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Category: life extension – Page 168

Decoding the Aging Process: The Impact of Blood Dilution on Biological Age (Irina Conboy at EARD)

In short blood dilution is very, very good for you.

In this talk, Dr. Irina Conboy discusses the role of repair and regeneration in lifespan and healthspan, contending that these factors, rather than entropy and time progression, truly govern our aging process. She describes the research her team is pursuing, investigating whether improving the efficiency of bodily repair in older individuals could effectively make them younger. She suggests that biological age could potentially be reversed and discusses heterochronic parabiosis and plasma dilution as potential ways to accomplish that. Conboy highlights recent research suggesting that old blood has a greater impact on cellular health and function than young blood. She presents her team’s experimental research on the rejuvenation effects of plasma dilution, demonstrating its significant impact on reducing senescence, neuroinflammation, and promoting neurogenesis in the brains of old mice.

00:00:00 — Importance of repair and regeneration in aging.
00:04:45 — Young blood vs. old blood, heterochronic parabiosis.
00:10:17 — Plasma dilution is key.
00:15:49 — Kiana Aran’s blood heterochronicity on a chip.
00:17:56 — The role of senescence in parabiosis and blood exchange.
00:27:53 — Measurements of biological age.
00:36:57 — Systemic calibration is globally rejuvenative.
00:37:30 — Conclusions.

About the Speaker:
Irina Conboy is a Professor at the University of California, Berkeley in the Department of Bioengineering. Her discovery of the rejuvenating effects of young blood through parabiosis in a seminal paper published in Nature in 2005 paved the way for a thriving field of rejuvenation biology. The Conboy lab currently focuses on broad rejuvenation of tissue maintenance and repair, stem cell niche engineering, elucidating the mechanisms underlying muscle stem cell aging, directed organogenesis, and making CRISPR a therapeutic reality.

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The role of Newtic1 protein in limb regeneration in adult newts

Year 2022 This new protein Newtic1 holds promise to fully understanding limb regeneration in humans. Still though genetic engineering will be needed to fully integrate the ability for limb and body part regeneration.

The animal kingdom exhibits a plethora of unique and surprising phenomena or abilities that include, for some animals, the ability to regenerate body parts irrespective of age. Now, researchers from Japan have discovered that the mechanisms behind this peculiar ability in newts have a few surprises of their own.

Save the date: Rejuvenation Startup Summit 2024: May 10–11 in Berlin

The Forever Healthy Foundation is pleased to announce the second edition of the Rejuvenation Startup Summit, following the inaugural Rejuvenation Startup Summit in 2022 with more than 400 participants from over 30 countries. It will take place on 10–11 May 2024 in Berlin. The Rejuvenation Startup Summit is the world’s largest in-person gathering of longevity startups. It brings together startups, members of the longevity venture capital / investor ecosystem, and researchers interested in starting or joining a startup – all with the goal of accelerating the development of the rejuvenation biotech industry.

Will My Son’s Blood Make Me Younger?

At Blueprint we’ve explored and evaluated hundreds of anti-aging therapies.

Recently, we had a daring idea: what if my father, son and I completed the world’s first ever multi-generational plasma exchange?

Plasma is the yellowish, liquid part of your blood. There is emerging evidence that plasma exchanges may offer various health benefits.

Nervous but excited, we travelled to a transfusion centre in Dallas Texas to make it happen.

🧪 WHAT IS BLUEPRINT
I’ve invested millions of dollars building the world’s leading anti-aging protocol, becoming the most measured human in history. Blueprint is an algorithm, built by science, that takes better care of me than I can myself.

And it’s available to you for free. Check out the Blueprint website for recipes, exercise, and other protocols. Become the next evolution of human.

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Slowing the aging of the intestine in fish slows the aging of the entire organism, discover scientists

Lifespan by simply slowing the aging of an organ, such as the intestine? CNRS researchers have discovered how to extend the life expectancy of zebrafish by reactivating a gene within intestinal cells. The results were published in the journal Nature Aging on May 4, 2023.

