Lifeboat Foundation

Researchers created a mathematical framework to examine the genome and detect signatures of natural selection, deciphering the evolutionary past and future of non-coding DNA.

Despite the sheer number of genes that each human cell contains, these so-called “coding” DNA sequences comprise just 1% of our entire genome. The remaining 99% is made up of “non-coding” DNA — which, unlike coding DNA, does not carry the instructions to build proteins.

One vital function of this non-coding DNA, also called “regulatory” DNA, is to help turn genes on and off, controlling how much (if any) of a protein is made. Over time, as cells replicate their DNA to grow and divide, mutations often crop up in these non-coding regions — sometimes tweaking their function and changing the way they control gene expression. Many of these mutations are trivial, and some are even beneficial. Occasionally, though, they can be associated with increased risk of common diseases, such as type 2 diabetes, or more life-threatening ones, including cancer.

READER QUESTION: If humans don’t die out in a climate apocalypse or asteroid impact in the next 10,000 years, are we likely to evolve further into a more advanced species than what we are at the moment? Harry Bonas, 57, Nigeria

Humanity is the unlikely result of four billion years of evolution.

From self-replicating molecules in Archean seas, to eyeless fish in the Cambrian deep, to mammals scurrying from dinosaurs in the dark, and then, finally, improbably, ourselves—evolution shaped us.

In their pursuit of understanding cosmic evolution, scientists rely on a two-pronged approach. Using advanced instruments, astronomical surveys attempt to look farther and farther into space (and back in time) to study the earliest periods of the Universe. At the same time, scientists create simulations that attempt to model how the Universe has evolved based on our understanding of physics. When the two match, astrophysicists and cosmologists know they are on the right track!

In recent years, increasingly-detailed simulations have been made using increasingly sophisticated supercomputers, which have yielded increasingly accurate results. Recently, an international team of researchers led by the University of Helsinki conducted the most accurate simulations to date. Known as SIBELIUS-DARK, these simulations accurately predicted the evolution of our corner of the cosmos from the Big Bang to the present day.

In addition to the University of Helsinki, the team was comprised of researchers from the Institute for Computational Cosmology (ICC) and the Centre for Extragalactic Astronomy at Durham University, the Lorentz Institute for Theoretical Physics at Leiden University, the Institut d’Astrophysique de Paris, and The Oskar Klein Centre at Stockholm University. The team’s results are published in the Monthly Notices of the Royal Astronomical Society.

Biologists have discovered the largest bacterium ever found, with a single cell measuring a mammoth 2 cm (0.8 in) long. Visible to the naked eye, this new species has some bizarre characteristics that make it like a missing link in the evolution of complex cells like those in humans.

Most species of bacteria measure between one and five micrometers long, but the biggest previously known was Thiomargarita namibiensis, which tops out at 750 micrometers or 0.75 mm. But this newly identified species blows everything else out of the water – its average length is a whopping 9,000 micrometers (0.9 cm/0.4 in), with the largest recorded specimen reaching 2 cm. This single cell is longer than your everyday housefly.

This gigantic size completely upends the accepted scientific understanding of how big bacteria could possibly get. It was long believed that the size of bacteria was limited by the distance that the molecules they exchange with their environment could travel. If nutrients can’t make the journey from their membrane to their interior, and if toxins can’t do the reverse trip, the organism wouldn’t be viable.

Study of the evolution of monotheism is instructive. Jolly Jehovah did not burst forth fully formed overnight. Prof Orly Goldwasser explains how Amen and Ra are “better” Gods than Set of Avaris, the first recorded monotheist deity in her 2006 paper on King Apophis. There is evidence of interchangeable identity between Set and Ba’al Hadad. “According to the Canaanite pantheon, known in Ugarit as ‘ilhm (=Elohim) or the children of El (cf. the Biblical “sons of God”), supposedly obtained by Philo of Byblos from Sanchuniathon of Berythus (Beirut) the creator was known as Elion (Biblical El Elyon = God most High), who was the father of the divinities, and in the Greek sources he was married to Beruth (Beirut = the city). This marriage of the divinity with the city would seem to have Biblical parallels too with the stories of the link between Melkart and Tyre; Yahweh and Jerusalem; Chemosh and Moab; Tanit and Baal Hammon in Carthage. El Elyon is mentioned as ‘God Most High’ occurs in Genesis 14.18−19 as the God whose priest was Melchizedek king of Salem.”

Canaanite religion is the name for the group of Ancient Semitic religions practiced by the Canaanites living in the ancient Levant from at least the early Bronze Age through the first centuries of the Common Era. Canaanite religion was polytheistic or monolatristic, worshiping one god while acknowledging the existence of others. The sources for Canaanite religion come either from literary sources written by the early Hebrews, or from archaeological discoveries. The Canaanite wrote on papyrus and.

In a way, it could mean climate change is linked to an “immature technosphere”.

It’s called an epiphenomenon.

Continue reading “Can a planet ‘think’? The bold idea gets new backing” »

There is a cyborg organoid platform developed by integrating “tissue-like” stretchable mesh nanoelectronics with 2D stem cell sheets. Leveraging the 2D-to-3D reconfiguration during organoid development, 2D stem cell sheets fold and embed stretchable mesh nanoelectronics with electrodes throughout the entire 3D organoid. The embedded electronics can then enable continuous electrical recording.

Scientists design stretchable mesh nanoelectronics, mimicking the mechanical and structural properties of brain organoids to build cyborg human brain organoids.

Using the 3D embedded stretchable electrodes, achieved reliable long-term electrical recording of the same hiPSC-derived neural tissue at single-cell, millisecond spatiotemporal resolution for 6 months, revealing the evolution of the tissue-wide single-cell electrophysiology over hiPSC-derived neuron development. Applying this technology to brain organoids at early developmental stages, they traced the gradually emerging single-cell action potentials and network activities.

Continue reading “Stretchable Mesh Nanoelectronics for 3D Single‐Cell Chronic Electrophysiology from Developing Brain Organoids” »

A study by the University of Bonn: Observations fit poorly with the Standard Model of Cosmology.

The Standard Model of Cosmology describes how the universe came into being according to the view of most physicists. Researchers at the University of Bonn have now studied the evolution of galaxies within this model, finding considerable discrepancies with actual observations. The University of St. Andrews in Scotland and Charles University in the Czech Republic were also involved in the study. The results have now been published in the Astrophysical Journal.

Most galaxies visible from Earth resemble a flat disk with a thickened center. They are therefore similar to the sports equipment of a discus thrower. According to the Standard Model of Cosmology, however, such disks should form rather rarely. This is because in the model, every galaxy is surrounded by a halo of dark matter. This halo is invisible, but exerts a strong gravitational pull on nearby galaxies due to its mass. “That’s why we keep seeing galaxies merging with each other in the model universe,” explains Prof. Dr. Pavel Kroupa of the Helmholtz Institute for Radiation and Nuclear Physics at the University of Bonn.