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The Covid omicron XBB.1.5 variant is rapidly becoming dominant in the U.S. because it is highly immune evasive and appears more effective at binding to cells than related subvariants, scientists say.

XBB.1.5 now represents about 41% of new cases nationwide in the U.S., nearly doubling in prevalence over the past week, according to the data published Friday by the Centers for Disease Control and Prevention. The subvariant more than doubled as a share of cases every week through Dec. 24. In the past week, it nearly doubled from 21.7% prevalence.

Scientists and public health officials have been closely monitoring the XBB subvariant family for months because the strains have many mutations that could render the Covid-19 vaccines, including the omicron boosters, less effective and cause even more breakthrough infections.

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In a recent study published in Cell, researchers used a multi-omics approach to profile the gut microbiomes and metabolomes of mothers and infants to determine the vertical and horizontal transmission of bacterial species and strains as well as individual genes and understand the dynamics of the gut microbiome assembly that shape the development of the infant before and after birth.

The vertical transmission of gut bacteria from mother to fetus during pregnancy and the horizontal transfer of microbes through breast milk plays a vital role in the physical and cognitive development of the infant long after birth. Studies have shown associations between the gut microbiota composition of breastmilk and the development of the infant’s immune system, as well as autoimmune conditions and allergies. Furthermore, allergies and autoimmune disorders have also been linked to exogenous proteins in infant formula.

Metabolites produced by gut microbiota are also associated with the infant’s cognitive development. However, the development of gut microbiomes and metabolomes in the perinatal stage and their role in infant development remains unclear.

Although the toxicity of graphene‐based nanomaterials on human health has been extensively studied, their impact on the microbiome remains poorly understood. Using zebrafish as a model, we show that graphene oxide modulates the immune system in a microbiome‐dependent manner through a mechanism mediated by the aryl hydrocarbon receptor. The study suggests an interplay among graphene‐based nanomaterials, microbiome and innate immune system.

Scientists have discovered that an inflammatory cytokine known as LIGHT is a major factor in the deadly airway damage that can affect people with severe asthma. This research has suggested that such airway damage could be reversed by therapeutics that halt LIGHT, and the molecule could offer a way to treat asthma. The study, which used a mouse model and human tissue, has been reported in the Journal of Allergy and Clinical Immunology.

“This is a very, very significant finding,” said senior study author and LJI Professor Michael Croft, Ph.D. “This research gives us a better understanding of the potential of therapeutic targeting of LIGHT and what we might do to relieve some of the symptoms and some of the inflammatory features seen in patients who have severe asthma.”

Immunotherapy is a type of drug that might be an option if you have triple-negative breast cancer.

Triple-negative breast cancer, also called basal-like breast cancer, is not sensitive to hormones. This means that the breast cancer cells don’t use estrogen or progesterone to grow and they don’t have hormone receptors. This type of breast cancer also doesn’t produce too much of the growth-promoting protein called HER2.

“Triple-negative breast cancer is about 10% to 15% of all breast cancer cases,” says Pooja Advani, M.D., a medical oncologist with the Robert and Monica Jacoby Center for Breast Health at Mayo Clinic in Florida.