: Blood Test #6 in 2022

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Planarian don’t age, there isn’t such thing as an old Planaria

Short clip of Michael Levin, an American developmental and synthetic biologist at Tufts University, talking about Planarian and their capacity to regenerate their organs indefinetely, which makes then biologically immortal.

The remarks where given during a fascinating three-hour-long conversation with Lex Fridman that was aired on october 1st, 2022.

Lex Fridman is a Russian-American computer scientist, artificial intelligence researcher, and podcast host.

To watch the entire conversation clic here: https://youtu.be/p3lsYlod5OU

A New Device for Early Diagnosis of Degenerative Eye Disorders

Summary: Researchers have developed a new ophthalmological device that can detect degenerative visual problems such as age-related macular degeneration long before the onset of the first symptoms.

Source: EPFL

Researchers at an EPFL lab have developed an ophthalmological device that can be used to diagnose some degenerative eye disorders long before the onset of the first symptoms. In early clinical trials, the prototype was shown to produce images with a sufficient degree of precision in just five seconds.

Meta what?

When in 2015, Eileen Brown looked at the ETER9 Project (crazy for many, visionary for few) and wrote an interesting article for ZDNET with the title “New social network ETER9 brings AI to your interactions”, it ensured a worldwide projection of something the world was not expecting.

Someone, in a lost world (outside the United States), was risking, with everything he had in his possession (very little or less than nothing), a vision worthy of the American dream. At that time, Facebook was already beginning to annoy the cleaner minds that were looking for a difference and a more innovative world.

Today, after that test bench, we see that Facebook (Meta or whatever) is nothing but an illusion, or, I dare say, a big disappointment. No, no, no! I am not now bad-mouthing Facebook just because I have a project in hand that is seen as a potential competitor.

I was even a big fan of the “original” Facebook; but then I realized, it took me a few years, that Mark Zuckerberg is nothing more than a simple kid, now a man, who against everything and everyone, gave in to whims. Of him, initially, and now, perforce, of what his big investors, deluded by himself, of what his “metaverse” would be.

What do Tardigrades, aka Water Bears, have in Common With Sleeping Beauty?

In the style of Sleeping Beauty, Tardigrades, the adorable, tiny animals that can withstand extreme environments and are also known as “water bears,” can withstand freezing without losing their vitality. Despite harsh environmental conditions, tardigrades are very adaptable. According to Ralph Schill, a professor at the University of Stuttgart, anhydrobiotic (dry) tardigrades can survive for many years without absorbing water. In a frozen state, there was no clear indication of whether aging increased or decreased. It turns out that frozen tardigrades don’t age.

Water bears, also known as tardigrades, are nematodes. They have the same gait as bears, but that’s about the only thing that connects them to bears. As a result of their adaptability to rapidly changing environmental conditions, tardigrades, which are barely one millimeter in size, can freeze in extreme cold and dry out in extreme heat. Rather than dying, Schill explains that they fall into a deep sleep. A cell organism experiences different types of stress when it freezes or dries out. Despite this, tardigrades are equally capable of surviving both extremes of heat and cold. No obvious signs of life can be seen on them. In this state of rest, the animal’s internal clock might be slowed down, which raises the question of whether it ages.

Schill and his team investigated the aging process of dried tardigrades several years ago, which waited in their habitat for rain for many years. Grimm brothers’ fairytales depict a princess who is deeply asleep. A young prince kisses her 100 years later, and she awakes looking as beautiful and young as ever. In a dried state, tardigrades are the same, and therefore this hypothesis is called the “Sleeping Beauty” hypothesis. Schill explains that the internal clock stops during inactivity and resumes once the organism has been reactivated. Accordingly, the researcher explained that tardigrades, whose lifespan usually lasts only a few months without rest, can survive for decades.

Scientists Successfully Reverse Premature Aging

Werner Syndrome and Hutchinson Gilford Progeria Syndrome are two examples of the rare genetic disorders known as progeroid syndromes that cause signs of premature aging in children and young adults. Patients with progeroid syndromes have pathologies and symptoms that are often linked to aging, including osteoporosis, cataracts, heart disease, and type II diabetes.

This aging is characterized by the gradual loss of nuclear architecture and an underlying tissue-specific genetic program, but the causes are unclear. Scientists have discovered a potential new target for treating these syndromes by preventing nuclear architecture loss.

Dr. Peter Fedichev, PhD — CEO, Gero — Hacking Complex Diseases & Aging with AI & Digital Biomarkers

Dr. Peter Fedichev, Ph.D. is the CEO of Gero (https://gero.ai/), a biotech company focused on hacking complex diseases, including aging, with AI for novel drug discovery, as well as digital biomarkers.

Gero’s models originate from the physics of complex dynamic systems, combining the potential of deep neural networks with the physical models to study dynamical processes and understand what drives diseases.

Dr. Fedichev has a background in biophysics, bioinformatics and condensed matter physics, earning his Ph.D. from the University of Amsterdam, and he conducted research at FOM Institute AMOLF (part of the institutes organization of the Dutch Research Council of Netherlands) and the University of Innsbruck.

To date, Dr Fedichev has published over 70 papers covering his research on physics, biophysics and aging biology.

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