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Introducing GPT-4.1 in the API

GPT‑4.1, GPT‑4.1 mini, and GPT‑4.1 nano are available now to all developers.

Through efficiency improvements to our inference systems, we’ve been able to offer lower prices on the GPT‑4.1 series. GPT‑4.1 is 26% less expensive than GPT‑4o for median queries, and GPT‑4.1 nano is our cheapest and fastest model ever. For queries that repeatedly pass the same context, we are increasing the prompt caching discount to 75% (up from 50% previously) for these new models. Finally, we offer long context requests at no additional cost beyond the standard per-token costs.

Hydrogen Sulfide (H2S- or H2Sn-Polysulfides) in Synaptic Plasticity: Modulation of NMDA Receptors and Neurotransmitter Release in Learning and Memory

Hydrogen sulfide (H2S) has emerged as a pivotal gaseous transmitter in the central nervous system, influencing synaptic plasticity, learning, and memory by modulating various molecular pathways. This review examines recent evidence regarding how H2S regulates NMDA receptor function and neurotransmitter release in neuronal circuits. By synthesizing findings from animal and cellular models, we investigate the impacts of enzymatic H2S production and exogenous H2S on excitatory synaptic currents, long-term potentiation, and intracellular calcium signaling. Data suggest that H2S interacts directly with NMDA receptor subunits, altering receptor function and modulating neuronal excitability. Simultaneously, H2S promotes the release of neurotransmitters such as glutamate and GABA, shaping synaptic dynamics and plasticity.

Scientists stunned after discovering Earth’s ‘heartbeat’ that sounds every 26 seconds

Scientists have detected a rhythmic ‘heartbeat’ occurring in the centre of the Earth.

It’s not big enough to be felt like an earthquake, but it’s noticeable enough for seismologists around the world to pick up a tiny, measurable ‘blip’ on their radars. Referred to as a ‘microseism’ by geologists, the pulse was first observed coming from the ocean and occurs roughly every 26 seconds.

It’s been quietly pulsing for decades, but scientists aren’t entirely sure what’s causing it.

Tron Ares Trailer Breaks Records

Disney has finally taken us back to The Grid. This video goes over everything revealed in the official Tron Ares Trailer as well as other information we’ve learned.

Thumbnail Credit: https://gmunk.com/TRON-Concepts.
Background Credit: https://youtu.be/cragUPBty8U
3.0 Concept Art Credit: https://www.reddit.com/r/tron/comments/1hnir4i/tron_30_end_o…and_pitch/
Ares Concept Art Credit: https://www.instagram.com/p/DIMc2uXvJhQ/?hl=en&img_index=1

Join The Tron Community Discord Server & Discuss Tron Ares! https://discord.gg/QvGrBKrtGW