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Category: chemistry – Page 109

This is a bit technical. “nucleocytoplasmic compartmentalization assay”, Yeah buddy.

Life is dependent on the preservation and storage of information. The genome and epigenome are the two central storehouses of information in eukaryotes, and although they work interdependently, they are fundamentally quite different. Genetic information is consistent across all body cells throughout the life of an individual while epigenetic information varies between cells as well as changes over time and as per environment.

Researchers have identified several hallmarks of aging such as epigenetic alterations, genomic instability, cellular senescence, telomere attrition, mitochondrial dysfunction, and others [1]. These are known to play a role in the dysfunction and deterioration of cells with age. David Sinclair and other researchers have previously indicated that loss of epigenetic information can cause changes in gene expression, leading to cellular identity loss. Previous studies in mice have also shown that cell injuries such as cell crushing and DNA double-strand breaks can promote loss of epigenetic information which can accelerate aging along with age-related diseases [2].

Cellular senescence is a state of stable cell cycle arrest that can be triggered due to a wide range of extrinsic as well as intrinsic factors. It promotes tissue remodeling, wound repair, and cancer prevention by stopping the proliferation of damaged and aged cells. Senescent cells are characterized by metabolic and morphological alterations, reorganization of the chromatin, and release of pro-inflammatory substances known as the senescence-associated secretory phenotype (SASP) [3]. Irreparable DNA damage, loss of epigenetic information, and telomere shortening are a few factors that can initiate cellular senescence. Accumulation of senescent cells with age results in inflammation as well as the generation of reactive oxygen species (ROS).

Continue reading “Is the reversal of cellular aging possible through chemical means?” | >

A new model demonstrates that chasing interactions can induce dynamical patterns in the organization of bacterial species. Structural patterns can be created due to the chasing interactions between two bacterial species.

In the new model, scientists from the Max Planck Institute for Dynamics and Self-Organization (MPI-DS) describe how on the individual level can result in a global of . Their findings provide insights into general mechanisms of collective behavior. The findings are published in the journal Physical Review Letters.

In a recent study, scientists from the department Living Matter Physics at MPI-DS developed a model describing communication pathways in . Bacteria show an overall organizational pattern by sensing the concentration of chemicals in their environment and adapting their motion.

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The number of kids being diagnosed with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) has risen sharply in recent decades, and a new study points to the common plastic additive bisphenol A (BPA) as a potential reason why.

BPA is used in a lot of plastics and plastic production processes, and can also be found inside food and drink cans. However, previous research has also linked it to health issues involving hormone disruption, including breast cancer and infertility.

In this new study, researchers from Rowan University and Rutgers University in the US looked at three groups of children: 66 with autism, 46 with ADHD, and 37 neurotypical kids. In particular, they analyzed the process of glucuronidation, a chemical process the body uses to clear out toxins within the blood through urine.

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Scientists have caught fast-moving hydrogen atoms—the keys to countless biological and chemical reactions—in action.

A team led by researchers at the Department of Energy’s SLAC National Accelerator Laboratory and Stanford University used ultrafast electron diffraction (UED) to record the motion of hydrogen atoms within ammonia molecules. Others had theorized they could track hydrogen atoms with electron diffraction, but until now nobody had done the experiment successfully.

The results, published in Physical Review Letters, leverage the strengths of high-energy Megaelectronvolt (MeV) electrons for studying hydrogen atoms and proton transfers, in which the singular proton that makes up the nucleus of a hydrogen atom moves from one molecule to another.

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For more information on addiction services at #YaleMedicine, visit: https://www.yalemedicine.org/departments/program-in-addiction-medicine.

Written and produced by Yale Neuroscience PhD student Clara Liao.

