Lifeboat Foundation

Researchers have launched an ultra-large virtual docking library expected to grow to more than 1 billion molecules by next year. It will expand by 1000-fold the number of such “make-on-demand” compounds readily available to scientists for chemical biology and drug discovery. The larger the library, the better its odds of weeding out inactive “decoy” molecules that could otherwise lead researchers down blind alleys. The project is funded by the National Institutes of Health.

“To improve medications for mental illnesses, we need to screen huge numbers of potentially therapeutic molecules,” explained Joshua A. Gordon, M.D., Ph.D., director of NIH’s National Institute of Mental Health (NIMH), which co-funded the research. “Unbiased computational modeling allows us to do this in a computer, vastly expediting the process of discovering new treatments. It enables researchers to virtually “see” a molecule docking with its receptor protein—like a ship in its harbor berth or a key in its lock—and predict its pharmacological properties, based on how the molecular structures are predicted to interact. Only those relatively few candidate molecules that best match the target profile on the computer need to be physically made and tested in a wet lab.”

Bryan Roth, M.D., Ph.D., of the University of North Carolina (UNC) Chapel Hill, Brian Shoichet, Ph.D., and John Irwin, Ph.D., of the University of California San Francisco, and colleagues, report on their findings Feb. 6, 2019 in the journal Nature. The study was supported, in part, by grants from NIMH, National Institute of General Medical Sciences (NIGMS), the NIH Common Fund, and National Institute of Neurological Disorders and Stroke (NINDS).

Perfectionism often develops in childhood, is impacted by parenting and can lead to mental health struggles in later life. Credit: Shutterstock We recently conducted one of the largest-ever studies on perfectionism. We learned that perfectionism has increased substantially over the past 25 years and that it affects men and women equally.

We also learned that perfectionists become more neurotic and less conscientious as time passes.

Perfectionism involves striving for flawlessness and requiring perfection of oneself and others. Extremely negative reactions to mistakes, harsh self-criticism, nagging doubt about performance abilities and a strong sense that others are critical and demanding also define the trait.

Continue reading “Young people drowning in a rising tide of perfectionism” »

Very excited to have interviewed Dr. Michael Lustgarten in my role as longevity / aging ambassador for the ideaXme Show — Mike has been at the forefront of studying the 100 trillion organisms present in the human microbiome, their effect on human health and wellness, as well as a major proponent of metabolomics and biologic age tracking — A true future thinker in the area of extending human lifespan and healthspan

Women’s Brains Age More Slowly Than Men’s : Shots — Health News Researchers say the metabolism of a woman’s brain remains higher than a man’s throughout a lifetime. And that may help with late-life creativity and learning.

Diagnosed cases of autism spectrum disorder (ASD) in California rose by 600 percent from 1990 to 2003. Irva Hertz-Picciotto, Ph.D., director of the Environmental Health Sciences Core Center at the University of California-Davis, published this statistic in the journal Epidemiology a decade ago.

The esteemed epidemiologist told the audience during the Jan. 8 NIEHS Distinguished Lecture that she and her colleagues have only been able to explain a third of the increase.

“No single factor accounts for all autism cases, nor is there one event or exposure that can be responsible for the rapid increase in diagnoses,” said Hertz-Picciotto. “Each child’s path to altered brain development may be different.” Her talk was hosted by NIEHS and National Toxicology Program (NTP) Director Linda Birnbaum, Ph.D.

Continue reading “Autism spectrum disorders may stem from multiple factors” »

Commentary

The crime scene was straight out of an Alfred Hitchcock movie. One hundred and fifty dead birds lay sprawled on the ground, fallen out of trees in a park in The Hague, The Netherlands.

The second such occurrence last autumn made Dutch citizens look up and wonder. With robust starlings turned upside-down at their feet, the usual suspects of disease, pollution, and foul play were dismissed.

Continue reading “The Threat 5G Poses to Human Health” »

CRISPR And Human Embryo Experiments Underway In The U.S. : Shots — Health News Despite outrage over gene editing in China that affected the birth of twins, research is underway in the U.S. to assess the safety and effectiveness of CRISPR tools to edit genes in human embryos.

As important as sleep is for health, happiness, and performance, it really is a time suck. Those eight or so hours when we lose consciousness may be restorative, but just think of what we could accomplish if we could actually put them to productive use. Scientists believe that we can use these unconscious hours to begin to learn new facts or languages in our sleep, as long the information is presented in the right way.

In his paper published Thursday in Current Biology, University of Bern neuropsychologist Marc Züst, Ph.D., presents evidence that it’s actually possible to form new “semantic connections” at specific moments during the sleep cycle. These, he explains, are associations between two words that we use to help encode new information and give words context. For instance, when we hear the word “winter,” we think of cold temperatures, skiing, or, most recently, polar vortices. In his study, Züst found that the brain can actually learn to make these associations if we hear two words paired together at certain times within the sleep cycle.

“Humans are capable of sophisticated information processing without consciousness,” Züst tells Inverse. “Sleep-formed memory traces endure into the following wakefulness and can influence how you react to foreign words, even though you think you’ve never seen that word before. It’s an implicit, unconscious form of memory — like a gut feeling.”

Continue reading “Learning Language in Deep Sleep Isn’t Just Science Fiction Anymore” »

The bacteria that live in our bodies have a pivotal role in the maintenance of our health, and can influence a range of conditions, such as obesity and cancer. Perhaps the most important role for the community of microorganisms that live in our gut — termed the microbiota, which include bacteria, fungi and archaea — is to aid immune-system development. Writing in Nature, Tanoue et al. report the identification of 11 strains of bacteria that reside in the guts of some healthy humans and that can boost immune responses that fight infection and cancer.

Microorganisms in the human gut can affect immune-system cells. Gut bacterial strains have been discovered that boost immune cells that have cell-killing capacity and that can target cancer and protect against infection. Human gut bacteria boost immune cells that have cell-killing capacity.