Including Charlie Kam, Dr. Aubrey deGrey, Valery Chuprin, Jose Cordeiro, Gennady Stolyarov, Joseph Kowalsky & Richard Daley.
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“Our task is to make nature, the blind force of nature, into an instrument of universal resuscitation and to become a union of immortal beings.“ - Nikolai F. Fedorov.
We hold faith in the technologies & discoveries of humanity to END AGING and Defeat involuntary Death within our lifetime.
Working to Save Lives with Age Reversal Education.
In the Existential Hope-podcast (https://www.existentialhope.com), we invite scientists to speak about long-termism. Each month, we drop a podcast episode where we interview a visionary scientist to discuss the science and technology that can accelerate humanity towards desirable outcomes.
Xhope Special with Foresight Fellow Morgan Levine.
Morgan Levine is a ladder-rank Assistant Professor in the Department of Pathology at the Yale School of Medicine and a member of both the Yale Combined Program in Computational Biology and Bioinformatics, and the Yale Center for Research on Aging. Her work relies on an interdisciplinary approach, integrating theories and methods from statistical genetics, computational biology, and mathematical demography to develop biomarkers of aging for humans and animal models using high-dimensional omics data. As PI or co-Investigator on multiple NIH-, Foundation-, and University-funded projects, she has extensive experience using systems-level and machine learning approaches to track epigenetic, transcriptomic, and proteomic changes with aging and incorporate. this information to develop measures of risk stratification for major chronic diseases, such as cancer and Alzheimer’s disease. Her work also involves development of systems-level outcome measures of aging, aimed at facilitating evaluation for geroprotective interventions.
Existential Hope. A group of aligned minds who cooperate to build beautiful futures from a high-stakes time in human civilization by catalyzing knowledge around potential paths to get there and how to plug in.
Cellular reprogramming by transient expression of Yamanaka factors ameliorates age-associated symptoms, prolongs lifespan in progeroid mice, and improves tissue homeostasis in older mice.
Talking about some of the ideas and philosophy surrounding life extension technologies. Our own psychology and coping mechanisms that view death as a good thing. The same way we used to see some diseases as a part of a gods plan. As soon as we cured these diseases, somehow they were not a part of gods plan anymore. The same will happen with aging and death, and that is just a matter of time. Picking apart some of the ways of thinking that suggest a longer life would be a boring or bad thing. We live for all of the pleasant and amazing experiences that we can have in the world, what else could possibly matter more. The end and absence of meaning (death) does not give life meaning. It is life that gives life meaning.
All around smart guy Dr Goerge Church talking about genetic engineering technologies.
George Church, Ph.D. is a professor of genetics at Harvard Medical School and of health sciences and technology at both Harvard and the Massachusetts Institute of Technology. Dr. Church played an instrumental role in the Human Genome Project and is widely recognized as one of the premier scientists in the fields of gene editing technology and synthetic biology.
Modulating Autophagy To Promote Healthspan — Dr. Ana Maria Cuervo, M.D., Ph.D., Albert Einstein College of Medicine.
Dr. Ana Maria Cuervo, M.D., Ph.D. (https://www.einsteinmed.edu/faculty/8784/ana-maria-cuervo/) is Co-Director of the Einstein Institute for Aging Research, and a member of the Einstein Liver Research Center and Cancer Center. She serves as a Professor in the Department of Developmental & Molecular Biology, and the Department of Medicine (Hepatology), and has the Robert and Renée Belfer Chair for the Study of Neurodegenerative Diseases.
Dr. Cuervo studied medicine and pursued a Ph.D. in biochemistry and molecular biology at the University of Valencia, as well as post-doctoral work at Tufts, and in 2001 she started her laboratory at Einstein, where she studies the role of protein-degradation in aging and age-related disorders, with emphasis in neurodegeneration and metabolic disorders.
Dr. Cuervo’s group is interested in understanding how altered proteins can be eliminated from cells and their components recycled. Her group has linked alterations in lysosomal protein degradation (autophagy) with different neurodegenerative diseases including Parkinson’s, Alzheimer’s and Huntington’s disease. They have also proven that restoration of normal lysosomal function prevents accumulation of damaged proteins with age, demonstrating this way that removal of these toxic products is possible. Her lab has also pioneered studies demonstrating a tight link between autophagy and cellular metabolism. They described how autophagy coordinates glucose and lipid metabolism and how failure of different autophagic pathways with age contribute to important metabolic disorders such as diabetes or obesity.
Dr. Cuervo is considered a leader in the field of protein degradation in relation to biology of aging and has been invited to present her work in numerous national and international institutions, including name lectures as the Robert R. Konh Memorial Lecture, the NIH Director’s, the Roy Walford, the Feodor Lynen, the Margaret Pittman, the IUBMB Award, the David H. Murdock, the Gerry Aurbach, the SEBBM L’Oreal-UNESCO for Women in Science, the C. Ronald Kahn Distinguished Lecture and the Harvey Society Lecture. She has organized and chaired international conferences on protein degradation and on aging, belongs to the editorial board of scientific journals in this topic, and is currently co-editor-in-chief of Aging Cell.
Aging is a complex and inevitable process that affects all organisms – and it is associated with tissue dysfunction, susceptibility to various diseases, and death [1]. The development of strategies like cellular reprogramming for increasing the duration of healthy life and promoting healthy aging is difficult since the mechanism of aging is not understood clearly. Aging is known to be associated with several hallmarks of aging – such as epigenetic alterations, genomic instability, cellular senescence, telomere shortening, mitochondrial dysfunction and altered intercellular communication.
Aging can be divided into two major phases: healthy aging and pathological aging. Healthy aging is the phase where the accumulation of minor alterations takes place, but pathological aging is the phase where clinical diseases and disabilities predominate along with the impairment of physiological functions [2].
Longevity. Technology: Notions regarding cells undergoing a unidirectional differentiation process during development existed previously [3]. However, in recent years cellular reprogramming using transcription factors has emerged as an important strategy for the rejuvenation of aging cells, erasing markers of cell damage and restoring epigenetic markers. These transcription factors also known as Yamanaka factors include Oct4, Sox2, Klf4, and c-Myc (OSKM). They can convert terminally differentiated somatic cells into pluripotent stem cells which are capable of dividing into any cell type of the body and thus can improve the health and longevity of individuals.