Addiction is now understood to be a brain disease. Whether it’s alcohol, prescription pain pills, nicotine, gambling, or something else, overcoming an addiction isn’t as simple as just stopping or exercising greater control over impulses. That’s because addiction develops when the pleasure circuits in the brain get overwhelmed, in a way that can become chronic and sometimes even permanent. This is what’s at play when you hear about reward “systems” or “pathways” and the role of dopamine when it comes to addiction. But what does any of that really mean? One of the most primitive parts of the brain, the reward system, developed as a way to reinforce behaviors we need to survive—such as eating. When we eat foods, the reward pathways activate a chemical called dopamine, which, in turn, releases a jolt of satisfaction. This encourages you to eat again in the future. When a person develops an addiction to a substance, it’s because the brain has started to change. This happens because addictive substances trigger an outsized response when they reach the brain. Instead of a simple, pleasurable surge of dopamine, many drugs of abuse—such as opioids, cocaine, or nicotine—cause dopamine to flood the reward pathway, 10 times more than a natural reward. The brain remembers this surge and associates it with the addictive substance. However, with chronic use of the substance, over time the brain’s circuits adapt and become less sensitive to dopamine. Achieving that pleasurable sensation becomes increasingly important, but at the same time, you build tolerance and need more and more of that substance to generate the level of high you crave. Addiction can also cause problems with focus, memory, and learning, not to mention decision-making and judgement. Seeking drugs, therefore, is driven by habit—and not conscious, rational decisions. Unfortunately, the belief that people with addictions are simply making bad choices pervades. Furthermore, the use of stigmatizing language, such as “junkie” and “addict” and getting “clean,” often creates barriers when it comes to accessing treatment. There’s also stigma that surrounds treatment methods, creating additional challenges. Though treatment modalities differ based on an individual’s history and the particular addiction he or she has developed, medications can make all the difference. “A lot of people think that the goal of treatment for opioid use disorder, for example, is not taking any medication at all,” says David A. Fiellin, MD, a Yale Medicine primary care and addiction medicine specialist. “Research shows that medication-based treatments are the most effective treatment. Opioid use disorder is a medical condition just like depression, diabetes or hypertension, and as with those conditions, it is most effectively treated with a combination of medication and counseling.”

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Missions to the Moon, missions to Mars, robotic explorers to the outer Solar System, a mission to the nearest star, and maybe even a spacecraft to catch up to interstellar objects passing through our system. If you think this sounds like a description of the coming age of space exploration, then you’d be correct! At this moment, there are multiple plans and proposals for missions that will send astronauts and/or probes to all of these destinations to conduct some of the most lucrative scientific research ever performed. Naturally, these mission profiles raise all kinds of challenges, not the least of which is propulsion.

Simply put, humanity is reaching the limits of what conventional (chemical) propulsion can do. To send missions to Mars and other deep space destinations, advanced propulsion technologies are required that offer high acceleration (delta-v), specific impulse (Isp), and fuel efficiency. In a recent paper, Leiden Professor Florian Neukart proposes how future missions could rely on a novel propulsion concept known as the Magnetic Fusion Plasma Drive (MFPD). This device combines aspects of different propulsion methods to create a system that offers high energy density and fuel efficiency significantly greater than conventional methods.

Florian Neukart is an Assistant Professor with the Leiden Institute of Advanced Computer Science (LIACS) at Leiden University and a Board Member of the Swiss quantum technology developer Terra Quantum AG. The preprint of his paper recently appeared online and is being reviewed for publication in Elsevier. According to Neukart, technologies that can surmount conventional chemical propulsion (CCP) are paramount in the present era of space exploration. In particular, these technologies must offer greater energy efficiency, thrust, and capability for long-duration missions.

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The Nobel Physics Prize was awarded on Tuesday to three scientists for their work on attoseconds, which are almost unimaginably short periods of time.

Their work using lasers gives scientists a tool to observe and possibly even manipulate electrons, which could spur breakthroughs in fields such as electronics and chemistry, experts told AFP.

Attoseconds are a billionth of a billionth of a second.

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Physicists have performed the first quantum calculations to be carried out using individual atoms sitting on a surface.

The technique, described on 5 October in Science1, controls titanium atoms by beaming microwave signals from the tip of a scanning tunnelling microscope (STM). It is unlikely to compete any time soon with the leading approaches to quantum computing, including those adopted by Google and IBM, as well as by many start-up companies. But the tactic could be used to study quantum properties in a variety of other chemical elements or even molecules, say the researchers who developed it.

At some level, everything in nature is quantum and can, in principle, perform quantum computations. The hard part is to isolate quantum states called qubits — the quantum equivalent of the memory bits in a classical computer — from environmental disturbances, and to control them finely enough for such calculations to be achieved.

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My idea is that all the waste from human waste has vital things in it we could even someday have everything recycled back into its original form like if waste medicines or other nutrients could be extracted we could essentially recycle human waste having a near unlimited supply of chemicals which would be great for space traveling where nothing is wasted.

Poop’s got an image problem

And there’s also the issue of acceptance. Research suggests there are both cultural and psychological barriers standing in the way of wider bodily waste recycling.

In Ghana, for example, fecophobia — a fear of solid human waste, particularly in its untreated human form — is commonplace, and many perceive growing food with it as unhygienic. Though one study suggested once people understand that feces-based fertilizer is treated and processed, the negative perception is significantly lower.

Continue reading “Recycling our poop to grow food more sustainably” | >