Lifeboat Foundation

A new study published in Nature Cell Biology by Mark Alkema, PhD, professor of neurobiology, establishes an important molecular link between specific B12-producing bacteria in the gut of the roundworm C. elegans and the production of acetylcholine, a neurotransmitter important to memory and cognitive function.

There is growing recognition among scientists that diet and gut microbiota may play an important role in brain health. Changes in the composition of the microbiome have been linked to neurological disorders such as anxiety, depression, migraines and neurodegeneration. Yet, teasing out the cause and effect of individual bacteria or nutrients on brain function has been challenging.

“There are more bacteria in your intestine than you have cells in your body,” said Woo Kyu Kang, PhD, a postdoctoral fellow in the Alkema lab and first author of the current study. “The complexity of the brain, the hundreds of bacterial species that comprise the gut microbiome and the diversity of metabolites make it almost impossible to discern how bacteria impact brain function.”

Diverse gut microbiomes protect against pathogens by blocking nutrient access, according to a new Science study. The findings highlight why microbiome diversity is important to human health.

While dementia is much more common in older adults, hundreds of thousands of people are diagnosed with young-onset dementia (YOD) each year – and an extensive new study sheds some considerable new light on why.

Most previous research in this area has looked at genetics passed down through generations, but here, the team was able to identify 15 different lifestyle and health factors that are associated with YOD risk.

“This is the largest and most robust study of its kind ever conducted,” says epidemiologist David Llewellyn from the University of Exeter in the UK.

YSM researchers are using deeplearning AI models to improve detection of patients at risk for multiple hospitalizations due to asthma and COPD.

Asthma and chronic obstructive pulmonary disease (COPD) are two of the most common lung diseases worldwide, and exacerbation of these conditions can negatively impact health and increase health care costs. A new study shows that deep learning, a type of artificial intelligence (AI) that uses large amounts of data to process information, can improve detection of patients with these diseases who are at increased risk for multiple hospitalizations.

The study was published Dec. 13, 2023, in the journal Respiratory Research.

Continue reading “Using AI to Identify High Risk Patients With Asthma and COPD” »

Our smart devices take voice commands from us, check our heartbeats, track our sleep, translate text, send us reminders, capture photos and movies, and let us talk to family and friends continents away.

Now imagine turbocharging those capabilities. Holding in-depth, natural language exchanges on academic or personal queries; running our vital signs through a global database to check on imminent health issues; packing massive databases to provide comprehensive real-time translation among two or more parties speaking different languages; and conversing with GPS software providing details on the best burgers, movies, hotels or people-watching spots trending along your route.

Tapping into the seductive power of large language models and natural language processing, we’ve witnessed tremendous progress in communications between us and technology that we increasingly rely on in our daily lives.

Hmmm I wonder if this can lead to allergies and inflammation. I googled it. Yes it can lead to allergies. Maybe that’s why I can’t drink coffee anymore or Earl Grey Tea. Another Google search says it can lead to inflammation which causes a lot of health problems.

You may think that artificial sweeteners can help you lose some weight, but a new study finds they are no good for your gut’s microbiome.

People who use aspartame (Equal), sucralose (Splenda), saccharin (Sweet’N Low), or stevia leaf extract tended to have intestinal bacteria colonies that differed significantly from those of people who didn’t use sugar substitutes, researchers found.

Continue reading “Could artificial sweeteners alter your microbiome?” »

Dementia and stroke often have devastating consequences, so patients want to know what they can do to protect themselves against these diseases. A team of clinicians in partnership with patients developed a Brain Care Score (BCS) based on modifiable risk factors identified in past epidemiological studies. In the BCS, weights are assigned to four physical components (i.e., blood pressure, glycosylated hemoglobin, cholesterol, and body-mass index), to five lifestyle elements (i.e., nutrition, alcohol intake, smoking, aerobic activities, and sleep), and to three social factors (i.e., stress, relationships, and purpose in life). Lower scores on the BCS (range, 0–19) predict higher risk.

The team then validated whether the BCS predicted new dementia or stroke in the U.K. Biobank cohort, which consisted of 398,900 people (age range at baseline, 40–69). During average follow-up of nearly 13 years, new dementia or stroke occurred in ≈3% of the cohort. The BCS identified people who were at highest risk for these outcomes. For example, among those who were younger than 50 at baseline, a 5-point higher score predicted 59% lower risk for dementia and 48% lower risk for stroke.

This score could be computed automatically from information already in electronic health records and used to identify risk factors and to engage patients in modifying those risk factors. Whether such scoring would actually lead to lower incidences of dementia and stroke remains to be seen.

Edwin Ostrin, M.D., Ph.D., discusses the ongoing research into whether vaping is linked to lung cancer and other lung health issues.

A new study shows that cannabis can make exercise more enjoyable, but also more effortful, depending on the type and the person.