Circa 2020 Reversing the biological clock to essentially reverse aging.
Expression of three Yamanaka transcription factors in mouse retinal ganglion cells restores youthful DNA methylation patterns, promotes axon regeneration after injury, and reverses vision loss in a mouse model of glaucoma and in aged mice, suggesting that mammalian tissues retain a record of youthfu…
Scientists at the University of Virginia School of Medicine and their collaborators have used DNA to overcome a nearly insurmountable obstacle to engineer materials that would revolutionize electronics.
Scientists around the world are scurrying to reverse the hands of time. Here’s a look at one lab’s search for the fountain of youth, where old mice have grown young again.
𝐖𝐡𝐚𝐭 𝐜𝐚𝐧 𝐬𝐞𝐚 𝐬𝐪𝐮𝐢𝐫𝐭𝐬 𝐭𝐞𝐥𝐥 𝐮𝐬 𝐚𝐛𝐨𝐮𝐭 𝐧𝐞𝐮𝐫𝐨𝐝𝐞𝐠𝐞𝐧𝐞𝐫𝐚𝐭𝐢𝐨𝐧?
A tiny marine creature with a strange lifestyle may provide valuable insights into human neurodegenerative disorders, such as Alzheimer’s disease, according to scientists at Stanford Medicine.
Botryllus schlosseri, also called a star tunicate, is humans’ closest evolutionary relative among invertebrates in the sea. Attached to rocks along the coast, it appears as a tiny flower-shaped organism. Star tunicates start life as little tadpole-like creatures with two brains, swimming in the ocean. But eventually they drift down from the surface, settling into a stationary life on a rock, joining a colony of other tunicates.
As the tunicate, also known as a sea squirt, adapts to its new couch-potato lifestyle, it loses brain power: One of the two brains, its use for sea navigation now obsolete, begins to dissolve. The way the invertebrate’s brain degenerates and disappears has important parallels to the way the brain degenerates in human neural disorders, said Irving Weissman, MD, director of the Institute for Stem Cell Biology and Regenerative Medicine.
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Summary: Study reveals how somatostatin and copper affect amyloid beta in Alzheimer’s disease pathology.
Source: KAIST
With nearly 50 million dementia patients worldwide, and Alzheimers’s disease is the most common neurodegenerative disease. Its main symptom is the impairment of general cognitive abilities, including the ability to speak or to remember.
The importance of finding a cure is widely understood with increasingly aging population and the life expectancy being ever-extended. However, even the cause of the grim disease is yet to be given a clear definition.
Throughout life, cells of the body acquire somatic mutations. In frozen post-mortem human brains, researchers from Yale University have found that somatic, or non-inherited, mutations are considerably more likely to accumulate in roughly 6% of brains, and these “hypermutable” brains are typically 40 years of age or older.
The behavior, comparable to clonal hematopoiesis in the bone marrow that can result in blood cancer in elderly people, is attributed to cell lines with mutations that outcompete other cell lines.
This is the first large-scale study of somatic mutations in human brains. Scientists were not expecting to find this hypermutability in older populations.
“DEATH DEFANGED Cryonics, Cryothanasia and the Future of Sentience” with David Pearce, Author, Philosopher and well-known TransHumanistThis service will be on ZOOM and YouTube Live Stream only, not in person.
Zoom at 6:00 PM Eastern Time.
Live Stream at 7:00 PM Eastern Time.
Stay after the close of the YouTube streaming for the Zoom After Party until??:00 pm. Enjoy fellowship in the extended discussions with Neal and Immortalists & Friends from Around the World, sharing bold ideas on health, longevity, and technology!(Note: Mr. Pearce was scheduled last month to give a presentation but due to circumstances beyond our control we did not have that presentation. We look forward this month to have David Pearce join us!)David Pearce is the author of 4 major works:“The Hedonistic Imperative”, “The Biointelligence Explosion: How Recursively Self-Improving Organic Robots will Modify their Own Source Code and Bootstrap Our Way to Full-Spectrum Superintelligence”, “Singularity Hypotheses: A Scientific and Philosophical Assessment”, & “Can Biotechnology Abolish Suffering?”
The Hedonistic Imperative (1995) advocates the use of biotechnology to abolish suffering throughout the living world. In 1998, he co-founded the World Transhumanist Association (H+) with Nick Bostrom. Transhumanists believe in the use of technology to overcome our biological limitations.
