Concordance was high between imputed and sequenced APOE genotypes. Moreover, the researchers replicated known GWAS associations with diet-related biomarkers.
The authors also noted several limitations to provide context for future research. These include that the study population was predominantly of European ancestry, which may limit the generalizability of findings, and that the specific participant criteria (e.g., overweight, family history of dementia) mean the resource is not representative of the general population. They also advise that potential batch effects from specimen type and study site should be accounted for in future analyses.
This genetic resource enables analyses of genetic contributions to variability in cognitive responses to the MIND diet, supporting integrative analysis with other data types to delineate underlying biological mechanisms. The data will be made available to other researchers via The National Institute on Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS).
Three nano-glass spheres cling to one another. They form a tower-like cluster, similar to when you pile three scoops of ice cream on top of one another—only much smaller. The diameter of the nano cluster is ten times smaller than that of a human hair.
With the help of an optical device and laser beams, researchers at ETH Zurich have succeeded in keeping such objects almost completely motionless in levitation. This is significant when it comes to the future development of quantum sensors, which, together with quantum computers, constitute the most promising applications of quantum research.
The team’s work appears in Nature Physics.
Cyclic peptides, with their unique structures and versatile biological activities, hold great potential for combating skin aging issues such as wrinkles, laxity, and pigmentation. However, traditional discovery methods relying on iterative synthesis and screening are labor-intensive and resource-intensive. Here, we present an integrated platform combining automated rapid cyclopeptide synthesis, virtual screening, and biological activity assessment, enabling the transformation of designed cyclic peptide sequences into chemical entities within minutes with high crude purity. Using ADCP docking with the ADFR suite, we identified a series of novel cyclic peptides targeting JAK1, Keap1, and TGF-β proteins.
Physicist and computer scientist Stephen Wolfram explores how simple rules can generate complex realities, offering a bold new vision of fundamental physics and the structure of the universe.
Stephen Wolfram is a British-American computer scientist, physicist, and businessman. He is known for his work in computer algebra and theoretical physics. In 2012, he was named a fellow of the American Mathematical Society. He is the founder and CEO of the software company Wolfram Research, where he works as chief designer of Mathematica and the Wolfram Alpha answer engine.
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A study published in Cell Reports Medicine reports a scalable, data-driven computational framework for designing combinatorial immunotherapies, offering hope for patients with poor responses to current immunotherapies.
Immunotherapy, particularly immune checkpoint blockade (ICB), has revolutionized cancer treatment. Widespread resistance to ICB is a major challenge in clinical practice.
To enhance treatment efficacy and overcome resistance, combining ICB therapy with chemotherapy or targeted therapy has become an important research direction. However, candidate combinations rely on empirical selection from existing drugs, and it is difficult to discover new candidates.
One of the most promising approaches to overcoming this challenge is topological quantum computing, which aims to protect quantum information by encoding it in the geometric properties of exotic particles called anyons. These particles, predicted to exist in certain two-dimensional materials, are expected to be far more resistant to noise and interference than conventional qubits.
“Among the leading candidates for building such a computer are Ising anyons, which are already being intensely investigated in condensed matter labs due to their potential realization in exotic systems like the fractional quantum Hall state and topological superconductors,” said Aaron Lauda, professor of mathematics, physics and astronomy at the USC Dornsife College of Letters, Arts and Sciences and the study’s senior author. “On their own, Ising anyons can’t perform all the operations needed for a general-purpose quantum computer. The computations they support rely on ‘braiding,’ physically moving anyons around one another to carry out quantum logic. For Ising anyons, this braiding only enables a limited set of operations known as Clifford gates, which fall short of the full power required for universal quantum computing.”
But in a new study published in Nature Communications, a team of mathematicians and physicists led by USC researchers has demonstrated a surprising workaround. By adding a single new type of anyon, which was previously discarded in traditional approaches to topological quantum computation, the team shows that Ising anyons can be made universal, capable of performing any quantum computation through braiding alone. The team dubbed these rescued particles “neglectons,” a name that reflects both their overlooked status and their newfound importance. This new anyon emerges naturally from a broader mathematical framework and provides exactly the missing ingredient needed to complete the computational toolkit.
Researchers from MIT and elsewhere have designed a novel transmitter chip that significantly improves the energy efficiency of wireless communications, which could boost the range and battery life of a connected device.
Their approach employs a unique modulation scheme to encode digital data into a wireless signal, which reduces the amount of error in the transmission and leads to more reliable communications.
A joint research team from Japan has observed “heavy fermions,” electrons with dramatically enhanced mass, exhibiting quantum entanglement governed by the Planckian time—the fundamental unit of time in quantum mechanics. This discovery opens up exciting possibilities for harnessing this phenomenon in solid-state materials to develop a new type of quantum computer. The findings are published in npj Quantum Materials.
Heavy fermions arise when conduction electrons in a solid interact strongly with localized magnetic electrons, effectively increasing their mass. This phenomenon leads to unusual properties like unconventional superconductivity and is a central theme in condensed matter physics. Cerium-rhodium-tin (CeRhSn), the material studied in this research, belongs to a class of heavy fermion systems with a quasi-kagome lattice structure, known for its geometrical frustration effects.
Researchers investigated the electronic state of CeRhSn, known for exhibiting non-Fermi liquid behavior at relatively high temperatures. Precise measurements of CeRhSn’s reflectance spectra revealed non-Fermi liquid behavior persisting up to near room temperature, with heavy electron lifetimes approaching the Planckian limit. The observed spectral behavior, describable by a single function, strongly indicates that heavy electrons in CeRhSn are quantum entangled.
AMD just reported its Q2 2025 earnings, and it’s attributing a new quarterly revenue record of $7.7 billion to one particular thing: “record server and PC processor sales.” And while AMD doesn’t mention its flagging competitor Intel, it seems many are turning to Team Red: AMD just crossed 40 percent market share for the first time on the Steam Hardware Survey of PC gamers, and it may have 40 percent server market share soon too.