Biotech company Mogling Bio has successfully has completed its first seed investment round with a sole investor, Kizoo Technology Capital.
Mogling Bio is developing new pharmacological approaches to rejuvenate old stem cells of the hematopoietic (blood cell formation) system.
Ageing causes stem cells to lose their normal structure by increased activity of the protein CDC42. Normalising CDC42 activity can restore structure, order and functionality in those aged stem cells.
Turn.bio has announced that its proprietary cellular reprogramming technology was able to significantly increase the proliferative and cytotoxic potential of premanufactured CAR-T cells in vitro.
Turn.bio, a developer of mRNA-based cellular reprogramming technologies, has announced preliminary results from its current trial. The announcement was made by the company’s co-founder, Prof. Vittorio Sebastiano, at the New Frontiers of RNA Nanotherapeutics conference at Houston Methodist Research Institute. These results show that the company’s proprietary Epigenetic Reprogramming of Aging (ERA) technology greatly increases the fitness of CAR-T cells, which are widely used in modern immunotherapy.
The Aging and Drug Discovery Conference (ARDD) 2022 is pleased to present Alex Zhavoronkov from Insilico, with the talk A case study of the application of Pharma. AI platform for discovery and development of dual-purpose therapeutics targeting aging and disease.
Held in Copenhagen at the glorious Ceremonial Hall, this meeting gathers the most prominent figures of the aging and longevity research field, from scientists to clinicians, investors, developers, and everything in between. The fast growth of the conference is evidence of its great quality of it. In 2022 we had around 400 people on-site, and many others joined through the web.
Short clip of Michael Levin, an American developmental and synthetic biologist at Tufts University, talking about Planarian and their capacity to regenerate their organs indefinetely, which makes then biologically immortal.
The remarks where given during a fascinating three-hour-long conversation with Lex Fridman that was aired on october 1st, 2022.
Summary: Researchers have developed a new ophthalmological device that can detect degenerative visual problems such as age-related macular degeneration long before the onset of the first symptoms.
Source: EPFL
Researchers at an EPFL lab have developed an ophthalmological device that can be used to diagnose some degenerative eye disorders long before the onset of the first symptoms. In early clinical trials, the prototype was shown to produce images with a sufficient degree of precision in just five seconds.
When in 2015, Eileen Brown looked at the ETER9 Project (crazy for many, visionary for few) and wrote an interesting article for ZDNET with the title “New social network ETER9 brings AI to your interactions”, it ensured a worldwide projection of something the world was not expecting.
Someone, in a lost world (outside the United States), was risking, with everything he had in his possession (very little or less than nothing), a vision worthy of the American dream. At that time, Facebook was already beginning to annoy the cleaner minds that were looking for a difference and a more innovative world.
Today, after that test bench, we see that Facebook (Meta or whatever) is nothing but an illusion, or, I dare say, a big disappointment. No, no, no! I am not now bad-mouthing Facebook just because I have a project in hand that is seen as a potential competitor.
I was even a big fan of the “original” Facebook; but then I realized, it took me a few years, that Mark Zuckerberg is nothing more than a simple kid, now a man, who against everything and everyone, gave in to whims. Of him, initially, and now, perforce, of what his big investors, deluded by himself, of what his “metaverse” would be.
In the style of Sleeping Beauty, Tardigrades, the adorable, tiny animals that can withstand extreme environments and are also known as “water bears,” can withstand freezing without losing their vitality. Despite harsh environmental conditions, tardigrades are very adaptable. According to Ralph Schill, a professor at the University of Stuttgart, anhydrobiotic (dry) tardigrades can survive for many years without absorbing water. In a frozen state, there was no clear indication of whether aging increased or decreased. It turns out that frozen tardigrades don’t age.
Water bears, also known as tardigrades, are nematodes. They have the same gait as bears, but that’s about the only thing that connects them to bears. As a result of their adaptability to rapidly changing environmental conditions, tardigrades, which are barely one millimeter in size, can freeze in extreme cold and dry out in extreme heat. Rather than dying, Schill explains that they fall into a deep sleep. A cell organism experiences different types of stress when it freezes or dries out. Despite this, tardigrades are equally capable of surviving both extremes of heat and cold. No obvious signs of life can be seen on them. In this state of rest, the animal’s internal clock might be slowed down, which raises the question of whether it ages.
Schill and his team investigated the aging process of dried tardigrades several years ago, which waited in their habitat for rain for many years. Grimm brothers’ fairytales depict a princess who is deeply asleep. A young prince kisses her 100 years later, and she awakes looking as beautiful and young as ever. In a dried state, tardigrades are the same, and therefore this hypothesis is called the “Sleeping Beauty” hypothesis. Schill explains that the internal clock stops during inactivity and resumes once the organism has been reactivated. Accordingly, the researcher explained that tardigrades, whose lifespan usually lasts only a few months without rest, can survive for decades.
Cryo-electron microscopy structures of skeletal F-actin show solvent-driven rearrangements governing actin filament assembly and aging with potential application in design of drugs and small molecules for imaging and therapy.
