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Category: genetics – Page 3

Extract from “Evolution, Basal Cognition and Regenerative Medicine”, kindly contributed by Michael Levin in SEMF’s 2023 Interdisciplinary Summer School (https://semf.org.es/school2023/). Full talk: • Michael Levin | Evolution, Basal Cogn… TALK ABSTRACT Each of us has made the remarkable journey from a single cell (a quiescent oocyte) to a complex embodied mind. How do cells, which were once independent organisms, work together to pursue the anatomical and physiological goals that enable form and function to reliably self-assemble? In this talk, I will tell the story of the collective intelligence of cellular swarms that embodies William James’ definition of intelligence: same ends by different means. I will describe the amazing competencies of the morphogenetic process that builds bodies and minds, and our discoveries on bioelectricity — the cognitive glue that implements embryogenesis, regeneration, and cancer suppression. I will end with a perspective on how biophysical, informational, and behavioral sciences are coming together to redefine the boundaries of the possible in biomedicine and beyond. MICHAEL LEVIN Department of Biology, Tufts University: https://as.tufts.edu/biology Tufts University profile: https://ase.tufts.edu/biology/labs/le… Institute profile: https://wyss.harvard.edu/team/associa… Wikipedia: https://en.wikipedia.org/wiki/Michael… ) Google Scholar: https://scholar.google.com/citations?… Twitter: / drmichaellevin LinkedIn: / michael-levin-b0983a6 SEMF NETWORKS Website: https://semf.org.es Twitter: / semf_nexus LinkedIn: / semf-nexus Instagram: / semf.nexus Facebook: / semf.nexus

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An investigational gene therapy has successfully restored immune function in all nine children treated with the rare and life-threatening immune disorder called severe leukocyte adhesion deficiency-I, or LAD-I, in an international clinical trial co-led by UCLA.

LAD-I is a genetic condition that affects approximately one in a million people in the world. It is caused by mutations in the gene that produces CD18, a protein that enables to travel from the bloodstream to infection sites.

In the absence of this critical protein, individuals with severe LAD-I—most of whom are diagnosed within their first months of life—are left vulnerable to dangerous, recurrent bacterial and fungal infections. Survival beyond childhood is rare without treatment.

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Traditional biochemical methods of studying human gene mutations are often laborious and costly. Now bioengineers at the University of California San Diego have developed a new simple approach to rapidly check on human gene changes and also screen chemicals as potential drugs by turning everyday bacteria into living test tubes.

The researchers published their new study in the April 30 issue of Nature Biomedical Engineering.

Human cells carry thousands of genes, and tiny changes in these genes can cause serious diseases. Usually, scientists study these changes by testing proteins in a test tube or in human cells. But those methods can be slow, expensive and sometimes hard to do.

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A new study involving over 700 older adults suggests that taking one gram of omega-3 daily may help slow biological aging, with effects visible in molecular markers known as epigenetic clocks.

When combined with vitamin D and regular exercise, the anti-aging benefits became even more pronounced, lowering the risks of frailty and cancer as well.

Omega-3 linked to slower aging in humans.

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The presence of cellular defects of multifactorial nature can be hard to characterize accurately and early due to the complex interplay of genetic, environmental, and lifestyle factors. With this study, by bridging optically-induced dielectrophoresis (ODEP), microfluidics, live-cell imaging, and machine learning, we provide the ground for devising a robotic micromanipulation and analysis system for single-cell phenotyping. Cells under the influence of nonuniform electric fields generated via ODEP can be recorded and measured. The induced responses obtained under time-variant ODEP stimulation reflect the cells’ chemical, morphological, and structural characteristics in an automated, flexible, and label-free manner.

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QIMR Berghofer-led research has shown that new advanced computational prediction tools can improve the accuracy of genetic testing for families affected by an inherited condition that significantly increases their risk of developing cancer, paving the way to better targeted care.

The findings have been published in the American Journal of Human Genetics alongside complementary studies by international collaborators, which together show how incorporating the new computational biology tools with existing modeling methods improved the predictive power of genetic test results.

Computational tools are used to predict if and how a genetic is likely to impact the function of the protein encoded by the gene.

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Plants are susceptible to a wide range of pathogens. For the common potato plant, one such threat is Pectobacterium atrosepticum, a bacterium that causes stems to blacken, tissues to decay, and often leads to plant death, resulting in significant agricultural losses each year.

In 2012, researchers isolated a new virus that infects and kills this bacterium—a bacteriophage named φTE (phiTE). Now, for the first time, scientists have uncovered the atomic structure of φTE, revealing a possible mechanism of infection that may be more complex than previously thought.

The study, published earlier this month in Nature Communications, is the result of a multidisciplinary collaboration between researchers from the Okinawa Institute of Science and Technology (OIST) and the University of Otago. It brings together expertise across several fields, including virology, , , protein engineering, biochemistry, and biophysics.

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Discount Links/Affiliates:
Blood testing (where I get the majority of my labs): https://www.ultalabtests.com/partners/michaellustgarten.

At-Home Metabolomics: https://www.iollo.com?ref=michael-lustgarten.
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NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/

Continue reading “Can Riboflavin Increase NAD, Decrease Homocysteine?” | >

Certain DNA sequences can form structures other than the canonical double helix. These alternative DNA conformations—referred to as non-B DNA—have been implicated as regulators of cellular processes and of genome evolution, but their DNA tends to be repetitive, which until recently made reliably reading and assembling their sequences difficult.

Now, a team of researchers, led by Penn State biologists, has comprehensively predicted the location of non-B DNA structures in great apes. It’s the first step in understanding the functions and evolution of such structures, known to contribute to genetic diseases and cancer, the team said.

The work depends on newly available telomere-to-telomere (T2T), or end-to-end, genomes of humans and other great apes that overcame sequencing and assembly difficulties associated with repetitive DNA to fill in any remaining gaps in the genomes. A paper describing the study, which shows that non-B DNA is enriched in the newly sequenced segments of the genomes and suggests potential new functions, was published in the journal Nucleic Acids Research.

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Studies by a growing number of labs have identified neurological health benefits from exposing human volunteers or animal models to light, sound and/or tactile stimulation at the brain’s “gamma” frequency rhythm of 40Hz. In the latest such research at The Picower Institute for Learning and Memory and Alana Down Syndrome Center at MIT, scientists found that 40Hz sensory stimulation improved cognition and circuit connectivity and encouraged the growth of new neurons in mice genetically engineered to model Down syndrome.

Li-Huei Tsai, Picower Professor at MIT and senior author of the new study in PLOS ONE, said that the results are encouraging but also cautioned that much more work is needed to test whether the method, called GENUS (for Gamma Entrainment Using Sensory Stimulation), could provide clinical benefits for people with Down syndrome. Her lab has begun a small study with human volunteers at MIT.

“While this work, for the first time, shows the beneficial effects of GENUS on Down syndrome using an imperfect mouse model, we need to be cautious as there is not yet data showing whether this also works in humans,” said Tsai, who directs The Picower Institute and The Alana Center, and is a member of MIT’s Brain and Cognitive Sciences faculty.

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