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Category: health – Page 2

New aortic repair device improves patient survival and recovery

King George, Albert Einstein, John Ritter, Richard Holbrooke, George C Scott, Lucille Ball, Betty Garrett, Walter Huston, Humphrey Lyttleton, Marilyn Chambers, and Michael Rennie all died from the same thing, Aortic dissection however the FDA recently approved AMDS Hybrid Prosthesis is helping change that by greatly inproving survival and recovery rates. UI Health Care is the first in Iowa to implant a patient with the recently approved AMDS Hybrid Prosthesis.

Patients who experience a specific type of aortic tear now have a new treatment option available at UI Health Care. The AMDS Hybrid Prosthesis, the world’s first aortic arch remodeling device, was recently approved for DeBakey Type 1 aortic dissection patients.

DeBakey Type 1 aortic dissection is a tear in the inner layer of the wall of the aorta—the main artery that carries oxygen-rich blood to the rest of the body. An aortic dissection causes blood to flow between the wall layers, which slows or stops normal blood flow and can lead to a complete rupture of the aorta. The condition is emergent, life-threatening, and requires immediate surgical repair.

The current treatment option involves removing a portion of the damaged aorta and grafting a synthetic tube in its place. These procedures are successful but often fail to treat the remainder of the diseased aorta, which can result in complications and the need for additional procedures in the future.

New study links blood proteins to Alzheimer’s disease and memory loss

Researchers at Emory Goizueta Brain Health Institute and partner institutions have found new clues in the blood that could help explain why Alzheimer’s disease develops and how it affects memory.

The study, published in Nature Aging, examined from more than 2,100 individuals across four large research cohorts. Using advanced tools, scientists measured thousands of proteins in the blood and linked them to changes in the and thinking ability.

Traditionally, doctors have focused on sticky amyloid plaques in the brain as a hallmark of Alzheimer’s.

Soft magnetoelastic sensor measures fatigue from eyeball movements in real-time

Over the past few decades, electronics engineers have developed increasingly sophisticated sensors that can reliably measure a wide range of physiological signals, including heart rate, blood pressure, respiration rate and oxygen saturation. These sensors were used to create both biomedical and consumer-facing wearable devices, advancing research and the real-time monitoring of health-related metrics, such as sleep quality and physiological stress.

Fatigue, a mental state marked by a decline in performance due to stress, lack of sleep, excessive activity or other factors, has proved to be more difficult to reliably quantify. Most existing methods for measuring fatigue rely on surveys that ask people to report how tired they feel, a method to record the brain’s electrical activity known as electroencephalography (EEG) or camera-based systems.

Most of these approaches are unreliable or only applicable in laboratory settings, as they rely on subjective evaluations, bulky equipment or controlled environments. These limitations prevent their large-scale deployment in everyday settings.

Atom-thin crystals provide new way to power the future of computer memory

Picture the smartphone in your pocket, the data centers powering artificial intelligence, or the wearable health monitors that track your heartbeat. All of them rely on energy-hungry memory chips to store and process information. As demand for computing resources continues to soar, so does the need for memory devices that are smaller, faster, and far more efficient.

A new study by Auburn physicists has taken an important step toward meeting this challenge.

The study, “Electrode-Assisted Switching in Memristors Based on Single-Crystal Transition Metal Dichalcogenides,” published in ACS Applied Materials & Interfaces, shows how memristors—ultra-thin that “remember” past —switch their state with the help of electrodes and subtle atomic changes inside the material.

World’s First Clinical Trial Showing Lubiprostone AIDS Kidney Function

Chronic kidney disease (CKD) is a major health issue worldwide. Many patients end up requiring regular dialysis to avoid kidney failure and stay alive. Despite the severity of the condition, there are currently no drugs available that improve kidney function. A research group led by Tohoku University Graduate School of Medicine’s Professor Takaaki Abe has found a remarkable solution to treat patients with CKD by co-opting a drug typically used for constipation. This is the first time that this drug (lubiprostone) was shown to prevent the decline of renal function in patients with CKD.

“We noticed that constipation is a symptom that often accompanies CKD, and decided to investigate this link further,” explains Abe. “Essentially, constipation disrupts the intestinal microbiota, which worsens kidney function. Working backwards, we hypothesized that we could improve kidney function by treating constipation.”

To address this issue, the group conducted a multicenter Phase II clinical trial (LUBI-CKD TRIAL) at nine Japanese medical institutions, enrolling 150 patients with moderate CKD. This study evaluated the effects of lubiprostone on kidney function. The results showed that, compared to the placebo group, the decline in kidney function (defined as the estimated glomerular filtration rate: eGFR) was suppressed in a dose-dependent manner in patients treated with 8 µg or 16 µg of lubiprostone.

A drug called lubiprostone — typically used for constipation — was remarkably shown to help patients with chronic kidney disease.

