Lifeboat Foundation

Researchers headed by a team at Mass Eye and Ear, Harvard Medical School, reported positive data from a Phase I clinical study evaluating a stem cell treatment known as cultivated autologous limbal epithelial cell transplantation (CALEC), in patients with significant chemical burns in one eye. Results from the study, reported in Science Advances, showed treatment to be safe and well tolerated in four patients who were followed for 12 months. The CALEC recipients experienced restored cornea surfaces, with two trial participants able to undergo subsequent corneal transplant, and two reporting significant improvements in vision without additional treatment.

The Phase I study was designed to determine preliminary safety and feasibility before advancing to a second phase of the trial, and the researchers consider the newly reported early findings to be promising. On the basis of these initial results the team started recruiting for a second phase of the trial that will investigate longer-term safety and efficacy in greater numbers of patients.

“Our early results suggest that CALEC might offer hope to patients who had been left with untreatable vision loss and pain associated with major cornea injuries,” said principal investigator Ula Jurkunas, MD, associate director of the Cornea Service at Mass Eye and Ear and an associate professor of ophthalmology at Harvard Medical School. “Cornea specialists have been hindered by a lack of treatment options with a high safety profile to help our patients with chemical burns and injuries that render them unable to get an artificial cornea transplant. We are hopeful with further study, CALEC can one day fill this crucially needed treatment gap.”

Now maybe we can snack happily! I think this applies to regular food too? I can eat all the Chinese and Mexican and Italian food I want? Plus for people with genetic risks can’t this not help? I hope so.

Mice fed a high-sugar, high-fat diet for most of their lives managed to escape weight gain and protect their livers when they were treated with an experimental new drug.

The small-molecule drug was developed by a team led by The University of Texas Health Science Center at San Antonio (UT Health San Antonio). K nown by its chemical acronym CPACC, it works by limiting the entry of magnesium into the mitochondria, the parts of the cell in charge of generating energy and burning calories.

Continue reading “Scientists Develop Drug That Prevents Weight Gain in Junk-Food-Eating Mice” »

This could lead to cures of all diseases and disorders of the human biological systems because one could edit them out 😗😁.

A molecular machine that can be programmed to position a substrate at one of two directing sites on a molecule, which control the stereochemistry of addition to the substrate, demonstrates complexity, precision and function previously only observed in nature.

Creating novel materials by combining layers with unique, beneficial properties seems like a fairly intuitive process—stack up the materials and stack up the benefits. This isn’t always the case, however. Not every material will allow energy to travel through it the same way, making the benefits of one material come at the cost of another.

Using cutting-edge tools, scientists at the Center for Functional Nanomaterials (CFN), a U.S. Department of Energy (DOE) User Facility at Brookhaven National Laboratory, and the Institute of Experimental Physics at the University of Warsaw have created a new layered structure with 2D materials that exhibits a unique transfer of energy and charge. Understanding its material properties may lead to advancements in technologies such as solar cells and other optoelectronic devices. The results were published in the journal Nano Letters.

Transition metal dichalcogenides (TMDs) are a class of materials structured like sandwiches with atomically thin layers. The meat of a TMD is a transition metal, which can form chemical bonds with electrons on their outermost orbit or shell, like most elements, as well as the next shell. That metal is sandwiched between two layers of chalcogens, a category of elements that contains oxygen, sulfur, and selenium.

Researchers have developed a novel material using tiny organic crystals that convert light into a substantial mechanical force able to lift 10,000 times its own mass. Without the need for heat or electricity, the photomechanical material could one day drive wireless, remote-controlled systems that power robots and vehicles.

Photomechanical materials are designed to transform light directly into mechanical force. They result from a complex interplay between photochemistry, polymer chemistry, physics, mechanics, optics, and engineering. Photomechanical actuators, the part of a machine that helps achieve physical movements, are gaining popularity because external control can be achieved simply by manipulating light conditions.

Researchers from the University of Colorado, Boulder, have taken the next step in the development of photomechanical materials, creating a tiny organic crystal array that bends and lifts objects much heavier than itself.

A new discovery by the Polytechnic University of Milan opens up new perspectives in the field of sustainable chemical synthesis, promoting innovative solutions that allow chemicals to be created in a more efficient and environmentally friendly way. The findings were recently published in the journal Nature Synthesis.

Using the innovative technique of dispersing isolated atoms on carbon nitride supports, the team developed a catalyst that is more active and selective in esterification reactions. This is an important reaction in which carboxylic acids and bromides are combined to form products used in the manufacture of medicines, food additives, and polymers.

The revolutionary feature of this new catalyst is that it reduces the use of rare metals, a significant step towards conserving critical resources and making processes more sustainable. In addition, the catalyst can be activated by sunlight, eliminating the need for energy-intensive methods. This discovery holds enormous potential in reducing dependence on finite resources and lowering the environmental impact of catalytic processes.

How molecules change when they react to stimuli such as light is fundamental in biology, for example during photosynthesis. Scientists have been working to unravel the workings of these changes in several fields, and by combining two of these, researchers have paved the way for a new era in understanding the reactions of protein molecules fundamental for life.

The large international research team, led by Professor Jasper van Thor from the Department of Life Sciences at Imperial, report their results in the journal Nature Chemistry.

Crystallography is a powerful technique in structural biology for taking ‘snapshots’ of how molecules are arranged. Over several large-scale experiments and years of theory work, the team behind the new study integrated this with another technique that maps vibrations in the electronic and nuclear configuration of molecules, called spectroscopy.

While the current Oppenheimer blockbuster film focused on the destructive power of nuclear weapons, more peaceful uses of atomic propulsion for space exploration are now gaining once again momentum. ROB COPPINGER reports.

Nuclear fission and fusion power propulsion are under investigation in Europe and the US with an in-space engine demonstration planned by 2027 — with the news last month that Lockheed Martin had been selected to develop a nuclear thermal propulsion system for DARPA’s DRACO programme (see below).

Continue reading “Atomic rockets are back” »

Dr Kathryn Mumford is an Associate Professor in the Department of Chemical Engineering at the University of Melbourne, specialising in separation processes in ion exchange, solvent absorption and solvent extraction technologies. In collaboration with industry, her recent research has pioneered a more efficient, greener process to produce lithium carbonate.

Dr Mumford leads the Sustainable Resources platform, which focuses on research to support the transition to green energy, reduce environmental impact and develop smart mining and processing. Here, she discusses how the platform is tackling the industry’s greatest challenges, and the role the sector will play in decarbonising the world.

I’ve been thinking about sustainability and environmental health throughout my whole career. I saw the consequence of waste and was compelled to develop ways to reduce its impact. My PhD was around environmental clean-up, specifically cleaning up tip sites and fuel spills at contaminated sites in Antarctica – I’ve since been back to Antarctica seven times on clean-up missions.