Lifeboat Foundation

View show notes here: https://bit.ly/3GJjQKz Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sign up to receive Peter’s email newsletter: https://peterattiamd.com/newsletter/ Colleen Cutcliffe is an expert in molecular biology and co-founder of Pendulum Therapeutics, a company working to develop treatments for a variety of diseases by targeting the microbiome. In this episode, Colleen delves into the complexity of the microbiome, how it is tested, and how it changes over time. She explores how probiotics, prebiotics, and postbiotics affect the gut and makes a compelling case that well-developed products have the potential not only to enhance gut health but also to positively influence overall metabolic well-being. Colleen emphasizes the significance of a high-fiber diet in sustaining a thriving gut microbiome, shares insights on minimizing microbiome damage during antibiotic use, provides tips for fostering and preserving a healthy gut, and much more. We discuss: 0:00:00 — Intro 0:00:34 — Colleen’s background and current focus 0:03:08 — The basics of the microbiome 0:12:37 — The study of the human microbiome 0:17:42 — Categories of bacteria, and the implications on health of the rapid evolution of bacteria 0:27:51 — Methods for measuring and understanding the microbiome, and key indicators of microbiome health 0:39:52 — The important role of fiber for promoting gut health through the production of butyrate 0:47:21 — The case for manipulating gut bacteria via fecal microbiota transplant (FMT) 0:53:25 — Dynamics of the microbiome: the gut-brain connection and how antibiotics, nutrition, stress, and more impact the microbiome’s diversity and function 0:59:16 — Factors that influence the vaginal microbiom 1:03:46 — The effect of gut microbes on obesity and challenges with fecal transplants in people 1:06:25 — Beneficial strains of gut bacteria and strains commonly found in probiotics 1:16:35 — The difference between a probiotic and prebiotic, and how CFUs are a measure of the “active ingredient” 1:21:47 — Considerations about how probiotic strains are produced, and more on the meaning of CFU 1:31:12 — Mitigating the effect of antibiotics on the microbiome 1:39:58 — What do we know about the effect of artificial sweeteners on the gut microbiome? 1:47:02 — Why Akkermansia is a keystone strain with implications for metabolic health and an individual’s response to dietary interventions 1:58:14 — The essential steps necessary to develop a robust probiotic for optimal health support 2:01:45 — How Akkermansia helps control blood glucose, and potential implications of Akkermansia in weight loss, diabetes management, and more 2:22:46 — Pendulum Therapeutics’ commitment to rigorous product develop 2:29:54 — Details about the probiotic “Glucose Control” and other probiotics developed by Pendulum Therapeutics 2:38:43 — Further studies of Akkermansia that have been proposed or are underway ——– About: The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 70 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more. Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.

When two lead ions collide at the Large Hadron Collider (LHC), they produce an extremely hot and dense state of matter in which quarks and gluons are not confined inside composite particles called hadrons. This fireball of particles—known as quark–gluon plasma and believed to have filled the universe in the first few millionths of a second after the Big Bang—expands and cools down rapidly. The quarks and gluons then transform back into hadrons, which fly out of the collision zone towards particle detectors.

In collisions where the two lead ions do not collide head on, the overlap region between the ions has an elliptic shape that leaves an imprint on the flow of hadrons. Measurements of such elliptic flow provide a powerful way to study quark–gluon plasma. In a recent paper posted to the arXiv preprint server, the ALICE collaboration reported a new measurement of the elliptic flow of hadrons containing heavy quarks, which are particularly powerful probes of the plasma.

Unlike the gluons and light quarks that make up the bulk of the quark–gluon plasma created in heavy-ion collisions, heavy charm and beauty quarks are produced in the initial stages of the collisions, before the plasma forms. They therefore interact with the plasma throughout its entire evolution, from its expansion and cooling to its transformation into hadrons.

Evolution has produced a range of diverse proteins, and now a generative model called Chroma can expand that set by allowing the user to design new proteins and protein complexes with desired properties and functions.

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The mystery of aging has fascinated people for millennia, with many willing to do anything to halt or reverse this process, because aging is typically associated with gradual deterioration of most body functions. While senescence is a natural part of life, biologists understand surprisingly little about the emergence of this process during evolution.

It is not clear whether aging is inevitable because there are organisms that seemingly do not age at all; moreover, the phenomenon known as negative aging, or rejuvenation, does exist: for example, some turtles’ vital functions improve with age.

Researchers of the Institute of Evolution led by Academician Eörs Szathmáry have endeavored to prove the validity of a previously proposed but still unproven theory of aging. The theory suggests that under the right circumstances, evolution can favor the proliferation of genes controlling senescence.

