Lifeboat Foundation

This month, the UW team upped their game.

Tapping into both AlphaFold and RoseTTAFold, they tweaked the programs to predict which proteins are likely to tag-team and sketched up the resulting complexes into a 3D models.

Using AI, the team predicted hundreds of complexes—many of which are entirely new—that regulate DNA repair, govern the cell’s digestive system, and perform other critical biological functions. These under-the-hood insights could impact the next generation of DNA editors and spur new treatments for neurodegenerative disorders or anti-aging therapies.

Very well said and in just one minute by Dr. Eric Verdin, CEO & President of the Buck Institute for Research on Aging.

Videoclip of the intervention of Dr. Eric Verdin, CEO & President of the Buck Institute for Research on Aging, referring to Longevity as an investment opportunity.

Continue reading “Longevity as an investment opportunity | Videoclip with Dr. Eric Verdin (S/T in Spanish)” »

It’s the BIG one! The FINAL LEVEL on the Kardashev Scale! In this video, Unveiled discovers what the world would be like if humanity could complete the Kardashev Scale and become the most advanced civilisation it’s possible to be… This goes beyond gods and monsters, to the incredible, immortal heart of the omniverse!

Let us know what you think in the comments!

Continue reading “What If Humanity Was a Type VII Civilization? | Unveiled” »

In one of the mysteries of mammalian development, every cell in the early female embryo shuts down one of its two copies of the X chromosome, leaving just one functional. For years, the mechanics behind this X chromosome inactivation have been murky, but scientists from the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have now taken a major step forward in understanding the process.

Their findings, based on research on mouse stem cells, upend previous assumptions about how X inactivation is initiated in female embryos and could lead to new ways to treat some genetic disorders, as well as a better understanding of how genes on other chromosomes are silenced.

“X inactivation is one of the most fundamentally important processes in development, and I think this study is a slam dunk in finally understanding it,” said Kathrin Plath, a professor of biological chemistry and senior author of the paper, published in the journal Cell.

https://www.youtube.com/watch?v=X1TYqoR-qVA

We explore human enhancement and personal performance hacking with Matt Ward (@mattwardio), host of The Disruptors podcast, startup investor, adviser, and business innovation consultant. Matt and I thought it would be fun to do two episodes, one here on MIND & MACHINE and the other on The Disruptors, where we explore what we’ve learned, the ideas we’ve formed and our takeaways across all these different fields that we cover.

So with this episode here on MIND & MACHINE, we focus on human enhancement — technologies that are extending lifespan and enhancing human capability. Then we get into what Matt and I are doing currently to maximize our own performance capabilities — our ability to think more clearly, to live more energetic vibrant lives… which is all heavily informed by all these amazing guests across these different fields that we explore.

Continue reading “Human Enhancement & Personal Performance Hacking with Matt Ward of ‘The Disruptors’” »

Taking a daily multivitamin for 3 years is associated with a 60% slower cognitive aging, with the effects particularly pronounced in patients with cardiovascular (CVD) disease, new research suggests.

In addition to testing the effect of a daily multivitamin on cognition, the COSMOS-Mind study also examined the effect of cocoa flavonols, but showed no beneficial effect.

The results “may have important public health implications, particularly for brain health, given the availability of multivitamins and minerals and their low cost and safety,” said research researcher Laura D. Baker, PhD, professor, Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.

One-minute-long excerpt of the intervention of Professor David Sinclair during an event organized by the SALT Fund, that took place in October.

In this excerpt, Professor Sinclair talks about the work done in his Lab at Harvard University on partial cellular reprogramming and rejuvenation.

Continue reading “David Sinclair on partial cellular reprograming and rejuvenation (with S/T in Spanish)” »

Scientists surveyed dozens of species’ genomes to uncover keys to longevity.

Innovation At The Intersection Of Cancer & Aging, Via Digital Health & Behavioral Sciences — Dr. Corinne Leach, Ph.D. American Cancer Society

Dr. Corinne Leach, PhD, MPH, MS, is a gerontologist, digital health strategist, and behavioral scientist, who serves as the Senior Principal Scientist, Behavioral Research, at the American Cancer Society (https://www.cancer.org/).

Continue reading “Dr Corinne Leach, Ph.D. — Gerontology, Digital Health, Behavioral Science — American Cancer Society” »