August 9, 2022 – A new national poll of registered voters in the United States demonstrates broad bipartisan support for advancing research into longevity treatments that would extend healthy human lifespan.
The signaling protein, known as mTOR, is excessively active in many cancer cells and plays a key role in various diseases, such as diabetes, inflammation, and aging. Meanwhile, autophagy is well-known for its elaborately mediated regulation of activity by the mTOR protein in cells. Inhibiting this activity of the mTOR protein can increase autophagy and subsequently induce cancer cell death.
Professor Kim Se-yun’s research team conducted a study on developing an mTOR-inhibitory anticancer drug with a drug regeneration strategy based on effective binding technology that models physical interactions between compounds and target proteins using the three-dimensional protein structure.
Drug regeneration finds new indications for FDA-approved drugs or clinical drug groups previously proven safe. According to the researchers, this strategy can innovatively shorten the enormous time and investment in new drug development that traditionally takes more than 10 years.
Researchers at the Hebrew University of Jerusalem have discovered a new family of molecules that enable cells to repair damaged components, making it possible for those tissues to retain proper function. The efficacy of the molecules was demonstrated on a model organism – the C. elegans roundworm. The research team examined the effect of various therapies on longevity and quality of life, and successfully showed they can protect the worm and human cells from damage.
The researchers, led by Professors Einav Gross and Shmuel Ben-Sasson, have founded a company called Vitalunga to advance the research and translate it into therapeutics.
Longevity. Technology: A major factor in aging tissues is the reduced effectiveness of our cell’s quality-control mechanism, which leads to the accumulation of defective mitochondria – the cellular ‘power plants’ responsible for energy production. Mitochondria can be compared to tiny electric batteries that help cells function properly. Although these ‘batteries’ wear out constantly, our cells have a sophisticated mechanism called mitophagy that removes defective mitochondria and replaces them with new ones. However, this mechanism declines with age, leading to cell dysfunction and deterioration in tissue activity, and is implicated in many age-related diseases, such as Alzheimer’s disease, Parkinson’s disease, heart failure and sarcopenia.
Why do some animals live longer than others?
Is aging inevitable, like the rusting of a tin can, or in some sense preprogrammed?
The answers to these questions could drastically improve human health. My latest piece for BioViva Sciences is a concise overview of the comparative biology of aging.
Being bilingual slows down the negative effects of aging on the brain.
Our brains start slowing down in their once-magical abilities after a certain age.
Scientists have been finding out is that there are methods that can slow down the aging of the brain.
Continue reading “Want to protect your brain from aging? Learn another language” »
Specific proteins in prokaryotes detect viruses in unexpectedly direct ways.
Bacteria use a variety of defense strategies to fight off viral infection. STAND ATPases in humans are known to respond to bacterial infections by inducing programmed cell death in infected cells. Scientists predict that many more antiviral weapons will be discovered in the microbial world in the future. Scientists have discovered a new unexplored microbial defense system in bacteria.
Researchers uncovered specific proteins in prokaryotes (bacteria and archaea) that detect viruses in unexpectedly direct ways, recognizing critical parts of the viruses and causing the single-celled organisms to commit suicide to stop the infection within a microbial community, according to a press release published in the official website of the Massachusetts Institute of Technology (MIT) on Thursday.
Continue reading “MIT researchers discover bacteria’s new antiviral defense system” »
But what I find even more interesting is that as metaverse tools like Nvidia’s Omniverse become more consumer friendly, the ability to use AI and human digital twins will enable us to create our own worlds where we dictate the rules and where our AI-driven digital twins will emulate real people and animals.
At that point, I expect we’ll need to learn what it means to be gods of the worlds we create, and I doubt we are anywhere near ready, both in terms of the addictive nature of such products and how to create these metaverse virtual worlds in ways that can become the basis for our own digital immortality.
Continue reading “The Metaverse Future: Are You Ready To Become a God?” »
Researchers at the Wake Forest Institute for Regenerative Medicine (WFIRM), North Carolina, are investigating the power of cells with regenerative effects. These researchers were the first to identify that stem cells in human urine have the potential for tissue regenerative effects, and are now continuing their investigation.
In a new study, the researchers have focused on how telomerase activity affects the regenerative potential of stem cells in human urine and other types of stem cells. The study was recently published in the journal Frontiers in Cell and Developmental Biology.
All Sheekey vids are a must,.
A landmark study that came out in 2005 showed that if you fused the blood systems of old and young mice, a process known as heterochronic parabiosis, it rejuvenated the cells of old mice. It suggested that there was something in the blood and there were two possible explanations; there were rejuvenating factors in the young blood, or there was dilution of pro-aging factors in the old blood. Or some combination of both.