Robin Dunbar is an anthropologist, evolutionary psychologist, head of the Social and Evolutionary Neuroscience Research Group at the University of Oxford and an author. Love is something that people have been trying to describe for thousands of years. Beyond asking what love is, is the question of why humans feel something so strange in the first place. Why would evolution have exposed us to this extreme sensation with huge potential for catastrophe and pain? Expect to learn how love is adaptive, why humans need to have more sex than almost all other animals to get pregnant, why ancestral men who hunted big animals were only doing it to get laid, how the length of your fingers can tell you how promiscuous you are, whether Robin thinks humans were ancestrally monogamous and much more…

Dr Andrew Thomas is a senior lecturer of psychology at Swansea University whose research focuses on sex differences and relationship preferences from an evolutionary perspective. Evolution explains a large portion of why we like the things we like. Who we’re attracted to, why we fall into and out of love, how our mental state affects our mating strategies. Therefore, if you are a human who ever intends on being in a relationship, this might be useful. Expect to learn the 5 evolutionary theories which explain much of human mating, whether ChatGPT can correctly predict what traits men and women like most in each other, how many previous sexual partners people say they want their current partner to have had, how open men & women in the West are to polyamorous relationships, how sexual arousal can ruin a faithful relationship and much more… Sponsors: Get 20% discount & free shipping on your Lawnmower 4.0 at https://manscaped.com/modernwisdom (use code MODERNWISDOM) Get over 37% discount on all products site-wide from MyProtein at https://bit.ly/proteinwisdom (use code: MODERNWISDOM) Get 83% discount & 3 months free from Surfshark VPN at https://surfshark.deals/MODERNWISDOM (use code MODERNWISDOM) Extra Stuff: Follow Andrew on Twitter — https://twitter.com/DrThomasAG Get my free Reading List of 100 books to read before you die → https://chriswillx.com/books/ To support me on Patreon (thank you): https://www.patreon.com/modernwisdom #evolution #dating #psychology — 00:00 Intro 01:20 Evolutionary Mismatch 10:18 Evolving Towards Making Small Errors Instead of Big Ones 17:33 Are Men as Picky as Women? 21:55 Is Promiscuity Heritable? 27:32 Humans Engage in Multiple Types of Sexual Strategies 36:49 The Different Levels of Sexual Harassment 46:55 Is Sexlessness in Young Men Caused by Poor Social Skills? 52:56 Attitudes in the West to Having Multiple Sexual Partners 1:04:21 How Many Previous Sexual Partners is Too Much? 1:14:52 What ChatGPT Gets Wrong About Mate Preferences 1:34:31 Where to Find Dr Thomas — Get access to every episode 10 hours before YouTube by subscribing for free on Spotify — https://spoti.fi/2LSimPn or Apple Podcasts — https://apple.co/2MNqIgw Get my free Reading List of 100 life-changing books here — https://chriswillx.com/books/ — Get in touch in the comments below or head to… Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx Email: https://chriswillx.com/contact/

The advancement of higher cognitive abilities in humans is predominantly associated with the growth of the neocortex, a brain area key to conscious thinking, movement, and sensory perception. Researchers are increasingly realizing, however, that the “little brain” or cerebellum also expanded during evolution and probably contributes to the capacities unique to humans, explains Prof. Henrik Kaessmann from the Center for Molecular Biology of Heidelberg University.

His research team has – together with Prof. Dr Stefan Pfister from the Hopp Children’s Cancer Center Heidelberg – generated comprehensive genetic maps of the development of cells in the cerebella of humans, mice, and opossums. Comparisons of these data reveal both ancestral and species-specific cellular and molecular characteristics of cerebellum development spanning over 160 million years of mammalian evolution.

An anomalous Floquet topological insulator (AFTI) is a periodically driven topological insulator (TI with nonzero winding numbers to support topological edge modes, though its standard topological invariants like Chern numbers are zero.

The photonic lattice constructed by an optical waveguide array fabricated by the femtosecond laser direct writing (FLDW) is an important platform for quantum simulation to realize photonic AFTIs, because the FLDW offers flexible design of true three-dimensional (3D) waveguide structures and precise control of each coupling between waveguides. Moreover, the evolution distance of the lattice can be mapped as the evolution time.

In femtosecond-laser-direct-written photonic AFTIs, selective coupling of adjacent waveguides in a cycle is explicitly defined by the discrete periodically driving protocol. At the complete transfer discrete driving protocol, chiral edge modes co-exist with dispension-less bulk modes, and the lattice energy transfer efficiency of the chiral edge mode is the highest among all TIs (close to 100%), so it is very suitable for the transport of fragile quantum states.