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Developing Novel DNA-Based Mechano-Technologies For Human Health — Dr. Khalid Salaita, Ph.D. — Emory University


Dr. Khalid Salaita, Ph.D. (https://www.salaitalab.com/salaita) is a Professor of Chemistry at Emory University in Atlanta, Georgia (USA), program faculty in the Department of Biomedical Engineering at Georgia Tech and Emory, program member of Cancer Cell Biology at Winship Cancer Institute, and most recently is the recent winner Future Insight Prize given by Merck KGaA, Darmstadt, Germany (https://www.emdgroup.com/en/research/open-innovation/futurei…aming.html) for his cutting edge work in the area of mechanobiology.

Dr. Salaita earned his B.S. in Chemistry, from Old Dominion University, his Ph.D. in Chemistry from Northwestern University, completed a postdoctoral fellowship in the Department of Chemistry at the University of California, Berkeley, and then started his own lab at Emory University, investigating the interface between living systems and engineered nanoscale materials. To achieve this goal, his group has pioneered the development of tools like molecular force sensors, DNA mechano-technology, smart therapeutics, and nanoscale mechanical actuators to help manipulate living cells.

Michael Shiloh had been studying tuberculosis for about two decades when he started wondering about a seemingly basic question: What makes people with TB cough? This is the disease’s hallmark symptom and a main mode of transmission, but despite training as an infectious disease physician and many years of probing the pathogen as a researcher, Shiloh realized that he didn’t know. A quick search of the literature suggested that “essentially nothing had been studied about it, at least not at the molecular level,” he says.

Elucidating the role of cough in illness means first appreciating its role in health. “Cough is one of these critical defensive processes that we have to clear the respiratory system,” says Stuart Mazzone, a neuroscientist at the University of Melbourne. But it also contributes to disease spread, as research by Shiloh, now at the University of Texas Southwestern Medical Center, and others has described. And dysfunctional control of coughing — resulting in too much coughing or not enough — can cause serious health problems.

Here’s a look at how and why we cough, and some of the ways that coughing can go wrong.

Working on your muscles could help delay the onset of Alzheimer’s symptoms, researchers have revealed.

Researchers from the Federal University of São Paulo and the University of São Paulo in Brazil have uncovered strong evidence that resistance training – where muscles are worked against a weight or a force – could have significant consequences for the brains of dementia patients.

Before you hurriedly renew your gym membership or break out the home exercise equipment, it’s worth bearing in mind that this was a mouse model study. Nevertheless, the same principles are likely to apply to humans.

A new study by researchers at the University of Cambridge reveals a surprising discovery that could transform the future of electrochemical devices. The findings offer new opportunities for the development of advanced materials and improved performance in fields such as energy storage, brain-like computing, and bioelectronics.

Electrochemical devices rely on the movement of charged particles, both ions and electrons, to function properly. However, understanding how these charged particles move together has presented a significant challenge, hindering progress in creating new materials for these devices.

In the rapidly evolving field of bioelectronics, soft conductive materials known as conjugated polymers are used for developing that can be used outside of traditional clinical settings. For example, this type of materials can be used to make wearable sensors that monitor patients’ health remotely or implantable devices that actively treat disease.

More cases of locally acquired malaria have been detected in the United States, bringing the total up to seven across the country.

In a recent report, Florida health officials said they detected two more cases of the mosquito-borne illness in Sarasota County.

It comes just two weeks after four people in Sarasota County and one person in Cameron County, Texas, were found to have malaria.

Gas accidents such as toxic gas leakage in factories, carbon monoxide leakage of boilers, or toxic gas suffocation during manhole cleaning continue to claim lives and cause injuries. Developing a sensor that can quickly detect toxic gases or biochemicals is still an important issue in public health, environmental monitoring, and military sectors. Recently, a research team at POSTECH has developed an inexpensive, ultra-compact wearable hologram sensor that immediately notifies the user of volatile gas detection.


[Professor Junsuk Rho’s research team at POSTECH develops wearable gas sensors that display instantaneous visual holographic alarm.].

Artificial intelligence algorithms, such as the sophisticated natural language processor ChatGPT, are raising hopes, eyebrows and alarm bells in multiple industries. A deluge of news articles and opinion pieces, reflecting both concerns about and promises of the rapidly advancing field, often note AI’s potential to spread misinformation and replace human workers on a massive scale. According to Jonathan Chen, MD, PhD, assistant professor of medicine, the speculation about large-scale disruptions has a kernel of truth to it, but it misses another element when it comes to health care: AI will bring benefits to both patients and providers.

Chen discussed the challenges with and potential for AI in health care in a commentary published in JAMA on April 28. In this Q&A, he expands on how he sees AI integrating into health care.

The algorithms we’re seeing emerge have really popped open Pandora’s box and, ready or not, AI will substantially change the way physicians work and the way patients interact with clinical medicine. For example, we can tell our patients that they should not be using these tools for medical advice or self-diagnosis, but we know that thousands, if not millions, of people are already doing it — typing in symptoms and asking the models what might be ailing them.

BERLIN — A United Nations technology agency assembled a group of robots that physically resembled humans at a news conference Friday, inviting reporters to ask them questions in an event meant to spark discussion about the future of artificial intelligence.

The nine robots were seated and posed upright along with some of the people who helped make them at a podium in a Geneva conference center for what the U.N.’s International Telecommunication Union billed as the world’s first news conference featuring humanoid social robots.

Among them: Sophia, the first robot innovation ambassador for the U.N. Development Program, or UNDP; Grace, described as a health care robot; and Desdemona, a rock star robot. Two, Geminoid and Nadine, resembled their makers.