A new method for engineering natural killer cells could make cancer immunotherapy more efficient, scalable, and affordable, potentially reshaping how these treatments are produced.
Category: engineering – Page 2
“Zentropy Theory” May Unlock Previously Impossible Electronics Based on Transparent Ceramics
“There was no existing theory in the ferroelectrics community that could explain these results,” Liu explained.
Keeping Chaos at Bay with Small Amounts of Energy
To unlock the advanced material’s performance and open up potential commercial applications, Haixue Yan, a reader in materials science and engineering from Queen Mary University of London, explored several different ideas. That search effort led him to Liu’s relatively new zentropy theory idea. According to a statement announcing the new approach, zentropy theory suggests that systems trend towards disorder “if no energy is applied to keep the chaos at bay.”
5 Sci-Fi Fantasies That Could Soon Become Reality
Five sci-fi technologies becoming real today, from BCIs to space elevators.
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Credits:
5 Sci-Fi Fantasies That Could Soon Become Reality.
Written, Produced & Narrated by: Isaac Arthur.
Editor: Donagh Broderick.
Select imagery/video supplied by Getty Images.
Chapters.
0:00 Intro.
1:52 Brain-Computer Interfaces (BCI)
6:26 Dream Recording & Memory Replay.
8:48 Artificial Wombs & Designer Babies.
16:13 Bio.
18:56 Space Elevators.
21:12 Weather Control.
21:30 Graphene.
22:15 De-Extinciton.
21:40 Superconductors & Fusion.
27:23 Oldest & Newest.
28:26 Preserving & Rebuilding the Human Body.
Nanoparticle therapy reprograms tumor immune cells to attack cancer from within
Within tumors in the human body, there are immune cells (macrophages) capable of fighting cancer, but they have been unable to perform their roles properly due to suppression by the tumor. A KAIST research team led by Professor Ji-Ho Park of the Department of Bio and Brain Engineering have overcome this limitation by developing a new therapeutic approach that directly converts immune cells inside tumors into anticancer cell therapies.
In their approach, when a drug is injected directly into a tumor, macrophages already present in the body absorb it, produce CAR (a cancer-recognizing device) proteins on their own, and are converted into anticancer immune cells known as “CAR-macrophages.” The paper is published in the journal ACS Nano.
Solid tumors —such as gastric, lung, and liver cancers—grow as dense masses, making it difficult for immune cells to infiltrate tumors or maintain their function. As a result, the effectiveness of existing immune cell therapies has been limited.
New sensor measures strain, strain rate and temperature with single material layer
Researchers from the Institute of Metal Research (IMR) of the Chinese Academy of Sciences have developed an innovative flexible sensor that can simultaneously detect strain, strain rate, and temperature using a single active material layer, representing a significant advance in multimodal sensing technology.
The study, published in Nature Communications, addresses the longstanding challenge of conventional sensors requiring complex multilayer designs that integrate different materials for distinct sensing functions. These traditional approaches often involve complicated signal acquisition and external power supplies, limiting their reliability in continuous monitoring applications.
Led by Prof. Tai Kaiping, the researchers designed the sensor based on a specially designed network of tilted tellurium nanowires (Te-NWs). Through material and structural engineering, they overcame a fundamental limitation where thermoelectric and piezoelectric signals could not be collected in the same direction within conventional materials. In this unique architecture, both signals are simultaneously detected and output in the out-of-plane direction.
New method uses spin motion to control heat flow in magnetic materials
NIMS, in joint research with the University of Tokyo, AIST, the University of Osaka, and Tohoku University, have proposed a novel method for actively controlling heat flow in solids by utilizing the transport of magnons—quasiparticles corresponding to the collective motion of spins in a magnetic material—and demonstrated that magnons contribute to heat conduction in a ferromagnetic metal and its junction more significantly than previously believed.
The creation of new principles “magnon engineering” for modulating thermal transport using magnetic materials is expected to lead to the development of thermal management technologies. This research result is published in Advanced Functional Materials.
