Lifeboat Foundation

Billionaires are backing top scientists racing to develop tech that could reverse aging. Cellular reprogramming promises to rejuvenate the body… but how does it work, and is it safe?

00:00 – Introduction.
00:55 – The Role Of Stem Cells.
02:33 – What Is Aging?
03:24 – What Is Cellular Reprogramming?
03:56 – How The Yamanaka Factors Can Rejuvenate Cells.
05:35 – Why Scientists Want To Partially Reprogram Cells.
06:28 – How Humans Could Become More Resilient To Age-Related Diseases.
07:00 – How Johnny Huard Uses Cellular Reprogramming.
08:10 – How Cellular Reprogramming Could Shape The Future.
08:38 – Amazon’s Jeff Bezos Is Investing Billions With Altos Labs.
09:02 – How Harvard Professor David Sinclair Used Cellular Reprogramming on Mice.
10:07 – ChatGPT’s Sam Altman Launched Retro. Biosciences.
10:57 – The Risks of Cellular Reprogramming, Including Cancer.
12:56 – How the Tech World Is Investing In Biotech.
13:50 – Credits.

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Researchers at Duke-NUS Medical School have identified interleukin-11 (IL11) as a key factor in the ageing process. Elevated IL11 levels lead to fat accumulation and muscle loss—two major indicators of ageing. Inhibiting IL11 could enhance healthy lifespans.

Ageing populations pose significant health and economic challenges globally. Even a one-year increase in life expectancy could be valued at $38 trillion.

In a study published in Nature, the team demonstrated that anti-IL11 therapy not only counters the harmful effects of ageing but also increases lifespan by up to 25% in preclinical models. The therapy shifts metabolism from generating harmful white fat to beneficial brown fat, which helps burn calories and maintain body temperature.

Our longevity may actually turn out to have a hard limit. In a new study this week, scientists show that the long rise in our collective life expectancy seen during the 20th century has started to slow down as of late. The findings suggest that focusing on simply expanding our lifespan might be short-sighted, the researchers say.

Abstract Over the course of the twentieth century, human life expectancy at birth rose in high-income nations by approximately 30 years, largely driven by advances in public health and medicine.

In the twentieth century, human life expectancy rose dramatically. Based on the past three decades of observed mortality in the eight countries with the longest-lived populations and in Hong Kong and the United States, Olshansky et al. propose that, without medical breakthroughs that slow aging, radical lifespan extension is implausible in this century.

A drug used to prevent organ rejection in kidney transplant patients is being touted for potentially slowing down aging. Experts comment on the potential benefits and the need for more research.

The German scientist argues that information cannot be destroyed and, in principle, it is possible that a higher being, one day, in some way, could reassemble it and bring it back to life.

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In most vertebrates, a pattern of chemical marks on the genome is a reliable indicator of age, but in axolotls this clock seems to stop after the first four years of life.

By Claire Ainsworth

Last week we reported that The Cat Health Company had closed its pre-seed round and is now moving towards identifying and developing new therapeutics for age-related diseases in cats. As the pet longevity field continues to gather momentum, The Cat Health Company aims to join companies like Loyal and Arterra at the forefront of this movement. Founded by Alex Bacita and Alex Voda, the Bucharest-based company is not only focused on improving the lifespan of our feline friends but also on enhancing their overall quality of life by targeting the underlying mechanisms of aging.

Longevity. Technology: Pet longevity is becoming a growing area of interest for both researchers and consumers; as owners increasingly seek solutions to extend the healthspan of their pets, demand for scientifically backed innovations has grown, and it is a trend that mirrors the rising popularity of similar human-focused longevity research, signaling a shift in how we approach aging across species.

We sat down with Alex Voda, cofounder of The Cat Health Company, to discuss the future of feline longevity and how TCHC plans to turn cutting-edge research into practical treatments for the cats we cherish.