The search for a fountain of youth has obsessed humankind for millennia, but a new wave of research is showing that the secret may have been running through our veins all along.
Dr. Jennifer Garrison, PhD (http://garrisonlab.com/) is Assistant Professor, Buck Institute for Research on Aging, Founder & Faculty Director, Global Consortium for Reproductive Longevity & Equality (https://www.buckinstitute.org/gcrle/), Assistant Professor in Residence, Cellular and Molecular Pharmacology, UCSF and Adjunct Assistant Professor of Gerontology, USC Leonard Davis School of Gerontology.
Dr. Garrison’s lab is interested in understanding how neuropeptides (a large class of signaling molecules which are secreted from neurons and transmit messages within the brain and across the nervous system) regulate changes in normal and aging animals as well in understanding how they control behavior at both the cell biological and neural circuit level.
We interviewed four longevity experts (including several Lifeboat Foundation board members) to learn how they think about their diets. I was particularly struck by how different they all were (except almost all of them fasted)!
Food.
In all our research into longevity so far, from quantifying how we sleep to exploring the science behind whether human life extension is possible, nutrition has remained the most controversial and confusing subject that we’ve covered. For example, when we surveyed 101 of our readers on their longevity diet, we got 101 very different answers. There is little consensus on what the perfect life extension diet should look like.
In case this hasn’t been posted here yet.
Ageing is inevitable, but what if everything we’ve come to believe about ageing is wrong and we’re able to choose our lifespans? What if ageing is a disease?
Continue reading “Do we finally have control over ageing? | Prof David Sinclair” »
A DNA robot that can walk across biological cell membranes is the first one that can control living cells’ behaviour. The researchers who made the robot hope that it could improve cell-based precision medicine.
A team led by Hong-Hui Wang and Zhou Nie from Hunan University, China, has created a synthetic molecular robot that walks along the outer membrane of biological cells. The robot, powered by an enzyme’s catalytic activity, traverses across receptors that act as stepping stones on the cell surface. With each step, the robot activates a signal pathway that regulates cell migration. Driven by the robot’s movement, the cells can reach speeds of 24 μm/hour.
The researchers write that the DNA robot offers, for the first time, an opportunity to accurately and predictably control the nanoscale operations that power a live cell. They suggest that similar molecular machines that guide cell behaviours could play a role in cell-based therapies and regenerative medicine.
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Levine’s Biological age calculator is embedded as an Excel file in this link:
https://michaellustgarten.com/2019/09/09/quantifying-biological-age/
Continue reading “Attempting To Further Reduce Biological Age: hs-CRP” »
All things must die, according to the poet Alfred Lord Tennyson, but that could be about to change.
A growing number of tech billionaires have decided they want to use their enormous wealth to try to help humans “cheat death.”
Amazon’s Jeff Bezos, Alphabet’s Larry Page, Oracle’s Larry Ellison and Palantir’s Peter Thiel are just a few of the super-rich who have taken a keen interest in the fast-emerging field of longevity, according to interviews, books and media reports.
A deepening understanding of the brain has created unprecedented opportunities to alleviate the challenges posed by disability. Scientists and engineers are taking design cues from biology itself to create revolutionary technologies that restore the function of bodies affected by injury, aging, or disease — from prosthetic limbs that effortlessly navigate tricky terrain to digital nervous systems that move the body after a spinal cord injury.
With the establishment of the new K. Lisa Yang Center for Bionics, MIT is pushing forward the development and deployment of enabling technologies that communicate directly with the nervous system to mitigate a broad range of disabilities. The center’s scientists, clinicians, and engineers will work together to create, test, and disseminate bionic technologies that integrate with both the body and mind.
Is an academic doctor and medical technology entrepreneur, working in the field of the computational biology of aging.
Dr. Radenkovic is also a Partner at the SALT Bio-Fund, and a co-founder of Hooke, an elite longevity research clinic in London.
Red blood cells are the most abundant cell type in blood, carrying oxygen throughout the human body. In blood circulation, they repetitively encounter various levels of oxygen tension. Hypoxia, a low oxygen tension condition, is a very common micro-environmental factor in physiological processes of blood circulation and various pathological processes such as cancer, chronic inflammation, heart attacks and stroke. In addition, an interplay between poor cellular deformability and impaired oxygen delivery is found in various pathological processes such as sickle cell disease. Sickle red blood cells simultaneously undergo drastic mechanical deformation during the sickling and unsickling process.
The interactions between hypoxia and cell biomechanics and the underlying biochemical mechanisms of the accelerated damage in diseased red blood cells are well understood, however, the exact biomechanical consequences of hypoxia contributing to red blood cell degradation (aging) remains elusive.
Researchers from Florida Atlantic University’s College of Engineering and Computer Science, in collaboration with the Massachusetts Institute of Technology (MIT), sought to identify the role of hypoxia on red blood cell aging via the biomechanical pathways. In particular, they examined hypoxia-induced impairment of red blood cell deformability at the single cell level, compared the differences between non-cyclic hypoxia and cyclic hypoxia, and documented any cumulative effect vs. hypoxia cycles, such as aspects that have not been studied quantitatively. Red blood cell deformability is an important biomarker of its functionality.