Currently, Pearce is a fellow of the Institute for Ethics and Emerging Technologies, and sits on the futurist advisory board of the Lifeboat Foundation. He is also the director of bioethics of Invincible Wellbeing and is on the advisory boards of the Center on Long-Term Risk, the Organization for the Prevention of Intense Suffering and since 2021 the Qualia Research Institute. Please share this event with someone that you care about. Would you like to make a Donation to Perpetual Life? Your donations help us grow & improve our services. To donate, go to our website http://Perpetual.Life and use the PayPal button at the top right of the page. Thank you for your generous donations, we appreciate it immensely!“Our task is to make nature, the blind force of nature, into an instrument of universal resuscitation and to become a union of immortal beings.“
- Nikolai F. FedorovWe hold faith in the technologies & discoveries of humanity to END AGING and Defeat involuntary Death within our lifetime. Working to Save Lives with Age Reversal Education. ========== Perpetual Life Creed ==========We believe that all of life is sacred and that we have been given this one life to make unlimited. We believe in our Creator’s divine plan for all of humanity to have infinite lifespans in perfect health and eternal joy, rendering death to be optional. By following our Gospel we achieve eternal life creating a heaven here on earth. We follow Nikolai Fyodorov, who taught that the transcendence of the creator will only be solved when humanity in our unified efforts become an instrument of universal resuscitation, when the divine word becomes our divine action. And we follow Arthur C. Clarke, who said “The only way to discover the limits of the possible is to go beyond them into the impossible.“And so, we enter each day energized in Spirit and empowered by the words of our prophets to live in joy, serving our creator and all of mankind, Forever and Ever.==========Wishing you Perfect Health and Great Longevity!Perpetual Life, a science-faith based church is open to people of all faiths & belief systems. We are non-denominational & non-judgmental and a central gathering place of Immortalists & Transhumans. What unites us is our common faith, belief and desire in Unlimited Life Spans. We are located in Pompano Beach FL at 950 South Cypress Road.
Observational studies of the relationship between alcohol use and telomere length have produced conflicting results. The largest such study to date, of 4,567 individuals, found no association between alcohol intake and either baseline or longitudinal change in telomere length [9]. Another analysis of two American cohorts (n = 2623) also reported null findings [10]. On the other hand, a few small studies (sample size range: 255‑1800) have observed associations with heavy drinking or AUD. Participants with AUD have been reported to have shorter telomeres compared to healthy controls [11]. A longitudinal study of Helsinki businessmen observed that higher midlife alcohol consumption was associated with shorter telomere length in older age [8]. Drinking 30 g/day of alcohol in older participants was associated with shorter telomeres in a Korean study [12]. Associations were stronger in those experiencing the alcohol flush reaction, raising the intriguing possibility that acetaldehyde, ethanol’s toxic breakdown product, is mechanistically involved. In a recent review of 27 studies, 10 showed significant associations between alcohol use and telomere length [13]. The studies included cross-sectional and longitudinal designs. The majority comprised European participants with ages ranging from the third to seventh decade. Most studies observed positive associations between alcohol and LTL. However heterogeneity between studies in methods of quantifying telomere length and categorizing alcohol intake hindered meta-analysis and aggregation of the data.
MR seeks to identify potentially causal determinants of an outcome. It estimates the association between genetically predicted levels of an exposure and an outcome of interest. Residual confounding and reverse causation aim to be less of a concern than in most other methods of analyzing observational data [14]. With MR, genetic proxies can be used to study the effects of genetically-predicted variability in alcohol consumption or AUD risk. To our knowledge, no MR study of alcohol and telomere length has yet been attempted.
We conducted a large observational study of two alcohol phenotypes, alcohol consumption and AUD, and leucocyte. We then performed linear MR analyses to investigate the evidence for a causal effect between alcohol consumption/AUD and LTL. Estimates generated by our observational and genetic methods were compared. Genetic distinction between different alcohol use traits motivates their separate analysis. Quantity/frequency measures such as drinks per week and AUDIT-C (Alcohol Use Disorders Identification Test Consumption, a 3 item screening tool), while moderately genetically correlated with AUD, have distinct patterns of genetic correlation with other traits [13]. Furthermore, as there has been much speculation about potential J-shaped relationships between alcohol and health outcomes [15], we performed a non-linear MR analysis to examine the shape of the relationship between alcohol consumption and telomere length.
Join us on Patreon!
https://www.patreon.com/MichaelLustgartenPhD
Bristle Discount Link (Oral microbiome quantification):
ConquerAging15
https://www.bmq30trk.com/4FL3LK/GTSC3/
Cronometer Discount Link (Daily diet tracking):
https://shareasale.com/r.cfm?b=1390137&u=3266601&m=61121&urllink=&afftrack=
You can support the channel by buying me a coffee!
https://www.buymeacoffee.com/mlhnrca.
Levine’s Biological age calculator is embedded as an Excel file in this link from my website:
