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Bonn researchers identify protein that increases the formation of good brown and beige fat. Brown fat cells convert energy into heat — a key to eliminating unwanted fat deposits. In addition, they also protect against cardiovascular diseases. Researchers from the University Hospital Bonn (UKB) and the Transdisciplinary Research Area “Life & Health” at the University of Bonn have now identified the protein EPAC1 as a new pharmacological target to increase brown fat mass and activity. The long-term aim is to find medicines that support weight loss. The results of the study have now been published in the journal Nature Cell Biology.

Obesity is defined as a pathological increase in white fat, and has become a major problem worldwide, with a greatly increased risk of cardiovascular diseases such as heart attack and stroke.

“Exercise and dieting are not enough to effectively and permanently shed the pounds,” says corresponding author Prof.

Should all patients with COPD exacerbations receive oral steroids, or only those with eosinophilia?

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Japan’s Moon Snipper Landed on the Moon making Japan the fifth nation to accomplish a lunar landing and Astrobiotic’s Peregrine lunar lander reenters Earth’s atmosphere.

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ABC News anchor Robin Roberts was brought to tears on Thursday while reporting on a new cancer treatment breakthrough. The story was about a new means of helping cancer patients find donors for blood stem cell transplants – something that Roberts herself had to deal with during her own cancer battle and subsequent health issues. She shed tears thinking of families who will not have to worry as much as she did.

Roberts presented this story along with Good Morning America co-hosts George Stephanopoulos and Lara Spencer. They explained how patients previously had to find a near perfect match for a blood stem cell transplant. This was a particular issue for people of color, but this new breakthrough more than doubles their chances of finding a match. They illustrated the effects with the real-life story of a girl who recently survived a cancer diagnosis that would have been much more dangerous beforehand. Roberts explained how broadening the list of potential donors can be so helpful – and can improve the mindsets of patients and their families as well.

Summary: Physical activity enhances the ability to learn and remember motor skills. The new research involved 67 young men and explored how exercise before and after motor skill learning impacts memory retention.

The study found that exercising both before and after learning optimizes memory formation, with a notable 10% improvement in remembering motor skills. This research is significant for various fields, from rehabilitation to skill training, demonstrating that incorporating physical activity can enhance learning effectiveness.

Using a biosensor to detect cystic fibrosis as the test case, TU/e researchers have devised an innovative way to train neuromorphic chips as presented in a new paper in Nature Electronics.

Neuromorphic computers—which are based on the structure of the human brain—could revolutionize our future health care devices. However, their widespread use is hindered by the need to train neuromorphic computers using external training software, which can be time-consuming and energy inefficient.

Researchers from Eindhoven University of Technology and Northwestern University in the U.S. have developed a new neuromorphic biosensor capable of on-chip learning that doesn’t need external training. As a proof-of-concept, the researchers used the biosensor to diagnose cystic fibrosis based on sweat samples.

Mesolithic Scandinavians likely faced oral health issues, with studies on ancient birch tar revealing signs of gum disease, tooth decay, and diverse dietary habits.

Members of a hunter-gatherer group that lived in south-western Scandinavia during the Mesolithic era — approximately 10,000 years ago — may have been affected by tooth decay and gum disease, according to a study published today (January 18) in Scientific Reports.

DNA Analysis of Birch Tar.

Three different HIV antibodies each independently protected monkeys from acquiring simian-HIV (SHIV) in a placebo-controlled proof-of-concept study intended to inform development of a preventive HIV vaccine for people. The antibodies—a human broadly neutralizing antibody and two antibodies isolated from previously vaccinated monkeys—target the fusion peptide, a site on an HIV surface protein that helps the virus fuse with and enter cells. The study, published in Science Translational Medicine, was led by the Vaccine Research Center (VRC) at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

Antibodies that target the fusion peptide can neutralize diverse strains of HIV in vitro, that is, in a test tube or culture dish outside of a living organism. The NIAID VRC isolated a fusion peptide-directed human antibody, called VRC34.01, from a person living with HIV who donated blood samples for research. They also isolated two antibodies from rhesus macaques—a species of monkey with immune systems like humans’—who previously had received a vaccine regimen designed to generate fusion peptide-directed antibodies. Demonstrating that these antibodies protect animals would validate the fusion peptide as a target for human vaccine design. SHIV challenge—administering an infective dose of SHIV—to rhesus macaques is a widely used animal model for assessing the performance of HIV antibodies and vaccines.

In this study, rhesus macaques in each of four groups received a single intravenous infusion of one type of antibody—a 2.5 or 10 mg/kg of bodyweight dose of VRC34.01, or one of the two vaccine-elicited rhesus macaque antibodies—and other monkeys received a placebo infusion. To determine the protective effect of the antibodies, each monkey was challenged five days after infusion with a strain of SHIV known to be sensitive to fusion peptide-directed antibodies.

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