Immorta Bio patents a senolytic vaccine that trains the immune system to clear aging cells and weaken tumor growth in early studies.
Category: life extension – Page 11
Speaking Multiple Languages May Slow Brain Aging, Study Suggests
People are living longer than ever around the world. Longer lives bring new opportunities, but they also introduce challenges, especially the risk of age-related decline.
Alongside physical changes such as reduced strength or slower movement, many older adults struggle with memory, attention and everyday tasks.
Researchers have spent years trying to understand why some people stay mentally sharp while others deteriorate more quickly. One idea attracting growing interest is multilingualism, the ability to speak more than one language.
Astrocytic Sox9 overexpression in Alzheimer’s disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function
Researchers at Baylor College of Medicine have discovered a natural mechanism that clears existing amyloid plaques in the brains of mouse models of Alzheimer’s disease and preserves cognitive function. The mechanism involves recruiting brain cells known as astrocytes, star shaped cells in the brain, to remove the toxic amyloid plaques that build up in many Alzheimer’s disease brains. Increasing the production of Sox9, a key protein that regulates astrocyte functions during aging, triggered the astrocytes’ ability to remove amyloid plaques. The study, published in Nature Neuroscience, suggests a potential astrocyte-based therapeutic approach to ameliorate cognitive decline in neurodegenerative disease.
“Astrocytes perform diverse tasks that are essential for normal brain function, including facilitating brain communications and memory storage. As the brain ages, astrocytes show profound functional alterations; however, the role these alterations play in aging and neurodegeneration is not yet understood,” said first author Dr. Dong-Joo Choi, who was at the Center for Cell and Gene Therapy and the Department of Neurosurgery at Baylor while he was working on this project. Choi currently is an assistant professor at the Center for Neuroimmunology and Glial Biology, Institute of Molecular Medicine at the University of Texas Health Science Center at Houston.
Astrocytes are associated with Alzheimer’s disease pathogenesis. We found that the transcription factor Sox9 functions to enhance astrocytic phagocytosis of Aβ plaques via MEGF10, and this clearance of plaques is associated with the preservation of cognitive function in mouse models.
Brain “stars” hold the power to preserve cognitive function in model of Alzheimer’s disease
Researchers at Baylor College of Medicine have discovered a natural mechanism that clears existing amyloid plaques in the brains of mouse models of Alzheimer’s disease and preserves cognitive function. The mechanism involves recruiting brain cells known as astrocytes, star shaped cells in the brain, to remove the toxic amyloid plaques that build up in many Alzheimer’s disease brains. Increasing the production of Sox9, a key protein that regulates astrocyte functions during aging, triggered the astrocytes’ ability to remove amyloid plaques. The study, published in Nature Neuroscience, suggests a potential astrocyte-based therapeutic approach to ameliorate cognitive decline in neurodegenerative disease.
“Astrocytes perform diverse tasks that are essential for normal brain function, including facilitating brain communications and memory storage. As the brain ages, astrocytes show profound functional alterations; however, the role these alterations play in aging and neurodegeneration is not yet understood,” said first author Dr. Dong-Joo Choi, who was at the Center for Cell and Gene Therapy and the Department of Neurosurgery at Baylor while he was working on this project. Choi currently is an assistant professor at the Center for Neuroimmunology and Glial Biology, Institute of Molecular Medicine at the University of Texas Health Science Center at Houston.
Astrocytic Sox9 overexpression in Alzheimer’s disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function.
AI Uncovers Genetic Architecture of the Human Corpus Callosum
The corpus callosum is critical for nearly everything the brain does, from coordinating the movement of our limbs in sync to integrating sights and sounds, to higher-order thinking and decision-making. Abnormalities in its shape and size have long been linked to disorders such as ADHD, bipolar disorder, and Parkinson’s disease. Until now, the genetic underpinnings of this vital structure remained largely unknown.
In the new study, published in Nature Communications, the team analyzed brain scans and genetic data from over 50,000 people, ranging from childhood to late adulthood, with the help of a new tool the team created that leverages artificial intelligence.
“We developed an AI tool that finds the corpus callosum in different types of brain MRI scans and automatically takes its measurements,” said co-first author of the study. Using this tool, the researchers identified dozens of genetic regions that influence the size and thickness of the corpus callosum and its subregions.
