The discovery that earned Japan’s Shinya Yamanaka the 2012 Nobel Prize in Medicine has paved the way for new research proving that aging is a reversible process. Currently just being tested on lab mice, will the cellular reprogramming soon offer eternal youth?
Preclinical and clinical evidence for exercise as a senescence-targeting therapy and areas needing further investigation are discussed.
(http://www.pharma.unizg.hr/en/about-us/staff/gordan–lauc, 450.html) is Professor of Biochemistry and Molecular Biology at the University of Zagreb, Faculty of Pharmacy and Biochemistry, and Founder and CEO of Genos Ltd. (https://genos-glyco.com/), a research-intensive SME located in Zagreb, Croatia with core of expertise in molecular genetics and glycomics (The comprehensive study the entire complement of sugars, whether free or present in more complex molecules of an organism) and they perform contract research, contract analysis and service for numerous universities, hospitals and private individuals in Europe and overseas.
Prof. Dr. Lauc also is CSO of GlycanAge LTD (https://glycanage.com/), a company that has developed a ground-breaking test that analyses your personal glycobiome for insights in improving your health and monitoring your biological age, and Co-Director of the Human Glycome Project (https://human-glycome.org/).
Ben Goertzel, PhD, is author of many books on artificial intelligence including Ten Years to the Singularity if We Really Really Try; Engineering General Intelligence, Vols. 1 and 2; The Hidden Pattern: A Patternist Philosophy of Mind; and The Path to Posthumanity. He is also editor (with Damien Broderick) of an anthology about parapsychology titled, Evidence for Psi: Thirteen Empirical Research Reports. He is chief scientific officer for Hanson Robotics in Hong Kong.
Here he notes that, while the question of reincarnation in robots seems outlandish, most of our present technology would have seemed nonsensical and incomprehensible to earlier generations of humans. He quotes the 14th Dalai Lama who suggested (half-jokingly) that artificial intelligence programmers of the future might incarnate into robots. He cites Stephen Braude’s book, Immortal Remains, as demonstrating that we must consider some version of consciousness operating outside of the body. He outlines the sort of scientific and metaphysical models that might lead to such a development.
Continue reading “Reincarnation and Robots with Ben Goertzel” »
Occupation-related stress and work characteristics are possible determinants of social inequalities in epigenetic aging but have been little investigated. Here, we investigate the association of several work characteristics with epigenetic age acceleration (AA) biomarkers.
The study population included employed and unemployed men and women (n = 631) from the UK Understanding Society study. We evaluated the association of employment and work characteristics related to job type, job stability; job schedule; autonomy and influence at work; occupational physical activity; and feelings regarding the job with four epigenetic age acceleration biomarkers (Hannum, Horvath, PhenoAge, GrimAge) and pace of aging (DunedinPoAm, DunedinPACE).
We fitted linear regression models, unadjusted and adjusted for established risk factors, and found the following associations for unemployment (years of acceleration): HorvathAA (1.51, 95% CI 0.08, 2.95), GrimAgeAA (1.53, 95% CI 0.16, 2.90) and 3.21 years for PhenoAA (95% CI 0.89, 5.33). Job insecurity increased PhenoAA (1.83, 95% CI 0.003, 3.67), while working at night was associated with an increase of 2.12 years in GrimAgeAA (95% CI 0.69, 3.55). We found effects of unemployment to be stronger in men and effects of night shift work to be stronger in women.
Although my plan is to live forever (or at least, a very long time, societal and natural disasters willing) I know many people in the life-extension community are signed up with a cryonics provider, as a plan B, in case they don’t live long enough to welcome the rejuvenation revolution.
A lot has been written to explain how the people are stored, usually accompanied by a picture of the gleaming liquid nitrogen cooled Dewar flasks, along with the ethical questions of the procedure. However, the journey to the semi-final resting place is often overlooked.
To explore how someone who has signed up to a cryonics program makes that transition, I attended one of the regular cryonics demonstration and training sessions put on by Cryonics UK. It turns out there are 4 key stages in the process – standby, initial cool down, perfusion and transportation.
O.o!!!!
Per a new study, administering the drug rapamycin to mice everyday for the first 45 days of their lives % extends life expectancy by an average 10 percent.
For millennia, scientists and technologists have been scouring the natural world for clues on how to live longer. But is anyone any closer to finally defeating aging?
As the 3rd presenter during the morning session of the American Society for Dermatologic Surgery Meeting, “Emerging Concepts,” Saranya Wyles, MD, PhD, assistant professor of dermatology, pharmacology, and regenerative medicine in the department of dermatology at the Mayo Clinic in Rochester, Minnesota, explored the hallmarks of skin aging, the root cause of aging and why it occurs, and regenerative medicine. Wyles first began with an explanation of how health care is evolving. In 21st-century health care, there has been a shift in how medical professionals think about medicine. Traditionally, the first approach was to fight diseases, such as cancer, inflammatory conditions, or autoimmune disorders. Now, the thought process is changing to a root cause approach with a curative option and how to rebuild health. Considering how to overcome the sequence of the different medications and treatments given to patients is rooted in regenerative medicine principles.
For skin aging, there is a molecular ‘clock’ that bodies follow. Within the clock are periods of genomic instability, telomere attrition, and epigenetic alterations, and Wyles’ lab focuses on cellular senescence.
“We’ve heard a lot at this conference about bio stimulators, aesthetics, and how we can stimulate our internal mechanisms of regeneration. Now, the opposite force of regeneration is the inhibitory aging hallmarks which include cellular senescence. So, what is cell senescence? This is a state that the cell goes into, similar to apoptosis or proliferation, where the cell goes into a cell cycle arrest so instead of dividing apoptosis, leading to cell death, the cell stays in this zombie state,” said Wyles.