Surprising gut discovery reveals a hidden trigger of diabetes and liver disease

Scientists in Canada have uncovered a surprising culprit behind high blood sugar and liver problems: a hidden fuel made by gut bacteria. This little-known molecule, called D-lactate, slips into the bloodstream and pushes the liver to make too much sugar and fat. By creating a simple “trap” that blocks the molecule in the gut, researchers saw big improvements in blood sugar, insulin resistance, and liver health in obese mice—without changing diet or weight. The discovery opens up a fresh way to fight diabetes and fatty liver disease by targeting the gut’s secret fuel before it can do harm.

Personalized brain stimulation shows benefit for depression

A more precise and personalized form of electric brain stimulation may be a more effective and faster treatment for people with moderate to major depression compared to other similar treatments, according to a UCLA Health study.

The study, published in JAMA Network Open, examined the effectiveness of a noninvasive brain stimulation treatment known as (HD-tDCS) in treating depression. Transcranial direct current stimulation uses electrodes placed on a patient’s scalp to deliver noninvasive, safe levels of electrical currents to targeted areas of the brain.

For depression, the treatment is used to target brain networks that regulate emotional processing and self-referential thoughts. TDCS has not been approved by the U.S. Food and Drug Administration as a treatment for depression, and into various forms of tDCS is ongoing.

In quantum sensing, what beats beating noise? Meeting noise halfway

Noise is annoying, whether you’re trying to sleep or exploit the laws of quantum physics. Although noise from environmental disturbances will always be with us, a team including scientists at the National Institute of Standards and Technology (NIST) may have found a new way of dealing with it at the microscopic scales where quantum physics reigns. Addressing this noise could make possible the best sensors ever made, with applications ranging from health care to mineral exploration.

By taking advantage of quantum phenomena known as superposition and entanglement, researchers can measure subtle changes in the environment useful for everything from geology to GPS. But to do this, they must be able to see through the caused by environmental sources such as stray magnetic fields to detect, for example, an important signal from the brain.

New findings, detailed today in Physical Review Letters, would enable interlinked groups of quantum objects such as atoms to better sense the environment in the presence of noise. A horde of unlinked quantum objects can already outperform a conventional sensor. Linking them through the process of quantum entanglement can make them perform better still. However, entangling the group can make it vulnerable to environmental noise that causes errors, making the group lose its additional sensing advantage.

Dr. Michael Lebenstein-Gumovski, Ph.D. — Spinal Cord Restoration, Head Transplants & Beyond

Spinal Cord Restoration, Head Transplants & Beyond — The Rise And Future Of Transplantation Neurosurgery — Dr. Michael Lebenstein-Gumovski, Ph.D. — Senior Scientific Officer, Sklifosovsky Emergency Medicine Institute, Moscow, Russian Federation

Dr. Michael Lebenstein-Gumovski, Ph.D. is Senior Scientific Officer and Neurosurgeon, in the Neurosurgery Department, of the Sklifosovsky Clinical and Research Institute for Emergency Medicine, Moscow, Russian Federation (https://sklif.mos.ru/), where his team is engaged in both neurosurgical and experimental practice, conducting advanced research in the field of spinal cord injury restoration, spinal cord transplantation and head transplantation.

The Sklifosovsky Institute for Emergency Medicine is a large multidisciplinary scientific and practical center dealing with problems of emergency medical care, emergency surgery, resuscitation, combined and burn trauma, emergency cardiology and acute poisoning.

Since 2013, Dr. Lebenstein-Gumovski has been studying spinal cord injury, and also developing methods for restoring the full functional and morphological repair of the spinal cord.

Dr. Lebenstein-Gumovski’s work is aimed at studying the effect of fusogens on nervous tissue, developing new methods and techniques for treating spinal cord injury, developing methods for its resection and transplantation. The lab develops and studies various methods of neuroprotection, combining methods to achieve better results and the current focus is the study of combination fusogen-induced (PEG-chitosan, Neuro-PEG) axonal restoration of the spinal cord after its complete transection.

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Viral mechanism behind nasopharyngeal cancer spread

Lymphoid structures and thermogenic adipose tissue interplay!

The presence of active thermogenic adipose tissue (TAT) has been related to better cardiometabolic health.

While immunity and metabolism were once considered distinct domains, emerging evidence highlights the critical role of infiltrated immune cells in orchestrating the development and activation of TAT. Despite this novel function of infiltrated immune cells, scarce research has focused on the role that organized lymphoid structures like lymph nodes (LNs) and lymphatics exert on TAT metabolism.

The presence of peripheral LNs relates to a higher browning and thermogenic capacity of the surrounding fat, at least in part, through the secretion of factors like IL-33 and CCL22, and the higher number of BST2-beige adipocyte progenitors compared to more distant fat.

The lymphatic vasculature also influences TAT function and adaptive thermogenesis through the secretion of neurotensin by the lymphatic endothelial cells.

Future research should elucidate whether exploiting the lymphoid tissue– TAT axis could constitute a potential therapeutic target to activate TAT. #sciencenewshighlights #ScienceMission https://sciencemission.com/lymphoid-structures-and-thermogenic-adipose-tissue

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