The intestine plays a crucial role in an anti-aging approach as well as general health. Over a century ago, Elie Metchnikov observed that aging ensued from increased inflammation of the intestine and microbial infiltration within . The more we age, the less the serves as a barrier, allowing the undesirable particles and bacteria that cause the more rapid aging of the organism to pass through.

In a new study, Miguel Godinho Ferreira and his team at the Institute for Research on Cancer and Aging (Ircan) in Nice (CNRS/Inserm/Université Côte d’Azur) have studied the impact on aging of telomere length in the intestinal cells of zebrafish. As with humans, these chromosome extremities shrink faster in the than in other organs during the course of a life, which is why this process plays such an important role in aging.

Perpetual Life Hybrid Party w/ Erik Nelson, presents “Into the World of Longevity Medicine” and “NEW Age Reversal Updated” Presented by Bill Faloon

Join us at 6:00 pm EST (11:00 pm UTC) for our Perpetual Life Hybrid Party live from our new location at 950 South Cypress Road in Pompano Beach, FL, & socialize with Immortalists from Around the World, hosted by hosted by Tonya Scholz & Rudi Hoffman.

Stay “In Zoom” for our 7:00 pm (12:00 am-midnight UTC) YouTube Streaming Service. This month, we are excited to have two speakers. First, Erik Nelson, Director of Clinical Programs at The Healthy Longevity Clinic, will present “Into the World of Longevity Medicine.”

Second, Bill Faloon: A founder of The Church of Perpetual Life and a leader in the Global Age Reversal movement, Bill will give a NEW Age Reversal Update at this service.

Experiment Reveals How The Mediterranean Diet Works at The Cellular Level

The Mediterranean diet has become famous far beyond its namesake sea, as research increasingly supports its longstanding reputation for boosting health and longevity.

Studies have shown that people on the Mediterranean diet – which emphasizes plant-based foods and fish, and not so much red meat or dairy – tend to be healthier in multiple ways, with lower rates of heart disease, cancer, diabetes, dementia, and overall mortality.

But why? Despite strong evidence for health benefits, it remains unclear how exactly this mix of foods, at the cellular level, can lengthen lifespan.

AI technology may help to immortalize his performaces, says Tom Hanks

In a conversation during an episode of the Adam Buxton podcast, the veteran performer recently voiced his opinion regarding the likelihood of actors being kept alive in movies through the power of advanced technologies.

Known for his iconic roles in numerous blockbuster films like Forest Gump and Cast Away, the actor said that such technologies can be leveraged to recreate his image, voice, and mannerisms, from “now until kingdom come,” said Tom in the podcast.

🧠 Aubrey de Grey: AI, in silico, LEV Foundation, Alpha Fold, Nanobots, OpenAI and Sam Altman

Aubrey: 50% chance to LEV in 12–15 years, and a variety of topics from Rey Kurzweil to A.I. to Singularity, and so on.

In this podcast, Aubrey de Grey discusses his work as President and CSO at Lev Foundation and co-founder at Sense Research Foundation in the field of longevity. He explains how the Foundation’s focus is to combine rejuvenation and damage repair interventions to have greater efficacy in postponing aging and saving lives. De Grey believes that within 12 to 15 years, they have a 50% chance of achieving longevity escape velocity, which is postponing aging and rejuvenating the body faster than time passes. De Grey acknowledges the limitations of traditional approaches like exercise and diet in postponing aging and feels that future breakthroughs will come from high-tech approaches like skin and cell therapies. He discusses the potential of AI and machine learning in drug discovery and the possibility of using it to accelerate scientific experimentation to optimize decisions about which experiments to do next. De Gray cautions that the quality of conclusions from AI depends on the quality and quantity of input data and that the path towards defeating aging would require a symbiotic partnership between humans and AI. Finally, he discusses his excitement about the possibilities of hardware and devices like Apple Watch and Levels in tracking blood sugar levels and their potential to prolong life.