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Increasingly the vegetarian diet seems promising in terms of longevity strategy. Here is a short article exploring this idea.


Our ability to live a long life is influenced by a combination of our genes and our environment. In studies that involve identical twins, scientists have estimated that no more than 30 percent of this influence comes from our genes, meaning that the largest group of factors that control how long a person lives is their environment.

Of the many possible environmental factors, few have been as thoroughly studied or debated as our diet. Calorie restriction, for example, is one area that is being investigated.

So far, studies seem to show that restricting calories can increase lifespan, at least in small creatures. But what works for mice doesn’t necessarily work for humans.

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Struggling with your diet? Your microbiota could be to blame.


Your microbiota may not be on your side as you try improving your diet this New Year’s. In a study published December 29 in Cell Host & Microbe, researchers explore why mice that switch from an unrestricted American diet to a healthy, calorie-restricted, plant-based diet don’t have an immediate response to their new program. They found that certain human gut bacteria need to be lost for a diet plan to be successful.

“If we are to prescribe a to improve someone’s health, it’s important that we understand what help control those beneficial effects,” says Jeffrey Gordon, Director of the Center for Genome Sciences and Systems Biology at Washington University in St. Louis and senior author of the paper. “And we’ve found a way to mine the gut microbial communities of different humans to identify the organisms that help promote the effects of a particular diet in ways that might be beneficial.”

In order to study how human dietary practices influence the and how a microbiota conditioned with one dietary lifestyle responds to a new prescribed diet, Gordon and his collaborators first took fecal samples from people who followed a calorie-restricted, plant-rich diet and samples from people who followed a typical, unrestricted American diet. The researchers found that people who followed the restricted, plant-rich diet had a more diverse microbiota.

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If you loathe having to talk out loud when ordering a meal at a fast-food restaurant, and you happen to love KFC, then you might want to start considering packing it up and moving to China where Baidu has just teamed up with the major chicken brand to create a more automated restaurant. The venture aims to use the company’s latest technologies to bring novel ways of providing service to KFC customers.

As an added feature, the outlet also offers augmented reality games via table stickers, a concept also made available to 300 other KFC locations in Beijing.

Baidu’s tech in this new restaurant, however, is all about guessing what you want before you can even ask; image recognition hardware installed at the KFC will scan customer faces, seeking to infer moods, and guess other information including gender an age in order to inform their recommendation.

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Nice; using gene regulatory protein from yeast as a method for reducing the work required for making cell-specific perturbations.


The human brain, the most complex object in the universe, has 86 billion neurons with trillions of yet-unmapped connections. Understanding how it generates behavior is a problem that has beguiled humankind for millennia, and is critical for developing effective therapies for the psychiatric disorders that incur heavy costs on individuals and on society. The roundworm C elegans, measuring a mere 1 millimeter, is a powerful model system for understanding how nervous systems produce behaviors. Unlike the human brain, it has only 302 neurons, and has completely mapped neural wiring of 6,000 connections, making it the closest thing to a computer circuit board in biology. Despite its relative simplicity, the roundworm exhibits behaviors ranging from simple reflexes to the more complex, such as searching for food when hungry, learning to avoid food that previously made it ill, and social behavior.

Understanding how this dramatically simpler nervous system works will give insights into how our vastly more complex brains function and is the subject of a paper published on December 26, 2016, in Nature Methods.

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Caloric restriction can help tumour supression.


Tumor suppressors stop healthy cells from becoming cancerous. Researchers from Charité — Universitätsmedizin Berlin, the Medical University of Graz and the German Institute of Human Nutrition in Potsdam-Rehbruecke have found that p53, one of the most important tumor suppressors, accumulates in liver after food withdrawal. They also show that p53 in liver plays a crucial role in the body’s metabolic adaptation to starvation. These findings may provide the foundation for the development of new treatment options for patients with metabolic or oncologic disorders. Results of this study have been published in The FASEB Journal.

Previously described as the ‘guardian of the genome’ and voted ‘Molecule of the Year’ in 1993, p53 is one of the most important proteins regulating cell growth and a major focus for oncology research. It is a protein that has the ability to interrupt the cell cycle and block the division of diseased cells. In order to better understand its physiological regulation, the researchers around Prof. Dr. Michael Schupp from Charité’s Institute of Pharmacology studied the regulation and function of p53 in normal, . After withholding food from mice for several hours, the researchers were able to show that p53 protein accumulates in the liver. In order to determine which type of cause this accumulation, the researchers repeated the experiment using cultured hepatocytes. They found that the starvation-induced accumulation of p53 was indeed detectable in hepatocytes, irrespective of whether these cells were of mouse or human origin.

“Our data also suggest that the accumulation of p53 is mediated by a cellular energy sensor, and that it is crucial for the metabolic changes associated with starvation,” explains Prof. Michael Schupp. The researchers were able to show that mice with an acute inactivation of the p53 gene in liver had difficulties in adapting their metabolisms to starvation. “Food intake seems crucial in determining the protein levels of p53 in liver, and p53 also plays an important role in normal liver metabolism,” says Prof. Schupp. The researchers are planning to study whether their observations are limited to liver cells, or whether this p53 accumulation also occurs in other tissues and organs. Prof.

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In “Passengers,” a 2016 science-fiction thriller film two space travelers wake up 90 years too soon from an induced hibernation on board a spaceship bound for a new planet. From “Aliens” to “Interstellar,” Hollywood has long used suspended animation to overcome the difficulties of deep space travel, but the once-fanciful sci-fi staple is becoming scientific fact. The theory is that a hibernating crew could stay alive over vast cosmic distances, requiring little food, hydration or living space, potentially slashing the costs of interstellar missions and eradicating the boredom of space travel.

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Happy Holidays; happy end of the year, happy launch of next year, happy snow days, happy hot chocolate day, etc. Nonetheless, my gift to you this year is a Nanoscale Snowman.


Would a jewel-encrusted snowman make the perfect Christmas present? At only 5 nanometres in size, the price might be lower than you think. And it’s functional too, catalysing the splitting of water to make green hydrogen for fuel cells.

The nanoparticle, as imaged with the aberration-corrected scanning transmission electron microscopes, features eyes, nose and mouth of precious-metal platinum clusters embedded in a titanium dioxide face. Each platinum cluster typically contains 30 platinum atoms; within the whole nanoparticle there are approximately 1680 and 180 platinum atoms.

The nano-snowman formed spontaneously from a self-assembled platinum-titanium nanoparticle which was oxidised in air, drawing the titanium atoms out to the surface. The self-assembly occurred in a gas phase, cluster beam condensation source, before size-selection with a spectrometer and deposition onto a carbon surface for oxidation and then imaging. The mass of the snowman was 120,000 atomic mass units. Compared with a more conventional pure platinum catalyst particle, the inclusion of the titanium atoms offers two potential benefits: dilution of how much precious platinum is needed to perform the catalysis, and protection of the cores against sintering (i.e. aggregation of the nanoparticles). The shell is porous enough to allow hydrogen through and the particles are functional in the evolution reaction.

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