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Scientists at the Indian Institute of Science (IISc) have developed a new approach to potentially detect and kill cancer cells, especially those that form a solid tumor mass. They have created hybrid nanoparticles made of gold and copper sulfide that can kill cancer cells using heat and enable their detection using sound waves, according to a study published in ACS Applied Nano Materials.

Early detection and treatment are key in the battle against cancer. Copper sulfide nanoparticles have previously received attention for their application in cancer diagnosis, while gold nanoparticles, which can be chemically modified to target cancer cells, have shown anticancer effects. In the current study, the IISc team decided to combine these two into hybrid nanoparticles.

“These particles have photothermal, oxidative stress, and photoacoustic properties,” says Jaya Prakash, Assistant Professor at the Department of Instrumentation and Applied Physics (IAP), IISc, and one of the corresponding authors of the paper. Ph.D. students Madhavi Tripathi and Swathi Padmanabhan are co-first authors.

Archaeological secrets from thousands of years ago in northeast Africa have been unearthed thanks to modern-day scientific innovations. A process known as chemical imaging recently revealed “hidden mysteries” about ancient Egyptian paintings located in tomb chapels close to the Nile River — and portable devices made it possible to analyze the 3,000-year-old art on-site in its original locations.

As announced in the peer-reviewed publication PLOS One on July 12, the portable devices enabled Philippe Martinez of France’s Sorbonne University, along with a team of international colleagues, to visit the tombs and analyze the paintings dating back to the Ramesside Period, which lasted from approximately 1,295 B.C. to 1,070 B.C. They were located in tomb chapels in the Theban Necropolis, located just west of the Nile, per a press release.

Thanks to the chemical imaging technology, the team gathered detailed information on the paintings, including paint composition and layering, and alterations that had been made to the pictures over time.

An international research team headed by Johannes Karges, PhD, of the faculty of chemistry and biochemistry at Ruhr University Bochum, Germany, has developed nanoparticles that accumulate in cancer cells and eliminate them after being photoactivated. The research team also labeled them in such a way that immune cells learn to eliminate similar cells throughout the body which could even mean undetected metastases can be treated.

The researchers presented their findings in the journal Nature Communications in an article titled, “Theranostic imaging and multimodal photodynamic therapy and immunotherapy using the mTOR signaling pathway.”

“Tumor metastases are considered the leading cause of cancer-associated deaths,” the researchers wrote. “While clinically applied drugs have demonstrated to efficiently remove the primary tumor, metastases remain poorly accessible. To overcome this limitation, herein, the development of a theranostic nanomaterial by incorporating a chromophore for imaging and a photosensitizer for treatment of metastatic tumor sites is presented. The mechanism of action reveals that the nanoparticles are able to intervene by local generation of cellular damage through photodynamic therapy as well as by systemic induction of an immune response by immunotherapy upon inhibition of the mTOR signaling pathway which is of crucial importance for tumor onset, progression, and metastatic spreading.”

In an effort to create robots capable of controlling their own life-cycles, researchers have developed squishy little devices that can melt themselves into a puddle of goo.

“We have mimicked death in a life cycle where the robot could end itself,” Seoul National University engineer Min-Ha Oh told Peter Grad at Tech Xplore.

This ‘death’ is triggered by internal ultraviolet LEDs that destabilize the chemical composition of the robot. This process takes about an hour though, so it’s likely we have a few decades before we’ll see robots being employed as the kinds of vanishing spies proposed by the researchers.

Concrete is responsible for 8 percent of the world’s carbon emissions.

In construction, concrete emissions refer to the greenhouse gas emissions associated with the production and use of concrete, one of the most widely used construction materials globally. Due to energy-intensive cement production processes and chemical reactions that take place during concrete curing, the concrete industry is a substantial source of carbon dioxide (CO₂) emissions, responsible for an estimated 8 percent of the world’s emissions.

Cement, which is a byproduct of heating limestone (calcium carbonate) and other minerals to high temperatures in a kiln, is the main component of concrete. In order to produce the… More.

Continue reading “MIT student uses AI to design buildings with less concrete” »

Smirkdingo/iStock.

Their research, recently published in the journal Nature, introduces a photocatalytic method that leverages light energy to activate water, potentially opening up new avenues in chemistry, particularly in the synthesis of compounds from simpler materials.

