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Category: life extension – Page 158

Man spends millions to attempt to reverse aging

Bryan Johnson, 45, is using his life as a science experiment to see how long he can live and to reverse signs of aging as he goes. NBC News’ Gadi Schwartz reports.

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Oral Microbiome Tests #8 and 9: Serratia marcescens Is Still A Problem

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Continue reading “Oral Microbiome Tests #8 and 9: Serratia marcescens Is Still A Problem” | >

The Promise Of Stem Cells In Aging Research | Dr Elena Seranova Interview Series Ep3

In particular I like the 3D modeling segment.

Here Dr Seranova talks about stem cell use in helping with research into diseases of aging, particularly generating organiods of the brain by growing them from stem cells.
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Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.

Continue reading “The Promise Of Stem Cells In Aging Research | Dr Elena Seranova Interview Series Ep3” | >

Aging Reimagined: How “Immortal” Jellyfish DNA Could Extend Human Life

Two Eötvös Loránd University researchers have made an exciting breakthrough in understanding how we age.

Researchers Dr. Ádám Sturm and Dr. Tibor Vellai from Eötvös Loránd University in Hungary have achieved a significant discovery in the study of aging. Their research centered on “transposable elements” (TEs) in our DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Epigenetic Test #9: Finally, A Younger Horvath Age Than the Chronological

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Discount Links:
Epigenetic, Telomere Testing: https://trudiagnostic.com/?irclickid=U-s3Ii2r7xyIU-LSYLyQdQ6…M0&irgwc=1
Use Code: CONQUERAGING

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Use Code: CONQUERAGING At Checkout.

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Continue reading “Epigenetic Test #9: Finally, A Younger Horvath Age Than the Chronological” | >

Proteins Predict Signs of Alzheimer’s Disease

Protein indicators of subclinical peripheral heath in plasma were linked with markers of Alzheimer’s disease and neurodegeneration, cross-sectional proteomic analyses showed.

Greater protein-based risk for cardiovascular disease, heart failure mortality, and kidney disease was associated with plasma biomarkers of amyloid-beta, phosphorylated tau181 (p-tau181), neurofilament light (NfL, a measure of neuronal injury), and glial fibrillary acidic protein (GFAP, a measure of astrogliosis), even in people without cardiovascular or kidney disease, reported Keenan Walker, PhD, of the National Institute on Aging in Baltimore, and co-authors.

Proteomic indicators of body fat percentage, lean body mass, and visceral fat also were tied to p-tau181, NfL, and GFAP, Walker and colleagues wrote in the Annals of Neurology.

Aging is Now Optional w/ David Sinclair

Advancements in genetic engineering, gene therapies, and anti-aging research may eventually allow for age reversal and the restoration of youthful health and longevity.

What is the key idea of the video?
—The key idea is that advancements in genetic engineering and anti-aging research may eventually allow for age reversal and the restoration of youthful health and longevity.

How can aging be reversed?
—Aging can be reversed through rejuvenating the brain, restoring memories and learning abilities, and addressing the loss of inherited information through genetic engineering and epigenetic reprogramming.

GLS1 inhibitor selectively eliminates senescent cells, ameliorates age-associated disorders

Year 2021 face_with_colon_three

Senescent cells accumulate in organs during aging, promote tissue dysfunction, and cause numerous aging-related diseases like cancer. The cells arise through a process called “cellular senescence,” a permanent cell cycle arrest resulting from multiple stresses.

A collaborative research group led by Professor Makoto Nakanishi of the Institute of Medical Science, The University of Tokyo (IMSUT), and co-researchers have identified an inhibitor of the glutamate metabolic enzyme GLS1so that its administration selectively eliminates senescent cells in vivo.

They confirmed that the GLS1 inhibitor eliminated senescent cells from various organs and tissues in aged mice, ameliorating age-associated tissue dysfunction and the symptoms of obese diabetes, arteriosclerosis, and NASH. The results of this research were published in “Science” on January 15, 2021.

NEW STUDY: Discovery of chemical means to reverse aging and restore cellular function

On July 12, 2023, a new research paper was published in Aging, titled, “Chemically induced reprogramming to reverse cellular aging.”

BUFFALO, NY– July 12, 2023 – In a groundbreaking study, researchers have unlocked a new frontier in the fight against aging and age-related diseases. The study, conducted by a team of scientists at Harvard Medical School, has published the first chemical approach to reprogram cells to a younger state. Previously, this was only achievable using a powerful gene therapy.

On July 12, 2023, researchers Jae-Hyun Yang, Christopher A. Petty, Thomas Dixon-McDougall, Maria Vina Lopez, Alexander Tyshkovskiy, Sun Maybury-Lewis, Xiao Tian, Nabilah Ibrahim, Zhili Chen, Patrick T. Griffin, Matthew Arnold, Jien Li, Oswaldo A. Martinez, Alexander Behn, Ryan Rogers-Hammond, Suzanne Angeli, Vadim N. Gladyshev, and David A. Sinclair from Harvard Medical School, University of Maine and Massachusetts Institute of Technology (MIT) published a new research paper in Aging, titled, “Chemically induced reprogramming to reverse cellular aging.”

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