Lifeboat Foundation

Previous morpho-molecular studies of evolutionary relationships within the economically important genus of honey bees (Apis), including the Western Honey Bee (A. mellifera L.), have suggested Out of Africa or Asia origins and subsequent spread to Europe. I test these hypotheses by a meta-analysis of complete mitochondrial DNA coding regions (11.0 kbp) from 22 nominal subspecies represented by 78 individual sequences in A. mellifera. Parsimony, distance, and likelihood analyses identify six nested clades: Things Fall Apart with Out of Africa or Asia hypotheses. Molecular clock-calibrated phylogeographic analysis shows instead a basal origin of A. m. mellifera in Europe ~ 780 Kya, and expansion to Southeast Europe and Asia Minor ~ 720 Kya. Eurasian bees spread southward via a Levantine/Nilotic/Arabian corridor into Africa ~ 540 Kya.

Down beneath the tourist lodges and shops selling keychains and incense, past windswept arroyos and brown valleys speckled with agave, juniper and sagebrush, the rocks of the Grand Canyon seem untethered from time. The oldest ones date back 1.8 billion years, not just eons before humans laid eyes on them, but eons before evolution endowed any organism on this planet with eyes.

Spend long enough in the canyon, and you might start feeling a little unmoored from time yourself. The immense walls form a kind of cocoon, sealing you off from the modern world, with its cell signal and light pollution and disappointments. They draw your eyes relentlessly upward, as in a cathedral.

You might think you are seeing all the way to the top. But up and above are more walls, and above them even more, out of sight except for the occasional glimpse. For the canyon is not just deep. It is broad, too — 18 miles, rim to rim, at its widest. This is no mere cathedral of stone. It is a kingdom: sprawling, self-contained, an alternate reality existing magnificently outside of our own.

Dark matter, the invisible material that makes up the vast majority of the universe’s mass, may collect itself to form atoms, a new simulation shows.

Those “dark atoms” might radically alter the evolution of galaxies and the formation of stars, giving astronomers a new opportunity to understand this mysterious substance.

Today, we explore a timelapse of the future, specifically future technology. How will technology look 1,000 years from now? In the world today, many technologies are accelerating exponentially. Humans are discovering things that would mystify scientists even a few decades ago, but our progress resembles a blip in the grand scale of our technological evolution over the next millennium.

Sources:
https://pastebin.com/raw/1vAehwKn.

Continue reading “Timelapse of Future Technology: Next 1000 Years” »

Worth a listen to understand the current reality and the future potential:

Go to https://ground.news/sabine to stay fully informed on breaking news, compare coverage and avoid media bias. Subscribe using my link to get 30% off the Vantage plan for unlimited access.

Continue reading “Should we take evolution into our own hands and become transhuman?” »

The Big Bang, traditionally considered the birth of the universe about 14 billion years ago, is being questioned. Physicist Bruno Bento and his team have proposed compelling research suggesting the universe may have always existed, and the Big Bang may merely be a significant event in its continuous evolution.

Bruno Bento and his colleagues set out to examine what the universe’s inception might have looked like without a Big Bang singularity. They grappled with contradictions arising when comparing accepted theories, particularly those dealing with quantum physics and general relativity. While quantum physics has accurately described three of the four fundamental forces of nature, it struggles to incorporate gravity. On the other hand, general relativity offers a comprehensive explanation of gravity, but falters when dealing with black holes’ centers and the universe’s genesis.

These contentious areas, termed “singularities,” are points in space-time where established physical laws cease to apply. Intriguingly, computations indicate an immense gravitational pull within singularities, even on a minuscule scale.

Hallucination!

Can “hallucinations” generate an alternate world, prophesying falsehood?

As I write this article, NVIDIA^(• is surpassing Wall Street’s expectations. The company, headquartered in Santa Clara, California, has just joined the exclusive club of only five companies in the world valued at over a trillion dollars [Apple (2.7T), Microsoft (2.4T), Saudi Aramco (2T), Alphabet/Google (1.5T), and Amazon (1.2T)], as its shares rose nearly 25% in a single day! A clear sign of how the widespread use of Artificial Intelligence (AI) can dramatically reshape the technology sector.

Intel has announced an ambitious plan to develop scientific generative AIs designed with one trillion parameters. These models will be trained on various types of data, including general texts, code, and scientific information. In comparison, OpenAI’s GPT-3 has 175 billion parameters (the size of GPT-4 has not yet been disclosed by OpenAI). The semiconductor company’s main focus is to apply these AIs in the study of areas such as biology, medicine, climate, cosmology, chemistry, and the development of new materials. To achieve this goal, Intel plans to launch a new supercomputer called Aurora, with processing capacity exceeding two EXAFLOPS^(*•, later this year.

Continue reading “Intelligence Explosion — Part 2/3” »

Year 2017 PD-1 can eventually be used throughout the body to be used on all cancers which also naturally occurs in the body the common cancer drug Keytruda uses this type of targeting to destroy cancer cells.

Several cancers are highly refractory to conventional chemotherapy. The survival of tumors in several cases is assisted by checkpoint immunomodulation to maintain the imbalance between immune surveillance and cancer cell proliferation. Check point antibody inhibitors, such as anti-PD-1/PD-L1, are a novel class of inhibitors that function as a tumor suppressing factor via modulation of immune cell-tumor cell interaction. These checkpoint blockers are rapidly becoming a highly promising cancer therapeutic approach that yields remarkable antitumor responses with limited side effects. In recent times, more than four check point antibody inhibitors have been commercialized for targeting PD-1, PDL-1, and CTLA-4. Despite the huge success and efficacy of the anti-PD therapy response, it is limited to specific types of cancers, which attributes to the insufficient and heterogeneous expression of PD-1 in the tumor microenvironment. Herein, we review the current landscape of the PD-1/PD-L1 mechanistic role in tumor immune evasion and therapeutic outcome for cancer treatment. We also review the current progress in clinical trials, combination of drug therapy with immunotherapy, safety, and future of check point inhibitors for multiple types of cancer.

Immunotherapy is an exciting approach, and tremendous strides have recently been made in our perception of the role of the host immune response in affecting tumor growth and response to various therapies (Pardoll, 2012). Through these advances, novel immune check point inhibitors have been identified and cleared for use in the clinic (Figure 1). The evolution of immune checkpoint inhibitors as anticancer treatment options represents one of the most successful approach in cancer drug discovery in the past few years (Couzin-Frankel, 2013). Indeed, immune checkpoint inhibitors have emerged as a frontline treatment for multiple cancers, such as metastatic melanoma, non-small cell lung cancer (NSCLC), renal cell carcinoma (RCCs), and bladder or urothelial cancer. They are presently being assessed in numerous other cancer types, including breast cancer, head and neck cancer, and some advanced solid and hematological malignancies.

The theory of evolution, worked out in the nineteenth century by Charles Darwin and Alfred Russel Wallace, with many tweaks since, is one of the most well-supported theories in science.

Evidence from a wide range of disciplines backs up the basics of the theory. Or, as paleontologist and historian of science Stephen Jay Gould put it in an essay in the May 1981 print issue of this magazine, the theory of evolution is “one of the best documented, most compelling and exciting concepts in all of science.”

For the rest of us, one interesting and sometimes confusing aspect of evolution is the difference between convergent and divergent evolution. Here’s a quick explanation.