Thermal conductivity is a fundamental parameter characterizing heat conduction in a solid. The primary heat carriers are known to be electrons and phonons, quasiparticles corresponding to lattice vibrations. In current thermal engineering, efforts are underway to modulate thermal conductivity and interfacial thermal resistance by elucidating and controlling the transport properties of heat carriers. In particular, heat conduction modulation focusing on the transport and scattering of phonons has been actively studied over the past decades as “phonon engineering.”
Controlled colonization of the human gut with a genetically engineered microbial therapeutic
Great paper highlighting key challenges for genetically engineered bacterial therapies in the human gut. It is respectable that this paper was published in Science despite some “negative” results. Although the genetically engineered bacteria were all supposed to die after removal of porphyrin from the diet, they sometimes rebounded. Even with an improved porphyrin pathway which was supposed to resist mutational rebound, the bacteria still persisted in a mouse model, apparently by mysterious non-mutational means. Maybe the microbiomes of the mice somehow supplied porphyrin to the bacteria without the knowledge of the researchers. Furthermore, therapeutic application of the genetically engineered bacteria in humans only resulted in modest (and not statistically significant) decreases in urine oxalate. This was partly due to horizontal gene transfer which replaced the engineered oxalate degradation pathway and partly due to the general fitness burden of the engineered oxalate degradation pathway. As such, this paper revealed a lot of important obstacles which will need to be worked on for bacterial therapies to move forward in the future.
(https://www.science.org/doi/10.1126/science.adu8000)
Precision microbiome programming for therapeutic applications is limited by challenges in achieving reproducible colonic colonization. Previously, we created an exclusive niche that we used to engraft engineered bacteria into diverse microbiota in mice by using a porphyran prebiotic. Building on this approach, we have now engineered conditional attenuation into a porphyran-utilizing strain of Phocaeicola vulgatus by replacing native essential gene regulation with a porphyran-inducible promoter to allow reversible engraftment. Engineering a five-gene oxalate degradation pathway into the reversibly engrafting strain resulted in a therapeutic candidate that reduced hyperoxaluria, a cause of kidney stones, in preclinical models.
Magnetic control of lithium enables a safe, explosion-free ‘dream battery’
A new battery technology has been developed that delivers significantly higher energy storage—enough to alleviate EV range concerns—while lowering the risk of thermal runaway and explosion.
A research team at POSTECH has developed a next-generation hybrid anode that uses an external magnetic field to regulate lithium-ion transport, effectively suppressing dendrite growth in high-energy-density electrodes.
A POSTECH research team—led by Professor Won Bae Kim of the Department of Chemical Engineering and the Graduate School of Battery Engineering, together with Dr. Song Kyu Kang and integrated Ph.D. student Minho Kim—has introduced a “magneto-conversion” strategy that applies an external magnetic field to ferromagnetic manganese ferrite conversion-type anodes.
Space travel will radically change human psychology and spirituality
It may cause us to geneticly engineer ourselves to live in dangerous environments too.
Throughout human history, we have associated our spirituality, myths, and religions with the sky. Constellations are peppered with sky stories, from Orion to Warepil (the eagle constellation of aboriginal Australians). The Lakota Native Americans associated the Milky Way as a path for departed souls. Jesus ascended to the heavens. The primary god of ancient Egyptians was Ra, the god of the Sun. And the entire Universe was seen inside Krishna’s mouth.
Jason Batt, a science fiction author, mythologist, and futurist, has spent a lot of time thinking about stories like this, and how our relationship with the heavens will change when we become a space-faring race. “So what happens to humanity?” Batt, who is also a co-founder of Deep Space Predictive Research Group and a Creative Manager of 100 Year Starship, pondered while speaking to Big Think. “What is going to change in us? What is going to transform?”
Even though we often associate our space travel with feats of engineering and science, there is an undeniable connection with our myth as well. We see this in how we name our rockets destined for space: Gemini, Apollo, Artemis. Going to space is big, not just for our technology, but for our spirits.