Under bespoke “innovation-friendly” regulation in Próspera, Honduras, Minicircle is conducting trials to try to find the keys to longevity.
Category: life extension – Page 172
This has been the news lately. This is a good breakdown of info and apparently Katcher wishes to do dog trials.
In this video we provide a quick update on activities at Yuvan Research. It is very exciting to see that Sima, the last remaining rat in the E5 trial is still alive and has surpassed the age of the previous record for lifespan of a Sprague Dawley rat.
Dr Katcher’s Interview: _https://www.youtube.com/watch?v=DpIbEluiN3o_
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Article in the Guardian: _https://www.theguardian.com/science/2023/feb/08/anti-ageing-…g-lab-rat_
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From creator Brad Wright, who honed his expertise writing on three Stargate shows for 14 years, Travelers is a departure from traditional sci-fi tropes. It’s the kind of modern, grounded sci-fi that funnels its wriggling ball of time travel strands through the lenses of empathetic, endearing characters.
This team of time-traveling agents, called “travelers,” inhabit the bodies of people who are close to death. With the help of GPS coordinates, historical records and social media, the consciousnesses of the future travelers are inserted into the bodies of 21st century civilians. It’s the cleanest way for the travelers to go back in time and complete their mission, utilizing the lives of those who were going to die anyway.
If you haven’t developed a coping mechanism for deeply human and heart-shattering experiences of grief and loss, Metaverse has something for you.
As per the recent claims made by the founder of Somnium Space, a top metaverse company, the launch of ChatGPT has accelerated the process of making one of his most ambitious and eccentric projects real.
“Honestly, it is progressing at a much faster pace than everyone’s expectations.”
Andrey Suslov/iStock.
“The AI is growing at an extremely fast pace,” Artur Sychov, the CEO of Somnium Space, whose organization at present is working to develop a “Live Forever” mode for robot avatars in its “virtual reality world,” told Motherboard.
Rheumatoid arthritis (RA), known as “immortal cancer,” is a chronic, progressive autoimmune inflammatory disease. The development and application of an RA high-sensitivity theranostics probe can help to accurately monitor the progression and realize the efficient treatment of RA.
In a study published in Advanced Science, a research group led by Prof. Zhang Yun from Fujian Institute of Research on the Structure of Matter of the Chinese Academy of Sciences developed a dual-triggered theranostics nanoprobe based on persistent luminescence nanoparticles (PLNPs) for RA autofluorescence-free imaging-guided precise treatment and therapeutic evaluation.
The researchers first prepared a renewable near-infrared (NIR)-emitting Zn1.3 Ga1.4 Sn0.3 O4:0.5%Cr3+, 0.3%Y3+ (ZGSO) PLNPs by a facile mesoporous silica template method.
The results from Katcher’s latest study will be written up when Sima dies, but data gathered so far suggests that eight rats that received placebo infusions of saline lived for 34 to 38 months, while eight that received a purified and concentrated form of blood plasma, called E5, lived for 38 to 47 months. They also had improved grip strength. Rats normally live for two to three years, though a contender for the oldest ever is a brown rat that survived on a restricted calorie diet for 4.6 years.
“The real point of our experiments is not so much to extend lifespan, but to extend youthspan, to rejuvenate people, to make their golden years really potentially golden years, instead of years of pain and decrepitude,” Katcher said. “But the fact is, if you manage to do that, you also manage to lengthen life and that’s not a bad side-effect.”
Results from such small studies are tentative at best, but some scientists believe the work, and similar efforts by others, has potential. A preliminary study from a collaboration between Katcher and experts at the University of California in Los Angeles found that infusions of young blood plasma wound back the biological clock on rat liver, blood, heart and a brain region called the hypothalamus. Commenting on the work in 2020, Prof David Sinclair, a leading expert on ageing at Harvard medical school, said if the finding held up, “rejuvenation of the body may become commonplace within our lifetimes”.
EXCLUSIVE: Clones are the next step in extending human life, scientist believes The technique has proved successful in animals but not yet worked in people Dr Alex Zhavoronkov believes it will offer ‘spare’ organs for people as they age Regardless of the huge strides scientists have made towards reaching the elusive goal, immortality remains a pipedream.
Injury to the spinal cord often leads life changing disability, with decreased or complete loss of sensation and movement below the site of injury. From drugs to transplantation, there are many scientific advances aiming to restore function following spinal cord injury.
One promising approach is the use of stem cell derived neurons to replace those damaged. New research from the Centre for Gene Therapy & Regenerative Medicine and Centre for Neurodevelopment at King’s College London hopes to improve on this approach by providing pure populations of neurons made from stem cells.
The spinal cord is a delicate structure, with neurons carry messages from your brain to the rest of your body to allow movement and sensation. Integral to this system are interneurons, or the cells that relay information between your brain and other neurons. Research has previously shown that transplanting a class of interneurons, ventral spinal interneurons, to treat spinal cord injury in animal models provides promising recovery of sensory and motor function.
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Michael Levin, Tufts Center for Regenerative and Developmental Biology.
Bioelectric Networks: Taming the Collective Intelligence of Cells for Regenerative Medicine.
Michael Levin, Distinguished Professor in the Biology department and Vannevar Bush Chair, serves as director of the Tufts Center for Regenerative and Developmental Biology. Recent honors include the Scientist of Vision award and the Distinguished Scholar Award. His group’s focus is on understanding the biophysical mechanisms that implement decision-making during complex pattern regulation, and harnessing endogenous bioelectric dynamics toward rational control of growth and form. The lab’s current main directions are:
• Understanding how somatic cells form bioelectrical networks for storing and recalling pattern memories that guide morphogenesis;
• Creating next-generation AI tools for helping scientists understand top-down control of pattern regulation (a new bioinformatics of shape); and.
• Using these insights to enable new capabilities in regenerative medicine and engineering.
Prior to college, Michael Levin worked as a software engineer and independent contractor in the field of scientific computing. He attended Tufts University, interested in artificial intelligence and unconventional computation. To explore the algorithms by which the biological world implemented complex adaptive behavior, he got dual B.S. degrees, in CS and in Biology and then received a PhD from Harvard University. He did post-doctoral training at Harvard Medical School (1996−2000), where he began to uncover a new bioelectric language by which cells coordinate their activity during embryogenesis. His independent laboratory (2000−2007 at Forsyth Institute, Harvard; 2008-present at Tufts University) develops new molecular-genetic and conceptual tools to probe large-scale information processing in regeneration, embryogenesis, and cancer suppression.
Age catches up with us all eventually, but in some people the right genes can make that chase into our twilight years a relatively leisurely one.
A few years ago Italian researchers discovered something special about people who live well into their 90s and beyond: they commonly have a version of a gene called BPIFB4 that protects against cardiovascular damage and keeps the heart in good shape for a longer period of time.
By introducing the mutated gene into older mice, the scientists have now seen how the variant rewinds markers of biological heart aging by the equivalent of more than 10 human years.