The study revealed that different sets of genes govern the area versus the thickness of the corpus callosum—two features that change across the lifespan and play distinct roles in brain function. Several of the implicated genes are active during prenatal brain development, particularly in processes like cell growth, programmed cell death, and the wiring of nerve fibers across hemispheres.
Notably, the study found genetic overlap between the corpus callosum and the cerebral cortex—the outer layer of the brain responsible for memory, attention, and language—as well as with conditions such as ADHD and bipolar disorder.
For the first time, a research team has mapped the genetic architecture of a crucial part of the human brain known as the corpus callosum—the thick band of nerve fibers that connects the brain’s left and right hemispheres. The findings open new pathways for discoveries about mental illness, neurological disorders and other diseases related to defects in this part of the brain.
ENHANCED HUMANS EXIST: How BioViva Is Quietly Upgrading Humanity
Genetic engineering and human enhancement are no longer science fiction — they’re here right now. In this episode of Longevity Science News, we explore the rise of gene therapy, anti-aging biotechnology, and the first wave of GMO Humans using real genetic enhancements to increase muscle, extend telomeres, boost IQ, and slow biological aging.
If you’re interested in longevity, life extension, biohacking, genetic modification, or cutting-edge anti-aging research, this video breaks down everything you need to know about the future of human evolution — and the people already jumping in.
HUME BODY ANALYZER:
Use Code: LONGEVITY for up to 50% OFF
https://humehealth.com//discount/LONG… FEATURED: BioViva Keynote by Liz Parrish Watch the full keynote here: • The First Person to Take Gene Therapy for… This talk covers viral vectors, telomere extension, muscle-growth gene therapies, cognitive enhancement, dementia treatment, and the global expansion of experimental genetic clinics. Chapters: 00:00 – Cold Open — FDA Gene Cures 00:35 – Liz Parrish & BioViva 01:35 – Sebastian A. Brunemeier 02:48 – HUME Body Pod 03:55 – Currently Available Genetic Cures 04:48 – How To Get Access 08:00 – Safety & Pricing 08:22 – Right to Try Debate 09:20 – Follistatin Results 10:50 – Telomere Extension 11:50 – Klotho & IQ Boost 13:26 – IQ & Society 14:35 – Dementia Gene Therapy 15:40 – Custom Therapies 16:20 – Conclusion • FDA-approved genetic cures • BioViva’s gene enhancement results • Follistatin gene therapy for muscle growth • Telomerase (TERT) for biological age reversal • Klotho gene therapy for cognitive enhancement • Dementia gene therapy case studies • Medical tourism for experimental gene treatments • How to access unapproved gene therapies • AI’s role in designing next-gen genetic interventions • Personalized & bespoke gene therapies • Ethical questions about enhancing IQ, strength, and lifespan • The future of human evolution & GMO humans 👤 EXPERTS & SOURCES FEATURED Liz Parrish — BioViva Sciences LinkedIn:
/ lizlparrish Sebastian Brunemeier — Cambrian Bio / Long Game Ventures LinkedIn:
/ sebastianlongbio Long Game Ventures:
/ longgame-vc Wired Magazine — Medical Tourism & Gene Therapy Pricing https://www.wired.com/story/bioviva-g… Extended Interview: Montana Senator Ken Bogner
• Ken Bogner Full Interview 🔗 FULL INTERVIEWS & BONUS CONTENT Get extended conversations, deep dives, and behind-the-scenes research on Patreon: 👉
/ u29506604 💬 JOIN THE DISCUSSION Would you use gene therapy to slow aging? Would you enhance your muscle, intelligence, or longevity? Do you think we should expand access to experimental anti-aging treatments? Let me know in the comments. 🧪 Longevity Science News PRODUCTION CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Executive Producer – Keith Comito @Retromancers Host, Producer, Writer – @emmettshort
🔬 FEATURED: BioViva Keynote by Liz Parrish.
Watch the full keynote here:
• The First Person to Take Gene Therapy for…
This talk covers viral vectors, telomere extension, muscle-growth gene therapies, cognitive enhancement, dementia treatment, and the global expansion of experimental genetic clinics.
Chapters: