Archive for the ‘life extension’ category: Page 11

Nov 10, 2023

Rejuvenation Startup Summit 2024 Announces First Speakers

Posted by in categories: biotech/medical, genetics, life extension

The Rejuvenation Startup Summit (Berlin, May 10–11, 2024) hosted by the Forever Healthy Foundation, is a vibrant networking event that aims to accelerate the development of the rejuvenation biotech industry.

Rejuvenation/longevity biotech is a new, emerging field of medicine. It aims to prevent and reverse diseases of aging by addressing their common root cause, the aging process itself. Rejuvenation therapies aim to reverse or repair age-related cellular changes such as molecular waste, calcification, tissue stiffening, loss of stem cell function, genetic alterations, and impaired energy production.

Nov 10, 2023

Blocking this one protein could strengthen muscles

Posted by in category: life extension

Stanford researchers have finally figured out how a therapy that blocks a single protein can reverse age-related muscle loss in mice — and the discovery suggests seniors might not be the only ones who could benefit from it.

Age-related muscle loss: People tend to start losing muscle mass and strength in their 30s, and from 50 on, you could be losing up to 10% of your muscle mass every decade.

While it is possible to regain lost muscle through exercise, health issues can make hitting the weights a challenge. If left unaddressed, though, age-related muscle loss can lead to decreased mobility and weakness, which increases the risk of falls or other injuries.

Nov 9, 2023

The Kynurenine/Tryptophan Ratio: An Integrated Measure Of Many Pro- And Anti-Inflammatory Factors

Posted by in categories: biotech/medical, genetics, life extension

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Nov 7, 2023

Blocking an aging-related enzyme may restore muscle strength

Posted by in categories: biotech/medical, life extension, neuroscience

Stem cell biologist Helen Blau of Stanford University School of Medicine and colleagues previously found that blocking 15-PGDH in old mice restored their withered muscles and improved their strength after a month of treatment. On the flip side, young mice lost muscle and became weaker after their levels of this enzyme were increased for a month.

Blau’s team has now found that 15-PGDH accumulates in the muscles of old mice as the connections that allow communication between muscles and nerves are lost, another consequence of aging. Treating old mice for one month with a drug that inhibits 15-PGDH restored these connections, called synapses, between muscle fibers and motor nerve cells, and boosted the animals’ strength, the team reports in the Oct. 11 Science Translational Medicine. Those synapses are how the brain directs muscles to move.

The findings suggest that blocking the gerozyme 15-PGDH may be a way to help recover strength that has diminished due to nerve injuries, motor nerve cell diseases or aging.

Nov 7, 2023

Chinese scientists claim to have achieved key anti-aging breakthrough

Posted by in categories: innovation, life extension

Anton Vierietin/iStock.

Another revelation hints at a glimmer of hope.

Nov 7, 2023

15 Best Longevity Books for 2024

Posted by in category: life extension

Looking for some good holiday reads? We’ve updated our list of best longevity books and added several from top longevity researchers like Dr. Harold Katcher, Dr. Morgan Levine, and Dr. Peter Attia.

Update 11/7/2023: This post has been updated since we originally published it in September 2020 and first updated it in April 2021. Several new best longevity books have been added to both the main list and honorable mentions sections, and the post has been cleaned up, and review ratings made current.

There are a lot of life extension and longevity books published every year.

Continue reading “15 Best Longevity Books for 2024” »

Nov 7, 2023

Researchers solve protein mystery

Posted by in categories: biotech/medical, chemistry, life extension

Researchers have uncovered that proteins use a common chemical label as a shield to protect them from degradation, which in turn affects motility and aging. Proteins are key to all processes in our cells and understanding their functions and regulation is of major importance.

“For many years, we have known that nearly all human proteins are modified by a specific chemical group, but its functional impact has remained undefined,” says professor Thomas Arnesen at the Department of Biomedicine, University of Bergen.

Nov 6, 2023

An immune molecule that regulates aging and a living organism’s lifespan

Posted by in categories: biological, life extension

Aging is a natural process that affects all living organisms, prompting gradual changes in their behavior and abilities. Past studies have highlighted several physiological factors that can contribute to aging, including the body’s immune responses, an imbalance between the production of reactive oxygen (i.e., free radicals) and antioxidants, and sleep disturbances.

While the link between aging and these different factors is well-document, the connection between them is still poorly understood. Researchers at Washington University in St. Louis recently identified an immune molecule that could play a key role in modulating the process of aging and the duration living organism’s lifespan.

Their paper, published in Neuron, was inspired by two independent research efforts at the university.

Nov 6, 2023

Cell Death Switch Activates Cancer Death

Posted by in categories: biotech/medical, chemistry, life extension

Scientists from the University of California Davis (UC Davis) Comprehensive Cancer Center have recently published in Cell Death and Disease, identifying a critical protein that causes cells to die. The protein is described as an epitope, which is a section of the protein that is recognized by the immune system to activate a response. This epitope was distinctly found on the CD95 receptor, known to trigger programmed cell death. The report demonstrates a new mechanism to trigger cell death and provide further insight into improved disease treatments.

CD95 receptors, also referred to a “Fas”, are cell death receptors which are present on cell membranes. Once Fas is activated, it generates a signaling cascade which elicits cell death. The mechanism by which cells self-destruct has been an important research topic. By understanding cell death, scientists can generate better therapies for different diseases, including cancer.

Currently, cancer is treated by surgery, chemotherapy, or radiotherapy. Despite initial success, these treatments are unable to fully eradicate tumor cells. Immunotherapy is a new approach to target cancer. Immunotherapy refers to therapeutics modulating the immune system to elicit an effective immune response. This is a more indirect approach compared to lysing tumors with a chemical. One specific immunotherapy referred to as chimeric antigen receptor (CAR) T-cell therapy is a treatment in which T cells, or cytotoxic immune cells, are engineered to lyse tumor cells. Unfortunately, CAR T-cell therapy is limited due to the tumor’s ability to prevent T cell activation.

Nov 6, 2023

Biological age diagnostics

Posted by in categories: biotech/medical, life extension

Two people born on the same day can age very differently.

Biological age diagnostics help pinpoint the rate a person ages regardless of the amount of time they have spent on earth. This could provide earlier detection of disease for personalised preventative strategies.

Our FREE comprehensive market intelligence report demonstrates how biological age diagnostics are radically transforming how we see and tackle aging.

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