Lifeboat Foundation

Helicobacter pylori, a globally distributed gastric bacterium, is genetically highly adaptable. Microbiologists at LMU have now characterized its population structure in individual patients, demonstrating an important role of antibiotics for its within-patient evolution.

The cosmopolitan bacterium Helicobacter pylori is responsible for one of the most prevalent chronic infections found in humans. Although the infection often provokes no definable symptoms, it can result in a range of gastrointestinal tract pathologies, ranging from inflammation of the lining of the stomach to gastric and duodenal tumors. Approximately 1 percent of all those infected eventually develop stomach cancer, and the World Health Organization has classified H. pylori as a carcinogen. One of Helicobacter pylori’s most striking traits is its genetic diversity and adaptability. Researchers led by microbiologist Sebastian Suerbaum (Chair of Medical Microbiology and Hospital Epidemiology at LMU’s Max von Pettenkofer Institute have now examined the genetic diversity of the species in the stomachs of 16 patients, and identified specific adaptations that enable the bacterium to colonize particular regions of the stomach.

What is dark matter made of? It’s one of the most perplexing questions of modern astronomy. We know that dark matter is out there, since we can see its obvious gravitational influence on everything from galaxies to the evolution of the entire universe, but we don’t know what it is. Our best guess is that it’s some sort of weird new particle that doesn’t like to talk to normal matter very often (otherwise, we would have seen it by now). One possibility is that it’s an exotic hypothetical kind of particle known as an axion, and a team of astronomers are using none other than black holes to try to get a glimpse into this strange new cosmic critter.

Axion Agenda

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To answer the iconic question “Are We Alone?”, scientists around the world are also attempting to understand the origin of life. There are many pieces to the puzzle of how life began and many ways to put them together into a big picture. Some of the pieces are firmly established by the laws of chemistry and physics. Others are conjectures about what Earth was like four billion years ago, based on extrapolations of what we know from observing Earth today. However, there are still major gaps in our knowledge and these are necessarily filled in by best guesses.

We invited talented scientists to discuss their different opinions about the origin of life and the site of life’s origin. Most of them will agree that liquid water was necessary, but if we had a time machine and went back in time, would we find life first in a hydrothermal submarine setting in sea water or a fresh water site associated with emerging land masses?

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In coming years, scientists plan to grow human embryos in a lab using high-tech artificial wombs.

Doctors at the Children’s Hospital of Philadelphia are in talks with the U.S. Food and Drug Administration (FDA) to begin testing artificial wombs on human embryos within the next two years, according to Metro. If they’re successful, the research could radically change the way we view pregnancy, childbirth, and perhaps even human evolution.

Lawrence Livermore National Laboratory (LLNL) scientists in collaboration with University of Nevada Las Vegas (UNLV) have discovered a previously unknown pressure induced phase transition for TATB that can help predict detonation performance and safety of the explosive. The research appears in the May 13 online edition of the Applied Physics Letters and it is highlighted as a cover and featured article.

1,3,5-Triamino-2,4,6- trinitrobenzene (TATB), the industry standard for an insensitive high explosive, stands out as the optimum choice when safety (insensitivity) is of utmost importance. Among similar materials with comparable explosive energy release, TATB is remarkably difficult to shock-initiate and has a low friction sensitivity. The causes of this unusual behavior are hidden in the high-pressure structural evolution of TATB. Supercomputer simulations of explosives detonating, running on the world’s most powerful machines at LLNL, depend on knowing the exact locations of the atoms in the crystal structure of an explosive. Accurate knowledge of atomic arrangement under pressure is the cornerstone for predicting the detonation performance and safety of an explosive.

The team performed experiments utilizing a diamond anvil cell, which compressed TATB single crystals to a pressure of more than 25 GPa (250,000 times atmospheric pressure). According to all previous experimental and theoretical studies, it was believed that the atomic arrangement in the crystal structure of TATB remains the same under pressure. The project team challenged the consensus in the field aiming to clarify the high-pressure structural behaviour of TATB.

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The Aldabra white-throated rail, a flightless bird that lives on its namesake atoll in the Indian Ocean, doesn’t look like anything special at first glance. But the small bird has big bragging rights, because it has effectively evolved into existence twice after first going extinct some 136,000 years ago.

According to a study published Wednesday in the Zoological Journal of the Linnean Society, the rail is an example of a rarely observed phenomenon called iterative evolution, in which the same ancestral lineage produces parallel offshoot species at different points in time. This means that near-identical species can pop up multiple times in different eras and locations, even if past iterations have gone extinct.

Fossils of the flightless bird were found both before and after Albadra was submerged by an “inundation event” that occurred around 136,000 years ago, said study authors Julian Hume, an avian paleontologist at Natural History Museum in London, and David Martill, a paleobiologist at the University of Portsmouth.

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Circa 2011 Talks about he lightcycler.

Carl T. Wittwer, M.D., Ph.D.

Seminal technology continues to be a work in progress.

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Scientists from Trinity College Dublin have discovered a potential new target for regulating inflammation, which drives a range of diseases including diabetes, cancer and Alzheimer’s. The potential target is an ancient immune protein—SARM—that has been conserved throughout evolution and thus is very similar in humans, other mammals, flies and worms.

The scientists, from Trinity’s School of Biochemistry and Immunology based at the Trinity Biomedical Sciences Institute (TBSI), discovered a previously unknown but important role that SARM plays in the immune response. Their work has been published today in the prestigious journal Immunity.

In trying to answer such questions, scientists bump up against the limits of the laws of physics. Existing theories can account for the evolution of the universe from its earliest moments — from a fraction of a second after the Big Bang — but the question of what came before has been among the most vexing in all of science.

“It’s my life’s work to try to answer that question,” University of Toronto physicist Renée Hložek says.

This image represents the evolution of the universe, starting with the Big Bang. The red arrow marks the flow of time.

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