Changes in the heart might mean more than just cardiovascular risk – they could also signal early shifts in brain health.
A large meta-analysis found that even subtle heart problems, like issues with how the heart pumps or relaxes, are linked to smaller brain volumes, particularly in areas related to memory.
Heart Issues May Signal Early Dementia Risk.
Every year, millions of tires end up in landfills, creating an environmental crisis with far-reaching consequences. In the United States alone, over 274 million tires were scrapped in 2021, with nearly 20% of them being discarded in landfills. The accumulation of these waste materials presents not only a space issue but also introduces environmental hazards, such as chemical leaching and spontaneous combustion.
While pyrolysis—a process that chemically recycles rubber through high-temperature decomposition—is widely used, it generates harmful byproducts like benzene and dioxins, posing health and environmental risks.
A study titled “Deconstruction of Rubber via C–H Amination and Aza-Cope Rearrangement,” published in Nature, introduces a novel chemical method for breaking down rubber waste. This technique utilizes C–H amination and a polymer rearrangement strategy to transform discarded rubber into valuable precursors for epoxy resins, offering an innovative and sustainable alternative to traditional recycling methods.
NASA’s Parker Solar Probe just screamed past the Sun for the 23rd time, once again matching its own records for closest approach and fastest human-made object. Zooming through space at 430,000 mph and skimming just 3.8 million miles from the solar surface, the probe is in perfect health and sendi
To prevent similar incidents from reoccurring in the future, Cloudflare has improved credential logging and verification and now mandates the use of automated deployment tooling to avoid human errors.
The company is also updating standard operating procedures (SOPs) to require dual validation for high-impact actions like credential rotation and plans to enhance health checks for faster root cause detection.
Cloudflare’s R2 service suffered another 1-hour long outage in February, which was also caused by a human error.
The University of Cincinnati is leading public urban universities into a new era of innovation and impact. Our faculty, staff and students are saving lives, changing outcomes and bending the future in our city’s direction. Next Lives Here.
Study coauthors include UC’s Sreekar Puchala and Anca Ralescu and Ethan Muchnik of the University of Oregon. The study authors declare no competing interests.
This work was supported by the Office of the Assistant Secretary of Defense for Health Affairs, through the Defense Medical Research and Development Program under Award No. W81XWH-16–2–0020. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense.
A breathable cardiac electronic skin possesses ICU-grade accuracy, outstanding stability, and biocompatibility.
The researchers turned to a group of molecules called acylcarnitines, which are associated with declining cognition and breaking down or metabolizing fats and proteins for energy. To test if high acylcarnitine levels in the blood could predict who’s at risk of developing Alzheimer’s, the researchers used data from a large-scale study called the Alzheimer’s Disease Neuroimaging Initiative.
“It was fascinating,” the author said. “Dividing research participants into groups based on their specific acylcarnitine levels highlighted people with more severe Alzheimer’s disease and others with fewer symptoms.” This led the researchers to define a bioenergetic clock based on acylcarnitines—how old a person’s metabolism acts, compared to actual age. Higher bioenergetic age is linked to higher acylcarnitine levels, worsened Alzheimer’s pathology, cognitive decline and brain atrophy.
The researchers also quantified cognitive decline using a common test called the mini-mental state examination, on which a score below 24 out of 30 points indicates impairment. They found that people with low acylcarnitine levels to begin with declined more slowly, losing about 0.5 points less per year than people with high acylcarnitine levels. The benefit is on par with the Alzheimer’s drug lecanemab.
To some degree, a person’s bioenergetic clock ticks forward at a rate determined by their genetics, but having a healthy lifestyle—for example, eating a plant-based diet and exercising —can help keep acylcarnitine levels low, which means a younger bioenergetic age, the author explained.
They went on to identify a subgroup of participants, about 30% of the Alzheimer’s Disease Neuroimaging Initiative, with older bioenergetic age but favorable genetic background. These individuals may benefit more from early lifestyle interventions designed to decrease their bioenergetic age and potentially delay or prevent the onset of Alzheimer’s.
Moving forward, the senior author hopes to home in on the lifestyle interventions most effective for lowering bioenergetic age. For example, eating a low-carb diet may help maintain metabolic health, but just how low would carbohydrate consumption have to be for a person to see benefits?
TOKYO (Kyodo) — Thirty years after the deadly sarin nerve gas attack on the Tokyo subway system, some survivors are still suffering debilitating afte
Genomic variation accounts for some of the differences among people, including important aspects of their health and susceptibility to diseases.
Proximity of WUI fires leads to disproportionately large impacts on air quality and human health especially for urban population.
