Lifeboat Foundation

An international research team has taken a decisive step toward a new generation of atomic clocks. At the European XFEL X-ray laser, the researchers have created a much more precise pulse generator based on the element scandium, which enables an accuracy of one second in 300 billion years—that is about a thousand times more precise than the current standard atomic clock based on cesium. The team presents its success in the journal Nature.

Atomic clocks are currently the world’s most accurate timekeepers. These clocks have used electrons in the atomic shell of chemical elements, such as cesium, as a pulse generator in order to define the time. These electrons can be raised to a higher energy level with microwaves of a known frequency. In the process, they absorb the microwave radiation.

An atomic clock shines microwaves at cesium atoms and regulates the frequency of the radiation such that the absorption of the microwaves is maximized; experts call this a resonance. The quartz oscillator that generates the microwaves can be kept so stable with the help of resonance that cesium clocks will be accurate to within one second within 300 million years.

Researchers have identified two ion channel switches that regulate the release of dopamine in the brain, a first step that might one day lead to therapeutics for a wide range of diseases and disorders that currently have few solutions.

The switches help regulate learning and motivational state in mice. Humans also have hundreds of these channels, which govern many chemical and hormonal processes that influence behavior and mood. The University of Washington School of Medicine research team hopes to identify drugs to target these channels. Those drug candidates could then be tested in clinical trials.

“The ability to precisely manipulate how dopamine-producing neurons of the brain regulate different behaviors is a major step toward developing better therapies for a range of mental illnesses,” said Larry Zweifel, professor of psychiatry & behavioral sciences at the UW School of Medicine.

Most of today’s EVs use lithium-ion batteries, the same kind you’ll find in your smartphone or laptop. These batteries all have two electrodes (one positive and one negative), and the negative one is usually made of graphite.

While the battery is being charged, the lithium ions flow from the side of the battery with the positive electrode to the side with the negative electrode. If the charging happens too fast, the flow can be disrupted, causing the battery to short circuit.

StoreDot’s EV battery replaces the graphite electrode with one made from nanoparticles based on the chemical element germanium — this allows the ions to flow more smoothly and quickly, enabling a faster charge.

An extremely important landmark paper by Watson et al. from David Baker’s group. They developed RFdiffusion, a generative AI for protein engineering. With this tool, scientists can generate new protein designs. The software can generate novel monomers, multimers, and symmetric protein cages. It can generate proteins that bind to desired targets as well as enzymes that position active sites at a desired location on the structure. I would say that this technology has the potential to dramatically alter how biology and biotechnology is done. I’ve been waiting for something like this since middle school! So exciting to see protein engineering reaching this point!! #computationalbiology #proteinengineering #syntheticbiology #biotechnology #biochemistry #ai #generativeai

Fine-tuning the RoseTTAFold structure prediction network on protein structure denoising tasks yields a generative model for protein design that achieves outstanding performance on a wide range of protein structure and function design challenges.

The Giant Magellan Telescope begins the four-year process to fabricate and polish its seventh and final primary mirror, the last required to complete the telescope’s 368 square meter light collecting surface, the world’s largest and most challenging optics ever produced. Together, the mirrors will collect more light than any other telescope in existence, allowing humanity to unlock the secrets of the universe by providing detailed chemical analyses of celestial objects and their origin.

Last week, the University of Arizona Richard F. Caris Mirror Lab closed the lid on nearly 20 tons of the purest optical glass inside a one-of-a-kind oven housed beneath the stands of the Arizona Wildcats Football Stadium. The spinning oven will heat the glass to 1,165°C so as it melts, it is forced outward to form the mirror’s curved paraboloid surface. Measuring 8.4-meters in diameter—about two stories tall when standing on edge—the mirror will cool over the next three months before moving into the polishing stage.

At 50 million times more powerful than the human eye, “the telescope will make history through its future discoveries,” shares Buell Jannuzi, Principal Investigator for the fabrication of the Giant Magellan Telescope primary mirror segments, Director of Steward Observatory, and Head of the Department of Astronomy at the University of Arizona. “We are thrilled to be closing in on another milestone in the fabrication of the Giant Magellan Telescope.”

Self-sustaining chemical reactions that could support biology radically different from life as we know it might exist on many different planets using a variety of elements beyond the carbon upon which Earth’s life is based, a new study finds.

On Earth, life is based on organic compounds. These molecules are composed of carbon and often include other elements such as hydrogen, oxygen, nitrogen, phosphorus and sulfur.

In a recent study published in Science Advances, researchers from the California Institute of Technology, led by Dr. Wei Gao, have developed a machine learning (ML)–powered 3D-printed epifluidic electronic skin for multimodal health surveillance. This wearable platform enables real-time physical and chemical monitoring of health status.

Wearable health devices have the potential to revolutionize the medical world, offering real-time tracking, personalized treatments, and early diagnosis of diseases.

However, one of the main challenges with these devices is that they don’t track data at the molecular level, and their fabrication is challenging. Dr. Gao explained why this served as a motivation for their team.

A genetically engineered marine microorganism is shown to break down polyethylene terephthalate (PET) in saltwater. This plastic, used in everything from water bottles to clothing, is a significant contributor to microplastic pollution in oceans.

“This is exciting because we need to address plastic pollution in marine environments,” says Nathan Crook, corresponding author of a paper on the work and an assistant professor of chemical and biomolecular engineering at North Carolina State University.

In a new study, self-sustaining chemical reactions were discovered which carry the potential to support alien life, which is very different from the elements present on Earth.

The biology of Earth hinges on organic compounds which comprise carbon along with elements like phosphorus, sulphur, nitrogen, oxygen and hydrogen. Scientists believe that alternative chemical frameworks can lead to the existence of alien life forms.

For long, scientists have wondered if alien life might evolve on the basis of significantly different chemistry. Researchers have speculated if silicon may work as a backbone for biology.