Osteoarthritis (OA) is a prevalent global health concern, posing a significant and increasing public health challenge worldwide. Recently, biomaterials have emerged as a highly promising strategy for OA therapy due to their exceptional physicochemical properties and capacity to regulate pathological processes. However, there is an urgent need for a deeper understanding of the potential therapeutic applications of these biomaterials in the clinical management of diseases, particularly in the treatment of OA. In this comprehensive review, we present an extensive discussion of the current status and future prospects concerning biomaterials for OA… More.

Herein, in this review, we summarize the advanced strategies developed for enhancing OA therapy based on the biomaterials. We conducted a comprehensive literature search using relevant databases such as PubMed, Scopus, and Web of Science. The search was focused on peer-reviewed articles and research papers published within the last ten years (from 2013 to 2023). We utilized specific keywords related to biomaterials”, biomaterials” and “osteoarthritis therapy” to retrieve relevant studies. First, we provide an overview of the pathophysiology of OA and the limitations of current treatment options. Second, we explore the various types of biomaterials which have been used for OA therapy, including nanoparticles, nanofibers, and nanocomposites. Third, we highlight the advantages and challenges associated with the use of biomaterials in OA therapy, such as toxicity, biodegradation, and regulatory issues. Finally, advanced biomaterials-based OA therapies with their potential for clinical translation and emerging biomaterials directions for OA therapy are discussed.

Characteristics of Biomaterials

Nanotechnology-boosted biomaterials have attracted considerable attention in recent years as promising candidates for revolutionizing the field of therapeutics.^12,13 These materials combine the unique properties of nanotechnology with the versatility and biocompatibility of biomaterials, offering numerous advantages over existing therapeutic approaches. Nanotechnology enables the precise engineering of biomaterials at the nanoscale, allowing for the encapsulation and controlled release of therapeutic agents, such as drugs and growth factors.^14–17 This feature facilitates targeted and sustained drug delivery to specific sites within the body, reducing systemic side effects and enhancing treatment efficacy. In the context of OA, this targeted drug delivery can be utilized to deliver anti-inflammatory agents or disease-modifying drugs directly to affected joint tissues, promoting tissue repair and alleviating symptoms. Furthermore, biomaterials can be designed to mimic the native tissue environment, thereby enhancing their biocompatibility and reducing the risk of adverse reactions or immune responses.¹⁸ This characteristic is crucial for successful integration and long-term functionality of biomaterials in biomedical applications. Moreover, nanomaterials can facilitate tissue regeneration by stimulating cellular responses and promoting tissue growth.¹⁹ In the context of OA, biomaterials can assist in cartilage repair and regeneration, potentially slowing down disease progression and improving joint function.³ In addition, nanotechnology allows for the customization of biomaterials with a wide range of physical, chemical, and biological properties.¹³ This flexibility enables the development of multifunctional biomaterials that can simultaneously perform multiple tasks, such as drug delivery, imaging, and tissue regeneration. These advantages collectively contribute to their potential as innovative solutions in addressing various biomedical challenges and improving patient outcomes. In this section, we will discuss some of the key properties of biomaterials and their impact on OA treatment.

Continue reading “Nanotechnology-Boosted Biomaterials for Osteoarthritis” »

Hydrogen is often touted as a future energy solution, especially when generated through environmentally friendly methods. Beyond its energy potential, hydrogen plays a crucial role in producing active ingredients and various essential compounds. To generate hydrogen, water (H₂O) can be transformed into hydrogen gas (H2) through a sequence of chemical reactions.

However, as water molecules are very stable, splitting them into hydrogen and oxygen presents a big challenge to chemists. For it to succeed at all, the water first has to be activated using a catalyst – then it reacts more easily.

A team of researchers led by Prof. Armido Studer at the Institute of Organic Chemistry at Münster University (Germany) has developed a photocatalytic process in which water, under mild reaction conditions, is activated through triaryl phosphines and not, as in most other processes, through transition metal complexes.

To understand why this is a big deal, for a long time its been understood that (to vastly oversimplify things) the brain is primarily composed to two kinds of cells: glial cells, which are basically the brain’s infrastructure; and neurons, which communicate with each other with chemicals called neurotransmitters at special sites called synapses.

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Add another layer of complexity to our understanding of the brain. Researchers at University of Lausanne have discovered that a heretofore unknown class of cell is also involved in the complicated internal communications of the brain. The research was published Wednesday in Nature.

Continue reading “InnovationRx: New Insight Into How The Brain Works” »